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Skip Navigation LinksJRI > Archive > April-June 2011, Volume 12, Issue 2 > Fertility Preservation in Men after Cancer Treatment; a Review Article



Volume 12, Issue 2, Number 47 / April-June
(pages 73-84)


Fertility Preservation in Men after Cancer Treatment; a Review Article




Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Nanobiotechnology Research Center, Avicenna Research Institute (ACECR), Tehran, Iran

Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Monoclonal Antibody Research Center, Avicenna Research Institute (ACECR), Tehran, Iran

 Corresponding Author
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Received: 4/20/2010 Accepted: 6/30/2010

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Abstract
Some cases of male infertility are due to the destructive side-effects of anticancer treatment methods such as chemo and radiotherapies on germ cell lines. The increase in the survival rate of cancer patients who undergo treatment, especially children, has drawn attention to fertility preservation. The most common and effective technique in preserving male fertility is sperm freezing and its subsequent IVF. Children cannot efficiently produce sperm because of their spermatogonial immaturity. One of the strategies to maintain fertility in these patients is to preserve the testes or the germ cells by freezing them for their later maturation and production of fertile sperm, although the state in which the spermatogonia may not undergo maturation is one of the main obstacles faced in this method. Therefore, scientists have attempted to transplant cryopreserved testis tissues or produce in vitro-matured spermatozoa in this group of patients upon anticancer treatment. In this study we reviewed the germ cell biology, the side-effects of chemo and radiotherapies on germ cells and fertility preservation techniques in adults and children undergoing anticancer treatment.

Keywords: Chemotherapy, Cryopreservation, Fertility preservation, Germ cell transplantation, Radiotherapy, Spermatogonial transplantation


