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Skip Navigation LinksJRI > Archive > April-June 2011, Volume 12, Issue 2 > Common Techniques for Preserving Fertility in Girls and Young Women Undergoing Cancer Treatment



Volume 12, Issue 2, Number 47 / April-June
(pages 85-92)


Common Techniques for Preserving Fertility in Girls and Young Women Undergoing Cancer Treatment




1- Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2- Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

1- Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2- Cellular & Molecular Research Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Monoclonal Antibody Research Center, Avicenna Research Institute (ACECR), Tehran, Iran

1- Nanobiotechnology Research Center, Avicenna Research Institute (ACECR), Tehran, Iran
2- Immunology Research Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

 Corresponding Author
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Received: 7/22/2010 Accepted: 11/3/2010

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Abstract
Current protocols for cancer treatment could lead to the failure of ovarian function and subsequent infertility in women. Therefore, utilizing ways to preserve fertility in these individuals seem to be essential. In this review, the full-text of articles which were accessible and had been published during 1976 to 2009 about different methods of female fertility preservation were collected and studied through various online databases such as PubMed, Science Direct, etc. According to the reviewed articles, there are several methods for fertility preservation in women, including ovarian transposition and oocyte, embryo and ovarian cortex cryopreservation. Ovarian transposition is not useful for preserving fertility in women who undergo chemo-therapy. Embryo and oocyte cryopreservations require a delay before starting treat-ment. Metaphase II oocytes are high-volume and fully-differentiated cells which may sustain injury due to the freezing process restricting the number of collected oocytes and reducing the chances of fertility. On the other hand, ovarian stimulation and oocyte collection are not practical in young patients, especially in underage girls. In addition to the restrictions on the number of collected embryos and the raised legal and ethical issues, embryo crypreservation is limited to adults and married women. In comparison to other methods, cryopreservation of the ovarian cortex seems to be more appropriate as ovarian tissue is resistant to cryopreservation and it is easy to be collected by laprascopy, making it practical for use in premature girls. Furthermore, the large number of follicles in the ovarian tissue increases the chances of fertility preservation in women. In general, several parameters including the type, time and duration of treatment, cancer type, age and marital status determine the efficacy of each method.

Keywords: Cancer treatment, Embryo cryopreservation, Fertility preservation, Ovarian transposition


