blogger delicious digg diigo facebook googleplus linkedin netlog reddit twitter
Skip Navigation LinksJRI > Archive > October-December 2000, Volume 1, Issue 4 > Serum and follicular fluid IL-6 and sex steroid hormone levels and their correlation of undergoing IVF-ET with endometriosis and pregnancy rate in women



Volume 1, Issue 4, Number 4 / October-December
(pages 55-62)


Serum and follicular fluid IL-6 and sex steroid hormone levels and their correlation of undergoing IVF-ET with endometriosis and pregnancy rate in women




 Corresponding Author
Biochemistry Department, Tabriz Univarsity of Medical Sciences, Tabriz, Iran

1- Biochemistry Department, Tabriz Univarsity of Medical Sciences, Tehran, Iran
2- Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Infertility Center, Kiel University, Kiel, Germany

Department of Obstet . and Gynecol . of Tabriz University of Medical Science, Tabriz, Iran


Related Articles
in Google Scholar in PubMed

 

Other Format
pdfPDF Full Text (En) pdfPDF Full Text (Fa) pdfePUB Full Text (En) pdfPDF Abstract (En) pdfPDF Abstract (Fa) pdf BibTeX pdfRefMan pdfEndNote xmlPMC XML online readerPMC Reader

 


Abstract
Cytokines Not only do regulate physiological processes, but also play important roles in immunopathological reactions. The aim of this study was to evaluate the correlation between IL-6 and sex hormone levels with endometriosis and pregnancy rate at the time of oocyte retrieval. In infertile women undergoing IVF-ET Eighty patients received ovulation induction drugs and underwent IVF-ET. IL-6 levels in serum and follicular fluid (FF) were measured by ELISA and FSH, estradiol and progesterone by RIA. In 36 out of 80 patients embryos were transferred and pregnancy rate were evaluated after two weeks. The result showed no significant correlation between serum and FF levels of estradiol, progesterone and FSH with pregnancy rate in IVF patients. Similar levels of IL-6 in serum and FF of pregnant and non pregnant patients after embryo transfer were observed (P>0.05). However there was a significant correlation between FF levels of IL-6 in pregnant and non pregnant endometriosis patients (P<0.05). These results indicate that increase of FF levels of IL-6 may be accompanied by pregnancy rate reduction in endometriosis patients.

Keywords: IL-6, Follicular fluid, Sex hormone, Endometriosis, Pregnancy rate, IVF-ET


To cite this article:


References
  1. Mandrup-Poulsen T, Nerup J, Reimers JI, Pociot F, Andersen HU, Karlsen A, Bjerre U, Bergholdt R. Cytokines and the endocrine system. I. The immunoendocrine network. Eur J Endocrinol. 1995, 133(6):660-71.
  2. Adashi EY. The potential relevance of cytokines to ovarian physiology: the emerging role of resident ovarian cells of the white blood cell series. Endocrinol Rev. 1990, 11(3):454-64.
  3. Vinatier D, Dufour P, Tordjeman-Rizzi N, Prolongeau JF, Depret-Moser S, Monnier JC. Immunological aspects of ovarian function: role of the cytokines. Eur J Obstet Gynecol Reprod Biol. 1995, 63(2):155-68.Review.
  4. Hu SK, Mitcho YL, Rath NC. Effect of estradiol on interleukin 1 synthesis by macrophages. Int J Immunopharmacol. 1988, 10(3):247-52.
  5. Polan ML, Loukides JA, Honig J. Interleukin-1 in human ovarian cells and in peripheral blood monocytes increases during the luteal phase: evidence for a midcycle surge in the human.Am J Obstet Gynecol.1994, 170(4):1006-7.
  6. Hirano T, Taga T, Nakano N, Yasukawa K, Kashiwamura S, Shimizu K, Nakajima K, Pyun KH, Kishimoto T. Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). Proc Natl Acad Sci. 1985, 82(16):5490-4.
  7. Akira S, Hirano T, Taga T, Kishimoto T. Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB J. 1990, 4(11):2860-7.
  8. Van Snick J. Interleukin-6: an overview. Annu Rev Immunol. 1990, 8:253-78.
  9. Buscher U, Chen FC, Kentenich H, Schmiady H. Cytokines in the follicular fluid of stimulated and non-stimulated human ovaries; is ovulation a suppressed inflammatory reaction? Hum Reprod. 1999, 14(1):162-6.
  10. Cohen T, Nahari D, Cerem LW, Neufeld G, Levi BZ. Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem. 1996, 271(2):736-41.
  11. Loret de Mola JR, Flores JP, Baumgardner GP, Goldfarb JM, Gindlesperger V, Friedlander MA.Elevated interleukin-6 levels in the ovarian hyperstimulation syndrome: ovarian immunohistochemical localization of interleukin-6 signal. Obstet Gynecol. 1996, 87(4):581-7.
  12. Garrido N, Navarro J, Remohi J, Simon C, Pellicer A. Follicular hormonal environment and embryo quality in women with endometriosis. Hum Reprod Update. 2000, 6(1):67-74.
  13. The American Fertility Society. Revised American Fertility Society classification of endometriosis. Fertil Steril. 1985, 43:351-2.
  14. Koch AE, Polverini PJ, Kunkel SL, Harlow LA, DiPietro LA, Elner VM, Elner SG, Strieter RM. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science. 1992, 11:258(5089):1798-801.
  15. Arici A, Oral E, Bukulmez O, Buradagunta S, Engin O, Olive DL. Interleukin-8 expression and modulation in human preovulatory follicles and ovarian cells. Endocrinology. 1996, 137(9):3762-9.
  16. Keck C, Rajabi Z, Pfeifer K, Bettendorf H, Brandstetter T, Breckwoldt M. Expression of interleukin-6 and interleukin-6 receptors in human granulosa lutein cells. Mol Hum Reprod. 1998, 4(11):1071-6.
  17. Hock DL, Huhn RD, Kemmann E. Leukocytosis in response to exogenous gonadotrophin stimulation.Hum Reprod. 1997, 12(10):2143-6.
  18. Chen CD, Chen HF, Lu HF, Chen SU, Ho HN, Yang YS. Value of serum and follicular fluid cytokine profile in the prediction of moderate to severe ovarian hyperstimulation syndrome. Hum Reprod. 2000, 15(5):1037-42.
  19. Wang LJ, Norman RJ. Concentrations of immunoreactive interleukin-1 and interleukin-2 in human preovulatory follicular fluid. Hum Reprod. 1992, 7(2):147-50.
  20. Motro B, Itin A, Sachs L, Keshet E. Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis. Proc Natl Acad Sci U S A. 1990, 87(8):3092-6.
  21. Simon C, Gutierrez A, Vidal A, de los Santos MJ, Tarin JJ, Remohi J, Pellicer A. Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation. Hum Reprod. 1994, 9(4):725-9.
  22. Sung L, Mukherjee T, Takeshige T, Bustillo M, Copperman AB. Endometriosis is not detrimental to embryo implantation in oocyte recipients. J Assist Reprod Genet. 1997, 14 (3): 152-6.
  23. Pellicer A, Oliveira N, Ruiz A, Remohi J, Simon C. Exploring the mechanism(s) of endometriosis-related infertility: an analysis of embryo development and implantation in assisted reproduction.Hum Reprod. 1995, 10 Suppl 2:91-7.



Home | About Us | Current Issue | Past Issues | Submit a Manuscript | Instructions for Authors | Subscribe | Search | Contact Us

"Journal of Reproduction & Infertility" is owned, published, and copyrighted by Avicenna Research Institute .
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

Journal of Reproductoin and Infertility (JRI) is a member of COMMITTEE ON PUBLICATION ETHICS . Verify here .

©2016 - eISSN : 2251-676X, ISSN : 2228-5482, For any comments and questions please contact us.