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Skip Navigation LinksJRI > Archive > April-June 2000, Volume 1, Issue 2 > The Reversible Effect of Cimetidine on Number and Motility rat Spermatozoa



Volume 1, Issue 2, Number 2 / April-June
(pages 69-76)


The Reversible Effect of Cimetidine on Number and Motility rat Spermatozoa




 Corresponding Author
Department of physilolgy, Medicin faculty, Shiraz Medical Sciences University, Shiraz, Iran

Department of physilolgy, Medicin faculty, Shiraz Medical Sciences University, Shiraz, Iran


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Abstract
This study carried out to investigate the reversible effect of cimetidine on: Sperm count and Sperm motility in male rat. 80 mature male Charles River rats (285 - 315 gr) divided in to 8 groups: blank (G1), received no treatment at all, control, received 100 mg / kg / day normal saline IP for 5 weeks (G2).The other six groups received 100 mg / kg / day cimetidine IP for 1 Week (G3), 2 weeks (G4), 3 weeks (G5), 4 weeks (G6), 5 weeks (G7) 6 weeks (G8). However G8 during the last sixth week received notreatment. When the animal was anesthetized sperm samples taken from vasdeferens to investigate its motility and counts.Results revealed that sperm count decreased in the test compare to control and blank groups and nonmotile sperm increased in test (G3- G7) compare to control groups. However in G8 which sperm count and motility were analyzed one week after termination of cimetidine injection there were no significant differences in this parameter between controls and test. So the effect of cimetidine on sperm count and motility is reversible. We concluded that the reduction in sperm count and motility may be due to the direct effect of cimetidine on seminiferus tubules, which is reversible.

Keywords: Rat, Cimetidine, Sperm, Spermatogenesis


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References
  1. Acosta AA, Swanson RJ, Ackerma SB, Kruger TF, Vanzyl JA, Menkveld R. Human spermatozoa in Assisted Reproduction. WILLIAMS & WILKINS. 1990;pp:74-75.
  2. Apgar J, Zinc and reproduction, Ann. Rev. Nutr. 1985;5:43-68.
  3. Bokalkin GY, Isibezoy VV, Sjutkin EA, Veselovea SP, Novilov ID, Vribosheev DG. Latralization of LHRH in the rat hypothalamus. Brain. Res. 1984;296:361-364.
  4. Claude K, Lardinois MD, Ernest L, Mazzaferri MD. Cimetidine blocks testosterone synthsis. Arch intern med. 1985;145:920-922.
  5. Cruz ME. Moran JC, Jaramilo CP, Dominguez R. Effects of unilaterai lesion in the anterior hypothalamas on spontaneous ovutation in both normal of the mispayed rats. Biology of Reprod. Supplcment. 1988;38:189.
  6. Gerendai I, Rotsytein W, Marchetti B, Scapagnini V. LHRH content changes in the mediobasal hypothalamus after unitateral ovariectomy. In A Polleri and R. Mackod, Neuroen do crinolgoy: Bilogical and clinical Aspects. Proceedign of Sereno symposia Academia press, New York. 1974;19:97-102.
  7. فريناز نصيري نژاد، بررسي هسته قدامي هيپوتالاموس در ارتباط با كنترل نامتقارن آن بر تنظيم عمل بيضه‌ها، مراكز سير و گرسنگي و مركز تنظيم درجه حرارت در موش صحرائي نر پايان نامه كارشناسي ارشد فيزيولوژي انساني، 1372.
  8. فريناز نصيري نژاد، گيتي دخت نيري كمان و مسعود ستوده، چگونگي كنترل هيپوتالاموس بر تنظيم عمل بيضه‌ها ارائه و چاپ در هفتمين كنگره بين‌المللي پزشكي جغرافيائي دانشگاه علوم پزشكي شيراز 1373.
  9. فريناز نصيري نژاد و گيتي دخت نيري كمان. برتري هسته قدامي راست هيپوتالاموس بر چپ در كنترل ترشح تستوسترون. دوازدهمين كنگره فيزيولوژي و فارماكولوژي ايران 1374. صفحه 84.
  10. Nance DM, Bharganam and Mybit GA. Futher evidence for hypothalamic asymmetry in endocrine control of the ovary.
  11. Nayeri Kaman GD, Nasiri Nejad F. The possibility of hypothalamic anterior function in asymmetric control of testieular Function. Novel foats in neuroen-docrinology. A Stellitic symposium of the third Congress of Faops. Nov 13-14X lan, china. 1944;pp:33.
  12. Nayeri Kaman GD, Kazerooni M, Kumar PVN. Effects of Cimetidine on reproductive system activity in male rat. 11th Znternational congress of Geographic medicine shiraz, Iran. 1998;pp:135.
  13. Nayeri Kaman, Kazerooni M. Cimetidine and sperm. 14th Iranian Congress of Physiology and Pharmacology. Congress Abstract. 1999;pp:217.
  14. Stphen J, Winters MD, James L, Banks AB, and D. Lynn loriaux MD. Cimetidine is an antianderogen in the rat. Gastroenterology. 1978;76:504.
  15. Van Thiel DH, Gavaler JS, Smith WI, Paul G. The New England Journal of Medicine. 1979;300:1012-1015.
  16. Van Thiel DH, Cavaler JS, Heyla & Susen B. An evaluation of the antiandrogen effects associated with H2 antagonist therapy. Scand Journal. Gastroenterol. Supplement. 1987;22(136):24-28.



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