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Skip Navigation LinksJRI > Archive > April-June 2003, Volume 4, Issue 2 > Induction of ovulation with a single dose of metrodin in PCOS patients resistant to clomiphene citrate



Volume 4, Issue 2, Number 14 / April-June
(pages 115-122)


Induction of ovulation with a single dose of metrodin in PCOS patients resistant to clomiphene citrate




 Corresponding Author
Infertility Treatment Ward, Shariati Hospital, Faculty of Medicine, Tehran University of Medical Sciences & Health Services University, Tehran, Iran

Infertility Treatment Ward, Shariati Hospital, Faculty of Medicine, Tehran University of Medical Sciences & Health Services University, Tehran, Iran

Department of Obstet . and Gynecol ,Shariati Hospital, Tehran Medical Sciences University, Tehran, Iran

Department of Obstet . and Gynecol ,Shariati Hospital, Tehran Medical Sciences University, Tehran, Iran


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Abstract
Polycystic Ovary Syndrome (PCOS) is a common cause of chronic anovulation and is frequently associated with different clinical symptoms. The main objective of this clinical trial was to evaluate the therapeutic effects of single dose of metrodin administration to induce follicular response in PCOS patients at Shariati hospital (2001-2002). PCOS was the main cause of the infertility in selected patients. All the patients were treated with maximal dose of clomiphene citrate (150mg/d) from the 3rd to the 7th days of their menstrual cycle while controlling with vaginal sonography for the follicular response. Sixty patients with follicular response were selected and studied we combined the previous strategy of clomiphene citrate administration with muscular injection of single dose (75 IU) of metrodin at the 3th day of cycle. The positive follicular response was the appearance of dominant follicle with 18 mm diameters in the 14th to 16th days. In the presence of positive follicular response, 10000 IU of HCG was injected at the same day. Intercourse was allowed that night and the 2 subsequent days. Progesterone level was measured in the 21th day of the cycle, with levels equal or above the 3 ng/ml suggesting “ovulation”. β-HCG level was measured in the 32th and 34th days of the cycle, If the menstruation was delayed. The levels equal or more than 200IU/l or significant increase in β-HCG level suggested chemical pregnancy. To confirm a normal intrauterine pregnancy, vaginal sonography was performed in the 7th week; in which, visualization of the gestational sac, fetal pole, and monitoring of fetal heart rate were suggestive. Among total sixty patients, 31 (%51.7) had positive follicular response, 30 (%50) had ovulation and 15 had positive pregnancy tests. One patient had spontaneous abortion after positive pregnancy test and before sonography. Two patients had spontaneous abortion after positive sonography and two patients had preterm labor. Nine patients had term pregnancy. Complications were observed in four patients. The achieved data were analyzed, by fisher and x2 tests. Although there was no significant correlation between follicular response and variants such as age, BMI, infertility type or menstrual state, there was a statistically high correlation between pregnancy rate and progesterone level at 21th day of cycle (p<0.0001). The result of this study suggests that using a single dose metrodin administration, has a significant influence on follicular response, induction of ovulation and creating pregnancy.

Keywords: Metroding, Follicular response, Clomiphene citrate, Infertility, Polycystic ovary syndrome


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References
  1. Speroff leon; Glass Robert H., Kase Nathan G. Clinical Gynecologic Endocrinology and Infertility.Lippincot Williams & Wilkins, 6th Edition 1999;(12):492-7,(15):577,(30):1102-5.
  2. Ernest N.H., Flora T.O., William S.W., Ho P.C. A prospective, open randomized clinical study to assess the efficacy and safety of two gonadotropin preparations adminstered in who group II anovulatory subfertile women. Obs Gyn Res. 1988;24(5):355-61.
  3. Ghosh S., Goswami S., Chakravarty B.N. Induction of ovulation with a single dose of Metrodine - HP in PCOS. 56th Annual Meeting of the American Society for Reproduction Medicine. Fertil Steril 2000;74(3):33.
  4. Chen W., Zhang Y., Dai Q. Chronic low dose follicle stimulation hormone step up regimen in the treatment of polycystic ovary syndrom related anovulatory infertility with clomiphene resistance. ZhonghauFu Chan Ke Za Zhi. 2000;35(10):588-90.
  5. Raj S.G., Berger M.J., Grimes E.M., Taymor ML. The use of gonadotropins for the induction of ovulation in women with polycystic ovarian disease. Fertil Steril. 1977;28(12):1280-4.
  6. Hughes E., Collins J., Vandekerchckhove P. Ovulation induction with urinary follicle stimulating hormone versus human menopausal gonadotropin for clomiphene resistant polycystic ovary syndrom. Syst Rev 2000; 2:CD000087:1.
  7. Nugent, D., Vandekerckhove P., Hughes E., Arnot M., Lifford R. Gonadotropin therapy for ovulation induction in subfertility associated with polycystic ovary syndrom. Cochrane Database Sys Rev 2000;4:CD 0001410:1-2.
  8. Homburg R., Howles CM. Low dose FSH therapy for anovulatory infertility associated with polysystic ovary syndrom: rational, results, reflections and refinements. Hum Reprod Update. 1999;5(5):493-9.



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