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References
  1. Jadoul P, Donnez J, Dolmans MM, Squifflet J, Lengele B, Martinez-Madrid B. Laparoscopic ovaryectomy for whole human ovary cryopreservation: technical aspects. Fertil Steril. 2007;87(4):971-5.
  2. Yang H, Lee HH, Lee HC, Ko DS, Kim SS. Assessment of vascular endothelial growth factor expression and apoptosis in the ovarian graft: can exogenous gonadotropin promote angiogenesis after ovarian transplantation? Fertil Steril. 2008;90(4 Suppl): 1550-8.
  3. Kormi Nouri R, Akhondi MA, Behjati Ardekani Z. Psychological aspects of infertility from viewpoint of infertility treating physicians. J Reprod Infertil. 2001;2(3):13-26.
  4. Frederick JL, Ord T, Kettel LM, Stone SC, Balmaceda JP, Asch RH. Successful pregnancy outcome after cryopreservation of all fresh embryos with subsequent transfer into an unstimulated cycle. Fertil Steril. 1995;64(5):987-90.
  5. Selick CE, Hofmann GE, Albano C, Horowitz GM, Copperman AB, Garrisi GJ, et al. Embryo quality and pregnancy potential of fresh compared with frozen embryos--is freezing detrimental to high quality embryos? Hum Reprod. 1995;10(2):392-5.
  6. Bisharah M, Tulandi T. Laparoscopic preservation of ovarian function: an underused procedure. Am J Obstet Gynecol. 2003;188(2):367-70.
  7. Clough KB, Goffinet F, Labib A, Renolleau C, Campana F, de la Rochefordiere A, et al. Laparoscopic unilateral ovarian transposition prior to irradiation: prospective study of 20 cases. Cancer. 1996; 77(12):2638-45.
  8. Hunter MC, Glees JP, Gazet JC. Oophoropexy and ovarian function in the treatment of Hodgkin's disease. Clin Radiol. 1980;31(1):21-6.
  9. Meirow D, Nugent D. The effects of radiotherapy and chemotherapy on female reproduction. Hum Reprod Update. 2001;7(6):535-43.
  10. Morice P, Juncker L, Rey A, El-Hassan J, HaieMeder C, Castaigne D. Ovarian transposition for patients with cervical carcinoma treated by radiosurgical combination. Fertil Steril. 2000;74(4):743-8.
  11. Feeney DD, Moore DH, Look KY, Stehman FB, Sutton GP. The fate of the ovaries after radical hysterectomy and ovarian transposition. Gynecol Oncol. 1995;56(1):3-7.
  12. Thomas PR, Winstanly D, Peckham MJ, Austin DE, Murray MA, Jacobs HS. Reproductive and endocrine function in patients with Hodgkin's disease: effects of oophoropexy and irradiation. Br J Cancer. 1976;33(2):226-31.
  13. Williams RS, Littell RD, Mendenhall NP. Laparoscopic oophoropexy and ovarian function in the treatment of Hodgkin disease. Cancer. 1999;86 (10):2138-42.
  14. Gabriel DA, Bernard SA, Lambert J, Croom RD 3rd. Oophoropexy and the management of Hodgkin's disease. A reevaluation of the risks and benefits. Arch Surg. 1986;121(9):1083-5.
  15. Chen CH, Zhang X, Barnes R, Confino E, Milad M, Puscheck E, et al. Relationship between peak serum estradiol levels and treatment outcome in in vitro fertilization cycles after embryo transfer on day 3 or day 5. Fertil Steril. 2003;80(1):75-9.
  16. Son WY, Yoon SH, Yoon HJ, Lee SM, Lim JH. Pregnancy outcome following transfer of human blastocysts vitrified on electron microscopy grids after induced collapse of the blastocoele. Hum Reprod. 2003;18(1):137-9.
  17. Senn A, Vozzi C, Chanson A, De Grandi P, Germond M. Prospective randomized study of two cryopreservation policies avoiding embryo selection: the pronucleate stage leads to a higher cumulative delivery rate than the early cleavage stage. Fertil Steril. 2000;74(5):946-52.
  18. Wang JX, Yap YY, Matthews CD. Frozen-thawed embryo transfer: influence of clinical factors on implantation rate and risk of multiple conception. Hum Reprod. 2001;16(11):2316-9.
  19. Oktay K, Kan MT, Rosenwaks Z. Recent progress in oocyte and ovarian tissue cryopreservation and transplantation. Curr Opin Obstet Gynecol. 2001; 13(3):263-8.
  20. Chen C. Pregnancy after human oocyte cryopreservation. Lancet. 1986;1(8486):884-6.
