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Skip Navigation LinksJRI > Archive > October-December 2004, Volume 5, Issue 4 > Effect of Dexamethasone on ovarian response in infertile women aged over 35 years undergoing IVF/ICSI program



Volume 5, Issue 4, Number 20 / October-December
(pages 308-314)


Effect of Dexamethasone on ovarian response in infertile women aged over 35 years undergoing IVF/ICSI program




 Corresponding Author
1- Department of Endocrinology and Female Infertility, Royan Institute, Tehran, Iran
2- Department of Obstetrics and Gynecology, Shahid Akbarabadi Hospital, Faculty of Medicine, Iran university of Medical Sciences, Tehran, Iran

1- Department of Endocrinology and Female Infertility, Royan Institute, Tehran, Iran
2- Royan Research Center, Endocrinology & Infertility Department, Tehran, Iran

Royan Research Center, Endocrinology & Infertility Department, Tehran, Iran

Royan Research Center, Endocrinology & Infertility Department, Tehran, Iran

Department of Epidemiology and Reproductive Health, Reproductive Medicine Research Center, Rouyan Institute, ACECR, Tehran, Iran

Royan Research Center, Endocrinology & Infertility Department, Tehran, Iran


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Abstract
Introduction: Poor ovarian response to exogenous gonadotrophins occurres in 9-26% of ART cycles. Ovarian reserve decreases by ovarian aging which is an important factor in decreasing ovarian response to gonadotrophins but there are other probable methods which are reported as affecting factors on ovarian response to gonadotrophins such as high dose of gonadotrophins, adjuvant therapy with growth hormone and glucocorticoids. In this study, we aimed to evaluate the role of Dexamethasone, as an effective factor on ovarian response, in infertile women aged over 35 years who referred to Royan institute. Material and methods: In this clinical trial, 72 infertile women, aged over 35 years, who referred to Royan institute to undergo IVF/ICSI program, were selected. Patient were divided into two groups in each group, 36 patients were studied. Laboratory tests including serum FSH, LH, Total Testosterone, Estradiol, Prolactin and thyroid function tests were performed on third day of menstrual cycle. Standard long protocol began on 21st day of menstrual cycle. Simultaneously, in triple blind method, each woman received either 2 tablets containing Dexamethasone or placebo. After 2 weeks, ovarian stimulation was started using 3 HMG ampoules from 2nd day of menstrual cycles and its dose was increased according to ovarian response. If the size of at least three follicles was more than 18 mm, HCG (10000 IU) was administrated after Estradiol measurement. After 36-38 hours of HCG administration, oocyte was retrieved by transvaginal sonography guidance. Embryo transfer was done after 48 hours. SPSS version 11.5 was used for data entry and results were analyzed by Paired t test and Chi-square. P v<0.05 was considered as significant statistical level. Results: There were no statistical differences between the groups in age, duration of infertility, Body mass Index (BMI), hormonal tests, number of retrieved oocyte and percent of transferred embryos. However, the difference between the groups in the number of used HMG ampoules [in Dexamethasone group 30.6±13.39 versus 41.65±18.34 in placebo group] was statistically significant (P<0.05). Conclusion: Although there was no statistical difference between Dexamethasone and placebo groups in number of retrieved and fertilized oocytes but the number of used HMG ampoules in Dexamethasone group was statistically lower than the placebo group and this difference can imply the positive effect of Dexamethasone on ovarian response to gonadotrophins so that utilization of Dexamethasone as an adjuvant for standard treatment is recommended in patients over 35 years old who are known at risk of low ovarian response.

Keywords: Dexamethasone, Ovarian response, Placebo, Assisted Reproductive Techniques, Gonadotropin


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