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Skip Navigation LinksJRI > Archive > January-March 2000, Volume 1, Issue 1 > Functional Investigation of Granulated Lymphocytes in Human Decidua



Volume 1, Issue 1, Number 1 / January-March
(pages 31-35)


Functional Investigation of Granulated Lymphocytes in Human Decidua




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Department of Immunology, Ahwaz Medical Science University, Ahvaz, Iran


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Abstract
Introduction: Introduction: Leucocytes accounted for 26-36% of the stromal cells in decidua of the first trimester of gestation in which 75% of them is related to endometrial granulated lymphocytes (eGL) with an unusual natural killer (NK) cell-like phenotype. Different roles are proposed for eGL, but fundamental role of these cells in control for normrly underestood. Material and Methods: In this study immunosuppressive activity of supernatants prepared from ten sample of normal first trimester decidua which cultured into cell suspension and corresponding purified eGL were investigated using. PHA-induced lymphoproliferation assay. Results: The results showed that although supernatants from purified 24 hours eGL at 50% concentration tended to show increased immunosuppressive activity compared with the corresponding unfractionated cell suspension supernatants, the results did not reach significance.. Conclusion: It seems eGL can mediate immunosuppression activeity in human uterus, but whether this activity is crucial for survival of feto-placental unit real pregnancy is not cleare. more investigation in pathological pregnancy.

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References
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