  21. Oktay K, Newton H, Mullan J, Gosden RG. Development of human primordial follicles to antral stages in SCID/hpg mice stimulated with follicle stimulating hormone. Hum Reprod. 1998;13(5): 1133-8.
  22. Torrents E, Boiso I, Barri PN, Veiga A. Applications of ovarian tissue transplantation in experi-mental biology and medicine. Hum Reprod Update. 2003;9(5):471-81.
  23. Boldt J, Tidswell N, Sayers A, Kilani R, Cline D. Human oocyte cryopreservation: 5-year experience with a sodium-depleted slow freezing method. Reprod Biomed Online. 2006;13(1):96-100.
  24. Stachecki JJ, Cohen J. An overview of oocyte cryopreservation. Reprod Biomed Online. 2004;9 (2):152-63.
  25. Borini A, Sciajno R, Bianchi V, Sereni E, Flamigni C, Coticchio G. Clinical outcome of oocyte cryopreservation after slow cooling with a protocol utilizing a high sucrose concentration. Hum Reprod. 2006;21(2):512-7.
  26. Van der Elst J. Oocyte freezing: here to stay? Hum Reprod Update. 2003;9(5):463-70.
  27. Fabbri R, Porcu E, Marsella T, Rocchetta G, Venturoli S, Flamigni C. Human oocyte cryopreservation: new perspectives regarding oocyte survival. Hum Reprod. 2001;16(3):411-6.
  28. Gook DA, Schiewe MC, Osborn SM, Asch RH, Jansen RP, Johnston WI. Intracytoplasmic sperm injection and embryo development of human oocytes cryopreserved using 1,2-propanediol. Hum Reprod. 1995;10(10):2637-41.
  29. Porcu E, Fabbri R, Seracchioli R, Ciotti PM, Magrini O, Flamigni C. Birth of a healthy female after intracytoplasmic sperm injection of cryopreserved human oocytes. Fertil Steril. 1997;68 (4):724-6.
  30. Pickering SJ, Braude PR, Johnson MH, Cant A, Currie J. Transient cooling to room temperature can cause irreversible disruption of the meiotic spindle in the human oocyte. Fertil Steril. 1990; 54(1):102-8.
  31. Albertini DF, Eppig JJ. Unusual cytoskeletal and chromatin configurations in mouse oocytes that are atypical in meiotic progression. Dev Genet. 1995; 16(1):13-9.
  32. Ghetler Y, Yavin S, Shalgi R, Arav A. The effect of chilling on membrane lipid phase transition in human oocytes and zygotes. Hum Reprod. 2005;20 (12):3385-9.
  33. Vajta G, Holm P, Kuwayama M, Booth PJ, Jacobsen H, Greve T, et al. Open Pulled Straw (OPS) vitrification: a new way to reduce cryoinjuries of bovine ova and embryos. Mol Reprod Dev. 1998;51(1):53-8.
  34. Katayama KP, Stehlik J, Kuwayama M, Kato O, Stehlik E. High survival rate of vitrified human oocytes results in clinical pregnancy. Fertil Steril. 2003;80(1):223-4.
  35. Mandelbaum J, Anastasiou O, Lévy R, Guérin JF, de Larouzière V, Antoine JM. Effects of cryopreservation on the meiotic spindle of human oocytes. Eur J Obstet Gynecol Reprod Biol. 2004;113 Suppl 1:S17-23.
  36. Yoon TK, Chung HM, Lim JM, Han SY, Ko JJ, Cha KY. Pregnancy and delivery of healthy infants developed from vitrified oocytes in a stimulated in vitro fertilization-embryo transfer program. Fertil Steril. 2000;74(1):180-1.
  37. Park SE, Son WY, Lee SH, Lee KA, Ko JJ, Cha KY. Chromosome and spindle configurations of human oocytes matured in vitro after cryopreservation at the germinal vesicle stage. Fertil Steril. 1997;68(5):920-6.
  38. Boiso I, Martí M, Santaló J, Ponsá M, Barri PN, Veiga A. A confocal microscopy analysis of the spindle and chromosome configurations of human oocytes cryopreserved at the germinal vesicle and metaphase II stage. Hum Reprod. 2002;17(7): 1885-91.
  39. Wu J, Zhang L, Wang X. In vitro maturation, fertilization and embryo development after ultrarapid freezing of immature human oocytes. Reproduction. 2001;121(3):389-93.
  40. Cha KY, Chian RC. Maturation in vitro of imamture human oocytes for clinical use. Hum Reprod Update. 1998;4(2):103-20.
  41. Trounson A, Wood C, Kausche A. In vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients. Fertil Steril. 1994;62(2): 353-62.
  42. Tucker MJ, Wright G, Morton PC, Massey JB. Birth after cryopreservation of immature oocytes with subsequent in vitro maturation. Fertil Steril. 1998;70(3):578-9.
