The Protective Effects of Melatonin on the Histological Changes of Testis in Busulfan-Treated Adult Mice
Introduction: Antineoplastic chemotherapy is usually accompanied by fertility impairment and the aim of this study was to investigate the possible protective effects of melatonin, a pineal gland hormone with potent antioxidant activity, on busulfan-treated adult male mice.
Materials and Methods: This study was performed on 32, eight-week old adult male mice. The animals were divided into four groups consisting of a control and three experimental groups .......
Effects of MDMA (Ecstasy) on Oocyte Quality and Fertilization Rate in Mice
Introduction: Ecstasy drug abuse is relatively common among the youth undergoing psychosocial stresses. Categorized as a stimulant drug, ecstasy has nervous, cardiac and immunological side-effects. The endocrine system is not spared from the harmful effects of the drug and it could influence ovulation by exerting its effects on the hypothalamic-hypophyseal-gonadal axis. The aim of this study was to evaluate the effects of ecstasy on the quality of oocytes and on fertilization rate in mice.
Materials and Methods: Thirty female NMRI mice were divided into three groups, after checking for their estrous cycles .......
The Relationship between Serum C-reactive Protein Levels in Early Pregnancy and Preeclampsia Onset
Introduction: Preeclampsia is one of the most common medical complications during pregnancy that can be a major cause of prenatal morbidity and mortality. One of the most studied biomarkers in the prediction of preeclampsia is C-reactive protein. The objective of this study was to assess the relationship between maternal serum CRP concentrations in early pregnancy and the onset of preeclampsia during the gestational period.
Materials and Methods: In this prospective cohort study, serum CRP levels were measured in 400 pregnant women in their 20th week of gestation. They were all followed up till delivery .......
Evaluation of Thrombophilic Factors in Women with PCOS
Introduction: Polycystic ovary syndrome (PCOS) is associated with insulin-induced elevations of plasminogen activator inhibitor (PAI-1), the most potent inhibitor of fibrinolysis. Hypofibrinolysis due to increased PAI-1 levels in PCOS patients bears a high risk for miscarriage and some other pregnancy complications which are probably due to increased thrombophilic states. In this study we compared thrombophilic factors in women with PCOS with those of healthy women.
Materials and Methods: This analytical study was performed on 123 infertile women with PCOS as the case group, and 73 women non-PCOS women with male factor infertility as the control group .......
Evaluation of Serum Nitrite, Nitrate and Malondialdehyde Concentrations in Preeclampsia
Introduction: Preeclampsia is a complication of pregnancy that is associated with high blood pressure with an unknown etiology. There is much evidence that altered endothelial cell functions may play an important role in the pathogenesis of preeclampsia. The aims of this study were to determine serum levels of nitrite, nitrate and malondialdehyde (MDA) in pregnant women with and without preeclampsia.
Materials and Methods: This observational-analytical study was performed in the third trimester of pregnancy on 35 pregnant primiparas with preeclampsia and 35 women with normal blood pressure .......
Correlation between Abnormal Glucose Challenge Test and Pregnancy Outcomes
Introduction: Gestational diabetes is the most common metabolic disorder in pregnancy. Glucose Challenge Test (GCT) is done for all pregnant women during the 24th to 28th weeks of gestation. If the GCT value is more than 130 mg/dl a Glucose Tolerance Test (GTT) is asked and if GTT is impaired, gestational diabetes mellitus (GDM) is diagnosed and she will receive treatment accordingly. Some studies have illustrated that impaired GCT can cause unfavorable pregnancy outcomes .......
The Relationship between Adverse Pregnancy Outcomes and Secondary Infertility
Introduction: Although numerous studies have depicted the association between adverse pregnancy outcomes and the future fertility status, this relationship has not been clearly outlined. A positive past medical history for adverse pregnancy outcomes, such as induced abortion, ectopic pregnancy, postpartum infection, premature rupture of membranes can affects women’s fertility prospects. The main goal of this study was to determine the relationship between previous pregnancy outcomes and secondary infertility.
Materials and Methods: This retrospective case-control study was done on 182 (92 infertile and 90 pregnant women), 15 – 45 years old patients during a six-month period in 2008 – 2009 .......
Is Early Sex Reassignment in Ambiguous Genitalia Reasonable?
Introduction: Ambiguous genitalia is a medical emergency in newborns and effort is made to perform sex reassignment and reconstructive surgery as soon as possible. However, conflict between the assigned sex and later gender identity are still present in many cases. This discrepancy between sexual and gender identities leads to several complications that are the focus of the present study .......
Letter to the Editor
Dear Editor, The published article by Dr. Ai, et al. (1) on the secretion of vascular endothelial growth factor (VEGF) in a three-dimensional endometrial culture was of great surprise to me as this model had been earlier introduced by Fasciani, et al. (2) in 2003 .......
Response to the Editor
Dear Editor,
Regarding the questions raised and comments made on the paper authored by me "Secretion of Vascular Endothelial Growth Factor in a Three-Dimensional Culture of Human Endometrium; an In-Vitro Model for Endometriosis" I have provided the following response for more clarification.
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