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Skip Navigation LinksJRI > Archive > April-June 2007, Volume 8, Issue 1 > Clinical effects of Foeniculum vulgare extract on primary dysmenorrhea



Volume 8, Issue 1, Number 30 / April-June
(pages 45-51)


Clinical effects of Foeniculum vulgare extract on primary dysmenorrhea




 Corresponding Author
Department of Midwifery, Faculty of Nursing and Midwifery, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

Department of Midwifery, Faculty of Nursing and Midwifery, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

Pharmaceutical Sciences Research Center (PSRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran

Department of Biostatistics, Faculty of Paramedical, Shahid Beheshti University of Medical Sciences, Tehran, Iran


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Abstract
Introduction: Primary dysmenorrhea (PD) is seen in more than 95% of women of childbearing years. PD causes absence from school and workplace and has annually resulted in 600 million work-hours of absenteeism and two billion dollars of financial loss in America. Considering the known side-effects of chemical drugs in the management of primary dysmenorrhea, and the use of Foeniculum vulgare (FV) in traditional medicine practices as an energizing, tranquilizing and anti-spasmodic medicinal herb, this study was done to determine the effects of FV’s extract on the reduction of pain and other systemic symptoms accompanying PD in female students at Shahid Beheshti University in 2005. Materials & Methods: In this double-blind clinical trial, 90 randomly selected subjects diagnosed with PD were studied (46 cases and 44 controls). Five capsules containing 46 mg of Foeniculum vulgare and identical placebos were provided to be taken daily by the case and control groups respectively, during the first three days following the onset of dysmenorrheal pain whenever they needed the medications. Severity of dysmenorrheal and systematic symptoms were assessed and compared before the study and during two consecutive menses with Andersch and Milsoms verbal multidimensional scoring system. The results were analyzed by SPSS (Version 10) through calculations of Friedman test, non-parametric repeated measures, and Mann-Whitney test to compare the two groups. Results: Severity of pain in the treated group with Foeniculum vulgare extract in comparison with the placebo group, showed a significant statistical difference (p<0.001). Despite a reduction in the severity of systemic symptoms in both groups, statistically significant differences were not observed considering systemic symptoms except for fatigue within borderline limits (p=0.058). Conclusion: In accordance to the results of this study, it seems that Foeniculum vulgare extract can be effective in reducing the severity of dysmenorrhea. More research with larger sample sizes and longer periods of time are required to confidently declare the mentioned results.

Keywords: Primary dysmenorrhea, Foeniculum vulgare, Systemic symptoms, Pain, Medicinal herb, Puberty, Menstruation


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References
  1. Ryan K. Kistner's Gynecology. 6th Edition. NewYork. Years book INC. Medical publisher. 1999; pp:342.
  2. Berek J. Novak's Gynecology. 13th Edition. Williams & Wilkins Company. 2002;pp:823.
  3. Scott J. Danforth's Obstetrics and Gynecology. 9th Edition. Williams & Wilkins Company. 2003;pp:523.
  4. سرگلزايي محمد رضا‌، كيخايي ناهید‌. ديسمنوره‌ و ورزش‌ بانوان‌. فصلنامه‌ علمي‌ ـ پژوهشي‌ دانشگاه‌ علوم‌ پزشكي‌ ياسوج‌. سال3 شماره11 و 12. 1377.
  5. Howard F. Pelvic pain diagnosis & management. Wil-liam & Wilkins Company. 2000;pp:212.
  6. Doty E. Managing primary dysmenorrhea. J Pediatr Adolesc Gynecol. 2006;19:341-4.   [PubMed]
  7. Hsua C.S. Effect of ‘‘Dang-Qui-Shao-Yao-San’’ a Chi-nese medicinal prescription for dysmenorrhea on uterus contractility in vitro. Phytomedicine. 2006;13:94-100.   [PubMed]
  8. Speroff L, Fritz MA. Clinical gynecologic endocrine-logy and infertility. 7th Edition. Williams & Wilkin Company. 2005;pp:342.
  9. حويزي علی‌. بيماريها و درمان‌ گياهي‌. چاپ‌ اول‌. تهران‌. نشر آفتاب‌. 1370. صفحات 154-260.
  10. ميرحيدر حسین. معارف‌ گياهي‌، كاربرد گياهان‌ در پيشگيري‌ و درمان‌ بيماريها. چاپ‌ دوم. جلد دوم. تهران. نشر فرهنگ‌ اسلامي‌. 1375. صفحات234-238.
  11. زرگري‌ علی‌. گياهان‌ دارويي‌. چاپ‌ پنجم‌. جلد دوم‌. تهران‌. انتشارات‌ دانشگاه‌ تهران‌.1370. صفحات 323-330.
  12. Khorshidi N. Clinical effects of essential oil on pri-mary dysmenorrhea. Iranian J Pharmaceut Sci. 2003;2: 89-93.
  13. Namavar B., Tartifizadeh A., Khabnadideh S. Compa-rison of Fennel and Mefenamic acid for the treatment of primary dysmenorrhea. Int Fed Gynecol Obstet. 2003;80(2):153-7.   [PubMed]
  14. Ostad SN, Soodi M, Shariffzadeh M, Khorshidi N, Marzban H. The effect of Fennel essential oil on uterine contraction as a model for dysmenorrheal, phar-macology and toxicology study. J Ethnopharmacol. 2000;76:299-304.   [PubMed]
  15. Andresch B, Milsom I. An epidemiologic study of young women with dysmenorrhea. Am J Obstet Gyne-col. 1982;144(6):655-660.   [PubMed]
  16. Alexandrovich I. The effect of fennel (Foeniculum Valgare) seed oil emulsion in infantile colic. Alternate Therap Health Med. 2003;9(4):58.   [PubMed]
  17. Decherney A.H. Current obstetrics & gynecologic diagnosis & treatment. 9th Edition. New York. Mc Grow-Hill. 2003;pp:342.
  18. حجازي‌ شیرین‌. بررسي‌ مقايسه‌اي‌ تأثير داروهاي‌ گياهي‌ و شيميايي‌ بر ديسمنوره‌اوليه‌ در دانشجويان‌ ساكن‌ در خوابگاه هاي‌ دانشگاه‌ علوم‌ پزشكي‌ بوشهر در سال‌ 1381. نشريه‌ دانشكده‌ پرستاري‌ و مامايي‌ دانشگاه‌ علوم‌ پزشكي‌ و خدمات‌ بهداشتي‌ـ درماني‌ شهيد بهشتي‌. سال 13. شماره 43. 1381.2005;(6)463-471.
  19. Lobo RA. Potential options for preservation of ferti-lity in women. N Engl J Med. 2005;353(1):64-73.
  20. Papadimitrou DS, Martin-Hirsch P, Kitchener HC, Lolis DE, Dalkalitsis N, Paraskevaidis E. Recurrent borderline ovarian tumours after conservative manage-ment in women wishing to retain their fertility. Eur J Gynecol Oncol. 1999;2:94-7.
  21. Longacre TA, Mckenney JK, Tazelaer Hb. Ovarian serous tumors of low malignant (borderline tumors). Outcome-based study of 276 patients with long term follw-up. Am J Surg Pathol. 2002;29(6):707-23.



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