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References
  1. Robey PG. Stem cells near the century mark. J Clin Invest. 2000;105(11):1489-91.
  2. Cowen C, Melton D. Stemness: Definitions, Criteria, and Standards. In: Lanza RP, Hogan B, Melton D, Pedersen R, editors. Essentials of stem cell biology. Burlington: Elsevier Academic Press; 2006.
  3. Simorangkir DR, Marshall GR, Ehmcke J, Schlatt S, Plant TM. Prepubertal expansion of dark and pale type A spermatogonia in the rhesus monkey (Macaca mulatta) results from proliferation during infantile and juvenile development in a relatively gonadotropin independent manner. Biol Reprod. 2005;73(6):1109-15.
  4. van Alphen MM, van de Kant HJ, de Rooij DG. Repopulation of the seminiferous epithelium of the rhesus monkey after X irradiation. Radiat Res. 1988; 113(3):487-500.
  5. Dettin L, Ravindranath N, Hofmann MC, Dym M. Morphological characterization of the spermatogonial subtypes in the neonatal mouse testis. Biol Reprod. 2003;69(5):1565-71.
  6. Wistuba J, Schrod A, Greve B, Hodges JK, Aslam H, Weinbauer GF, et al. Organization of seminiferous epithelium in primates: relationship to spermatogenic efficiency, phylogeny, and mating system. Biol Reprod. 2003;69(2):582-91.
  7. Johnson L, Staub C, Neaves WB, Yanagimachi R. Live human germ cells in the context of their spermatogenic stages. Hum Reprod. 2001;16(8):1575-82.
  8. Ehmcke J, Wistuba J, Schlatt S. Spermatogonial stem cells: questions, models and perspectives. Hum Reprod Update. 2006;12(3):275-82.
  9. Craft I, Bennett V, Nicholson N. Fertilising ability of testicular spermatozoa. Lancet. 1993;342(8875): 864.
  10. Thomson AB, Campbell AJ, Irvine DC, Anderson RA, Kelnar CJ, Wallace WH. Semen quality and spermatozoal DNA integrity in survivors of childhood cancer: a case-control study. Lancet. 2002; 360(9330):361-7.
  11. de Rooij DG, van de Kant HJ, Dol R, Wagemaker G, van Buul PP, van Duijn-Goedhart A, et al. Long-term effects of irradiation before adulthood on reproductive function in the male rhesus monkey. Biol Reprod. 2002;66(2):486-94.
  12. Howell SJ, Shalet SM. Spermatogenesis after cancer treatment: damage and recovery. J Natl Cancer Inst Monogr. 2005;(34):12-7.
  13. Shalet SM, Tsatsoulis A, Whitehead E, Read G. Vulnerability of the human Leydig cell to radiation damage is dependent upon age. J Endocrinol. 1989; 120(1):161-5.
  14. Sabanegh ES Jr, Ragheb AM. Male fertility after cancer. Urology. 2009;73(2):225-31.
  15. Hudson MM. Survivors of childhood cancer: coming of age. Hematol Oncol Clin North Am. 2008; 22(2):211-31.
  16. Heindel JJ. Role of exposure to environmental chemicals in the developmental basis of reproductive disease and dysfunction. Semin Reprod Med. 2006;24(3):168-77.
  17. Lawson CC, Schnorr TM, Daston GP, Grajewski B, Marcus M, McDiarmid M, et al. An occupational reproductive research agenda for the third millennium. Environ Health Perspect. 2003;111(4): 584-92.
  18. Rivkees SA, Crawford JD. The relationship of gonadal activity and chemotherapy-induced gonadal damage. JAMA. 1988;259(14):2123-5.
  19. Meistrich ML, Wilson G, Huhtaniemi I. Hormonal treatment after cytotoxic therapy stimulates recovery of spermatogenesis. Cancer Res. 1999;59(15): 3557-60.
  20. Jafarian A, Akhondi MA, Pezhhan N, Sadeghi MR, Zarnani AH, Salehkhou Sh, et al. Stimulatory effects of Estradiol and FSH on the restoration of spermatogenesis in azoospermic mice. J Reprod Infertil. 2009;9(4):317-25.
  21. Akbarzadeh Najar R, Akhondi MA, Parivar K, Jeddi-Tehrani M, Sadeghi MR, Djavadi E, et al. The effects of Human Chorionic Gonadotropin on germ cell maturation and testosterone secretion in neonatal mouse testis. J Reprod Infertil. 2006;7(3): 209-17.
  22. Revel A, Revel-Vilk S. Pediatric fertility preservation: is it time to offer testicular tissue cryopreservation? Mol Cell Endocrinol. 2008;282(1-2): 143-9.