  43. Kan A, Kilani S, Tilia L, Mitchell F, Burns K, Chapman M. Pregnancy from intracytoplasmic injection of a frozen-thawed oocyte. Aust N Z J Obstet Gynaecol. 2004;44(3):262-3.
  44. Fadini R, Brambillasca F, Renzini MM, Merola M, Comi R, De Ponti E, et al. Human oocyte cryopreservation: comparison between slow and ultrarapid methods. Reprod Biomed Online. 2009;19 (2):171-80.
  45. Kim SS. Fertility preservation in female cancer patients: current developments and future directions. Fertil Steril. 2006;85(1):1-11.
  46. Gosden RG, Baird DT, Wade JC, Webb R. Restoration of fertility to oophorectomized sheep by ovarian autografts stored at -196 degrees C. Hum Reprod. 1994;9(4):597-603.
  47. Liu J, Van der Elst J, Van den Broecke R, Dhont M. Live offspring by in vitro fertilization of oocytes from cryopreserved primordial mouse follicles after sequential in vivo transplantation and in vitro maturation. Biol Reprod. 2001;64(1):171-8.
  48. Sztein J, Sweet H, Farley J, Mobraaten L. Cryopreservation and orthotopic transplantation of mouse ovaries: new approach in gamete banking. Biol Reprod. 1998;58(4):1071-4.
  49. Almodin CG, Minguetti-Câmara VC, Meister H, Ferreira JO, Franco RL, Cavalcante AA, et al. Recovery of fertility after grafting of cryopreserved germinative tissue in female rabbits following radiotherapy. Hum Reprod. 2004;19(6):1287-93.
  50. Candy CJ, Wood MJ, Whittingham DG. Follicular development in cryopreserved marmoset ovarian tissue after transplantation. Hum Reprod. 1995;10 (9):2334-8.
  51. Salle B, Demirci B, Franck M, Rudigoz RC, Guerin JF, Lornage J. Normal pregnancies and live births after autograft of frozen-thawed hemiovaries into ewes. Fertil Steril. 2002;77(2):403-8.
  52. Radford JA, Lieberman BA, Brison DR, Smith AR, Critchlow JD, Russell SA, et al. Orthotopic reimplantation of cryopreserved ovarian cortical strips after high-dose chemotherapy for Hodgkin's lymphoma. Lancet. 2001;357(9263):1172-5.
  53. Demeestere I, Simon P, Buxant F, Robin V, Fernandez SA, Centner J, et al. Ovarian function and spontaneous pregnancy after combined heterotopic and orthotopic cryopreserved ovarian tissue transplantation in a patient previously treated with bone marrow transplantation: case report. Hum Reprod. 2006;21(8):2010-4.
  54. Donnez J, Dolmans MM, Demylle D, Jadoul P, Pirard C, Squifflet J, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;364(9443):1405-10.
  55. Meirow D, Levron J, Eldar-Geva T, Hardan I, Fridman E, Zalel Y, et al. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. N Engl J Med. 2005;353(3):318-21.
  56. Schmidt KL, Andersen CY, Loft A, Byskov AG, Ernst E, Andersen AN. Follow-up of ovarian function post-chemotherapy following ovarian cryopreservation and transplantation. Hum Reprod. 2005; 20(12):3539-46.
  57. Jeruss JS, Woodruff TK. Preservation of fertility in patients with cancer. N Engl J Med. 2009;360(9): 902-11.
  58. Nottola SA, Camboni A, Van Langendonckt A, Demylle D, Macchiarelli G, Dolmans MM, et al. Cryopreservation and xenotransplantation of human ovarian tissue: an ultrastructural study. Fertil Steril. 2008;90(1):23-32.
  59. Nisolle M, Casanas-Roux F, Qu J, Motta P, Donnez J. Histologic and ultrastructural evaluation of fresh and frozen-thawed human ovarian xenografts in nude mice. Fertil Steril. 2000;74(1):122-9.
  60. Aubard Y, Piver P, Cogni Y, Fermeaux V, Poulin N, Driancourt MA. Orthotopic and heterotopic autografts of frozen-thawed ovarian cortex in sheep. Hum Reprod. 1999;14(8):2149-54.
  61. Fain-Kahn V, Poirot C, Uzan C, Prades M, Gouy S, Genestie C, et al. Feasibility of ovarian cryopreservation in borderline ovarian tumours. Hum Reprod. 2009;24(4):850-5.
  62. Hemmati Sh, Zarnani AH, Mahmoudi AR, Sadeghi MR, Soltanghoraee H, Akhondi MA, et al. Ectopic expression of Sortilin 1 (NTR-3) in patients with ovarian carcinoma. Avicenna J Med Biotech 2009; 1(2):125-31.



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