Journal of Reproduction and Infertility

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Volume 9, Issue 3, Number 36, October-December 2008


Serum Calcium and Magnesium in Preeclamptic and Normal Pregnancies; A Comparative Study



Fatemeh Vahidrodsari
1- Department of Obstetrics and Gynecology, Ghaem Hospital, Mashad University of Medical Sciences, Mashad, Iran
2- Research Center for Women’s Health, Mashad University of Medical Sciences, Mashad, Iran

Sedigheh Ayaty Corresponding Author
1- Department of Obstetrics and Gynecology, Ghaem Hospital, Mashad University of Medical Sciences, Mashad, Iran
2- Research Center for Women’s Health, Mashad University of Medical Sciences, Mashad, Iran

Alieh Tourabizadeh
1- Department of Obs. & Gyn., Ghaem Hospital, Faculty of Medicine, Mashad University of Medical Sciences and Health Services, Mashad, Iran
2- Research Center for Women’s Health, Mashad University of Medical Sciences, Mashad, Iran

Hossein Ayat-Allahi
Department of Hematology, Ghaem Hospital, Mashad University of Medical Sciences, Mashad, Iran

Habibollah Esmaeli
Biostatistics Center, Department of Community Medicine, Ghaem Hospital, Mashad University of Medical Sciences, Mashad, Iran

Masoud Shahabian
1- Department of Obstetrics and Gynecology, Ghaem Hospital, Mashad University of Medical Sciences, Mashad, Iran
2- Cardiovascular Research Center, Mashad University of Medical Sciences, Mashad, Iran

Received: 9/29/2007 Accepted: 6/15/2008
Abstract
Introduction: Preeclampsia is a common gestational disorder which complicates 5-8% of pregnancies and it is associated with maternal, fetal and neonatal morbidity and mortality. Alterations in serum calcium (Ca) and magnesium (Mg) levels have been suggested as effective factors in causing preeclampsia. This study was conducted to compare serum calcium and magnesium levels in preeclamptic and normal pregnant women.Materials and Methods: In this case-control study, 50 preeclamptic and 50 normal pregnant women referring to Ghaem Hospital, affiliated to Mashad University of Medical Sciences, were selected during 2005. Blood samples of both groups with similar gestational ages were collected and compared for calcium and magnesium concentrations. The data were analyzed by student t-test, 2, Kolmogorov-Smirnov, Fishers exact tests and a general linear model.Results: The demographic data in the two groups, had no significant difference (P<0.01) but there was a significant difference between them in terms of smoking history (P<0.05). Serum magnesium levels in the preeclamptic women were significantly lower than those of individuals with normal pregnancy (1.920.37 mg/dl vs. 2.290.69 mg/dl), (P<0.01) while calcium levels had no significant differences (9.160.75mg/dl vs. 9.471.58 mg/dl).Conclusion: This study revealed that serum magnesium level in preeclampsia is lower than that of the normal pregnant women. This result may support the hypothesis on the role of magnesium deficiency in preeclampsia pathophysiology and suggest the usefulness of its assessment in the early diagnosis of the disorder.

Keywords: Calcium, Magnesium, Preeclampsia, Pregnancy, Prenatal care


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