  23. van Casteren NJ, van Santbrink EJ, van Inzen W, Romijn JC, Dohle GR. Use rate and assisted reproduction technologies outcome of cryopreserved semen from 629 cancer patients. Fertil Steril. 2008;90(6):2245-50.
  24. Lansac J, Royere D. Follow-up studies of children born after frozen sperm donation. Hum Reprod Update. 2001;7(1):33-7.
  25. Schlatt S, Kim SS, Gosden R. Spermatogenesis and steroidogenesis in mouse, hamster and monkey testicular tissue after cryopreservation and heterotopic grafting to castrated hosts. Reproduction. 2002;124(3):339-46.
  26. Schlatt S, Honaramooz A, Ehmcke J, Goebell PJ, Rübben H, Dhir R, et al. Limited survival of adult human testicular tissue as ectopic xenograft. Hum Reprod. 2006;21(2):384-9.
  27. Honaramooz A, Behboodi E, Blash S, Megee SO, Dobrinski I. Germ cell transplantation in goats. Mol Reprod Dev. 2003;64(4):422-8.
  28. Honaramooz A, Megee SO, Dobrinski I. Germ cell transplantation in pigs. Biol Reprod. 2002;66(1): 21-8.
  29. Honaramooz A, Li MW, Penedo MC, Meyers S, Dobrinski I. Accelerated maturation of primate testis by xenografting into mice. Biol Reprod. 2004;70(5):1500-3.
  30. Schrader M, Muller M, Straub B, Miller K. Testicular sperm extraction in azoospermic patients with gonadal germ cell tumors prior to chemotherapy--a new therapy option. Asian J Androl. 2002;4(1):9-15.
  31. Keros V, Hultenby K, Borgström B, Fridström M, Jahnukainen K, Hovatta O. Methods of cryopreservation of testicular tissue with viable spermatogonia in pre-pubertal boys undergoing gonadotoxic cancer treatment. Hum Reprod. 2007;22(5):1384-95.
  32. Wyns C, Curaba M, Martinez-Madrid B, Van Langendonckt A, François-Xavier W, Donnez J. Spermatogonial survival after cryopreservation and short-term orthotopic immature human cryptorchid testicular tissue grafting to immunodeficient mice. Hum Reprod. 2007;22(6):1603-11.
  33. Luetjens CM, Stukenborg JB, Nieschlag E, Simoni M, Wistuba J. Complete spermatogenesis in orthotopic but not in ectopic transplants of autologously grafted marmoset testicular tissue. Endocrinology. 2008;149(4):1736-47.
  34. Sofikitis N, Pappas E, Kawatani A, Baltogiannis D, Loutradis D, Kanakas N, et al. Efforts to create an artificial testis: culture systems of male germ cells under biochemical conditions resembling the seminiferous tubular biochemical environment. Hum Reprod Update. 2005;11(3):229-59.
  35. Zeng W, Avelar GF, Rathi R, Franca LR, Dobrinski I. The length of the spermatogenic cycle is conserved in porcine and ovine testis xenografts. J Androl. 2006;27(4):527-33.
  36. Zeng W, Rathi R, Pan H, Dobrinski I. Comparison of global gene expression between porcine testis tissue xenografts and porcine testis in situ. Mol Reprod Dev. 2007;74(6):674-9.
  37. Fujita K, Tsujimura A, Hirai T, Ohta H, Matsuoka Y, Miyagawa Y, et al. Effect of human leukemia cells in testicular tissues grafted into immuno-deficient mice. Int J Urol. 2008;15(8):733-8.
  38. Brinster RL, Avarbock MR. Germline transmission of donor haplotype following spermatogonial transplantation. Proc Natl Acad Sci U S A. 1994;91 (24):11303-7.
  39. Brinster RL, Zimmermann JW. Spermatogenesis following male germ-cell transplantation. Proc Natl Acad Sci U S A. 1994;91(24):11298-302.
  40. Akbarzadeh Najar R, Jeddi-Tehrani M, Sadeghi MR, Zarnani AH, Salehkhou SH, Hoseinzadeh F, et al. Spermatogonial Stem Cell Transplantation in Mice. Tehran Univ Med J. 2008;65(Suppl 3):1-10.
  41. Avarbock MR, Brinster CJ, Brinster RL. Reconstitution of spermatogenesis from frozen spermatogonial stem cells. Nat Med. 1996;2(6):693-6.
  42. Nagano M, Avarbock MR, Leonida EB, Brinster CJ, Brinster RL. Culture of mouse spermatogonial stem cells. Tissue Cell. 1998;30(4):389-97.
  43. Kanatsu-Shinohara M, Ogonuki N, Inoue K, Ogura A, Toyokuni S, Shinohara T. Restoration of fertility in infertile mice by transplantation of cryopreserved male germline stem cells. Hum Reprod. 2003;18(12):2660-7.
