ARI 
 JRI 
 ISERB 
blogger delicious digg diigo facebook googleplus linkedin netlog reddit twitter
Skip Navigation LinksJRI > Archive > January-March 2009, Volume 9, Issue 4 > Serum Homocysteine Levels in PCOS Patients versus Healthy Women



Volume 9, Issue 4, Number 37 / January-March
(pages 334-341)


Serum Homocysteine Levels in PCOS Patients versus Healthy Women




 Corresponding Author
Vali-e- Asar Reproductive Health Research Center,Tehran Medical Sciences University, Tehran, Iran

Endocrinology and Metabolism Research Center (EMRC), Tehran University of Medical Sciences, Tehran, Iran

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Vali-e- Asar Reproductive Health Research Center,Tehran Medical Sciences University, Tehran, Iran

Vali-e- Asar Reproductive Health Research Center,Tehran Medical Sciences University, Tehran, Iran

Endocrinology and Metabolism Research Center (EMRC), Tehran University of Medical Sciences, Tehran, Iran

Vali-e- Asar Reproductive Health Research Center,Tehran Medical Sciences University, Tehran, Iran

Endocrinology and Metabolism Research Center (EMRC), Tehran University of Medical Sciences, Tehran, Iran

Received: 10/5/2008 Accepted: 1/10/2009

Related Articles
in Google Scholar in PubMed

 

Other Format
pdfPDF Full Text (En) pdfPDF Full Text (Fa) pdfePUB Full Text (En) pdfPDF Abstract (En) pdfPDF Abstract (Fa) pdf BibTeX pdfRefMan pdfEndNote xmlPMC XML online readerPMC Reader

 


Abstract
Introduction: Patients with PCOS have risk factors for cardiovascular diseases, especially elevated lipoproteins, high blood pressure or hyperinsulinaemia. Clinical evidence shows that hyperhomocysteinaemia may contribute to the development of cardiovascular diseases in PCOS patients. In this study we compared serum homocysteine levels in PCOS patients with healthy Iranian women.Materials and Methods: This case-control study was performed on 52 individuals with PCOS (Rotterdam 2003 criteria). The cases were compared to 104 healthy non-PCOS, 20 to 35-year-old female subjects with no history of diabetes or renal diseases. The cases had referred to the Gynecology and Infertility Clinic of Vali-e-Asr Hospital in Tehran. Blood samples were taken on the 2nd to the 5th day of menstrual cycle for the evaluation of homocysteine levels, folic acid, triglyceride, insulin and some other metabolic and endocrine parameters.Results: Serum levels of insulin and folate were significantly higher in PCOS patients (16.62±7.45IU/ml and 7.48±4.37ng/ml) compared to the controls (12.04±4.23IU/ml and 5.43±3.15ng/ml), (p<0.001). Serum triglyceride concentrations were significantly higher in PCOS patients (116.62±73.02mg/dl) compared to the healthy subjects (88.00±50.29mg/dl), (p=0.01). The mean value for homocysteine (±SD) was 12.21 (±4.55) and 13.68 (±4.37)mol/L in PCOS and healthy women, respectively but no significant statistical differences were observed (p=0.057). Regression analyses depicted that homocysteine level was mostly under the influence of folate and FBS concentrations.Conclusion: There is an inverse correlation between homocysteine and serum folic acid levels in PCOS patients. Therefore, it seems that proper administration of folic acid can reduce homocysteine levels in patients with PCOS and help prevent the attributed cardiovascular risk factors associated with the disease.

Keywords: Female infertility, Folic acid, Homocysteine, Polycystic ovary syndrome


To cite this article:



Figures, Charts, Tables

References
  1. Cattrall FR, Healy DL. Long-term metabolic, cardio-vascular and neoplastic risks with polycystic ovary syndrome Best Pract Res Clin Obstet Gynaecol. 2004; 18(5): 803-12.   [PubMed]
  2. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syn-drome (PCOS). Hum Reprod. 2004; 19(1): 41-7.   [PubMed]
  3. Polson DW, Adams J, Wads Worth J, Franks S. Poly cystic ovaries-a common finding in normal woman. Lancet. 1988; 870-2.   [PubMed]
  4. Atamer A, Demir B, Bayhan G, Atamer Y, Ilhan N, Akku? Z. Serum levels of leptin and homocysteine in women with polycystic ovary syndrome and its rela-tionship to endocrine, clinical and metabolic param-eters. J Int Med Res. 2008; 36(1): 96-105.   [PubMed]
  5. Herrmann W. The importance of hyperhomocysteinemia as a risk factor for diseases: overview. Clin Chem Lab Med. 2001; 39(8): 666-74.   [PubMed]
  6. Hoque MM, Bulbul T, Mahal M, Islam NA, Ferdausi M. Serum homocysteine in pre-eclampsia and eclamp-sia. Bangladesh Med Res Counc Bull. 2008; 34(1): 16-20.   [PubMed]
  7. Vollset SE, Refsum H, Irgens LM, Emblem BM, Tverdal A, Gjessing HK, et al. Plasma total homo-cysteine, pregnancy complications, and adverse preg-nancy outcomes: the Hordaland Homocysteine study. Am J Clin Nutr. 2000; 71(4): 962-8.   [PubMed]
  8. Gillum R. Distribution of serum total homocysteine and its association with diabetes and cardiovascular risk factors of the insulin resistance syndrome in Mexican American men: the Third National Health and Nutri-tion Examination Survey. Nutr J. 2003; 5: 2(1): 6.   [PubMed]
  9. Wijeyaratne CN, Nirantharakumar K, Balen AH, Barth JH, Sheriff R, Belchetz PE. Plasma homocysteine in polycystic ovary syndrome: does it correlate with insu-lin resistance and ethnicity? Clin Endocrinol. 2004; 60(5): 560-7.   [PubMed]
  10. Refsum H. Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome. Br J Nutr. 2001; 85 Suppl 2: 109-13.   [PubMed]
  11. Budde MP, De Lange TE, Dekker GA, Chan A, Nguyen AM. Risk factors for placental abruption in a socio-economically disadvantaged region. J Matern Fetal Neonatal Med. 2007; 20(9): 687-93.   [PubMed]
  12. Yilmaz N, Pektas M, Tonguc E, Kilic S, Gulerman C, Gungor T. The correlation of plasma homocysteine with insulin resistance in polycystic ovary syndrome. J Obstet Gynaecol Res. 2008; 34(3): 384-91.   [PubMed]
  13. Vrb?kov? J, Tallov? J, Bicikov? M, Dvor?kov? K, Hill M, St?rka L. Plasma thiols and androgen levels in Poly Cystic ovary syndrome. Clin Chem Lab Med. 2003; 41(2): 216-21.   [PubMed]
  14. Oktem M, Ebru Ozcimen E, Uckuyu A, Esinler I, Pamuk B, Bayraktar N, et al. Polycystic ovary syn-drome is associated with elevated plasma soluble CD40 ligand, a marker of coronary artery disease. Fertil Steril. 2008; [Epub ahead of print].   [PubMed]
  15. Kazerooni T, Asadi N, Dehbashi S, Zolghadri J. Effect of folic acid in women with and without insulin resist-ance who have hyperhomocysteinemic polycystic ovary syndrome. Int J Gynaecol Obstet. 2008; 101(2): 156-60.   [PubMed]
  16. De la Calle M, Gallardo T, Diestro MD, Hernanz A, Pérez E, Fern?ndez-Miranda C. [Increased homocysteine levels in polycystic ovary syndrome. Med Clin] (Barc). 2007; 129(8): 292-4. Spanish.   [PubMed]
  17. Guzelmeric K, Alkan N, Pirimoglu M, Unal O, Turan C. Chronic inflammation and elevated homocysteine levels are associated with increased body mass index in women with Polycystic ovary syndrome. Gynecol Endocrinol. 200; 23(9): 505-10.   [PubMed]
  18. Yilmaz M, Biri A, Bukan N, Karakoç A, Sancak B, T?rüner F, Pa?ao?lu H. Levels of lipoprotein and homocysteine in non-obese and obese patients with polycystic ovary syndrome. Gynecol Endocrinol. 2005; 20(5): 258-63.   [PubMed]
  19. Loverro G, Lorusso F, Mei L, Depalo R, Cormio G, Selvaggi L. The plasma homocysteine levels are in-creased in polycystic ovary syndrome. Gynecol Obstet Invest. 2002; 53(3): 157-162.   [PubMed]
  20. Badawy A, State O, El Gawad SSh, El Aziz OA. Plasma homocysteine and polycystic ovary syndrome: the missed link. Eur J Obstet Gynecol Reprod Biol. 2007; 131(1): 68-72.   [PubMed]
  21. Morgante G, La Marca A, Setacci F, Setacci C, Petraglia F, De Leo V. The cardiovascular risk factor homocysteine is not elevated in young women with hyperandrogenism or hypoestrogenism. Gynecol Obstet Invest. 2002; 53(4): 200.   [PubMed]
  22. Mancini F, Cianciosi A, Reggiani GM, Facchinetti F, Battaglia C, de Aloysio D. Endothelial function and its relationship to leptin, homocysteine, and insulin resist-ance in lean and overweight eumenorrheic women and PCOS patients: a pilot study. Fertil Steril. 2008; 5. Epub ahead of print.   [PubMed]



Home | About Us | Current Issue | Past Issues | Submit a Manuscript | Instructions for Authors | Subscribe | Search | Contact Us

"Journal of Reproduction & Infertility" is owned, published, and copyrighted by Avicenna Research Institute .
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

Journal of Reproductoin and Infertility (JRI) is a member of COMMITTEE ON PUBLICATION ETHICS . Verify here .

©2016 - eISSN : 2251-676X, ISSN : 2228-5482, For any comments and questions please contact us.