  44. Dobrinski I. Transplantation of germ line stem cells for the study and manipulation of spermatogenesis. Ernst Schering Res Found Workshop. 2006;(60):175-93.
  45. Hermann BP, Sukhwani M, Lin CC, Sheng Y, Tomko J, Rodriguez M, et al. Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques. Stem Cells. 2007;25(9):2330-8.
  46. Radford J. Restoration of fertility after treatment for cancer. Horm Res. 2003;59 Suppl 1:21-3.
  47. Geens M, Goossens E, De Block G, Ning L, Van Saen D, Tournaye H. Autologous spermatogonial stem cell transplantation in man: current obstacles for a future clinical application. Hum Reprod Update. 2008;14(2):121-30.
  48. Hovatta O. Cryopreservation of testicular tissue in young cancer patients. Hum Reprod Update. 2001; 7(4):378-83.
  49. Kvist K, Thorup J, Byskov AG, Hoyer PE, Mollgard K, Yding Andersen C. Cryopreservation of intact testicular tissue from boys with cryptorchidism. Hum Reprod. 2006;21(2):484-91.
  50. Yoshinaga K, Nishikawa S, Ogawa M, Hayashi S, Kunisada T, Fujimoto T, et al. Role of c-kit in mouse spermatogenesis: identification of spermatogonia as a specific site of c-kit expression and function. Development. 1991;113(2):689-99.
  51. Dym M, Kokkinaki M, He Z. Spermatogonial stem cells: mouse and human comparisons. Birth Defects Res C Embryo Today. 2009;87(1):27-34.
  52. Kubota H, Avarbock MR, Brinster RL. Spermatogonial stem cells share some, but not all, phenotypic and functional characteristics with other stem cells. Proc Natl Acad Sci U S A. 2003;100(11): 6487-92.
  53. von Schönfeldt V, Krishnamurthy H, Foppiani L, Schlatt S. Magnetic cell sorting is a fast and effective method of enriching viable spermatogonia from Djungarian hamster, mouse, and marmoset monkey testes. Biol Reprod. 1999;61(3): 582-9.
  54. Jahnukainen K, Hou M, Petersen C, Setchell B, Söder O. Intratesticular transplantation of testicular cells from leukemic rats causes transmission of leukemia. Cancer Res. 2001;61(2):706-10.
  55. Fujita K, Ohta H, Tsujimura A, Takao T, Miyagawa Y, Takada S, et al. Transplantation of spermatogonial stem cells isolated from leukemic mice restores fertility without inducing leukemia. J Clin Invest. 2005;115(7):1855-61.
  56. Geens M, Van de Velde H, De Block G, Goossens E, Van Steirteghem A, Tournaye H. The efficiency of magnetic-activated cell sorting and fluorescence-activated cell sorting in the decontamination of testicular cell suspensions in cancer patients. Hum Reprod. 2007;22(3):733-42.
  57. Dirami G, Ravindranath N, Pursel V, Dym M. Effects of stem cell factor and granulocyte macrophage-colony stimulating factor on survival of porcine type A spermatogonia cultured in KSOM. Biol Reprod. 1999;61(1):225-30.
  58. Kubota H, Avarbock MR, Brinster RL. Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells. Proc Natl Acad Sci U S A. 2004;101(47):16489-94.
  59. Jeong D, McLean DJ, Griswold MD. Long-term culture and transplantation of murine testicular germ cells. J Androl. 2003;24(5):661-9.
  60. Kanatsu-Shinohara M, Ogonuki N, Inoue K, Miki H, Ogura A, Toyokuni S, et al. Long-term proliferation in culture and germline transmission of mouse male germline stem cells. Biol Reprod. 2003;69(2):612-6.
  61. Kanatsu-Shinohara M, Miki H, Inoue K, Ogonuki N, Toyokuni S, Ogura A, et al. Long-term culture of mouse male germline stem cells under serum-or feeder-free conditions. Biol Reprod. 2005;72(4): 985-91.
  62. Sadri-Ardekani H, Mizrak SC, van Daalen SK, Korver CM, Roepers-Gajadien HL, Koruji M, et al. Propagation of human spermatogonial stem cells in vitro. JAMA. 2009;302(19):2127-34.
  63. Lim JJ, Sung SY, Kim HJ, Song SH, Hong JY, Yoon TK, et al. Long-term proliferation and characterization of human spermatogonial stem cells obtained from obstructive and non-obstructive azoospermia under exogenous feeder-free culture conditions. Cell Prolif. 2010;43(4):405-17.
  64. Robey PG. Stem cells near the century mark. J Clin Invest. 2000;105(11):1489-91.



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