TY - JOUR T1 - Evaluation of Interleukin-10 (G-1082A) Promoter Polymorphism in Preeclampsia T2 - Journal of Reproduction & Infertility JT - Journal of Reproduction & Infertility SP - 62 EP - 67 VL - 14 IS - 2 PY - 2013 SN - 2251-676X L1 - https://www.jri.ir/documents/fullpaper/en/525.pdf L2 - https://www.jri.ir/article/525 UR - https://www.jri.ir/en/currentissue.aspx?id=55 PB - Avicenna Research Institute AU - Sabnavis, Sowmya AU - Ramaiah, Aruna AU - Sunitha, Tella AU - Nallari, Pratibha AU - Jyothy, Akka AU - Venkateshwari, Ananthapur AB - Background: Preeclampsia is a pregnancy-specific syndrome that may be life-threatening, especially to the fetus. Several causes have been reported that may have a possible role in the development of the disorder. Interleukin-10 affect maternal intravascular inflammation, as well as endothelial dysfunction. The aim of this study was to investigate the association between IL-10 G-1082A polymorphism and pre-eclampsia. Methods: A total of eighty-eight pregnant women with preeclampsia and 100 women with normal pregnancy attending the Gynecological unit of Government Maternity Hospital, Petlaburz, Hyderabad, India, were considered for the study. A standard amplification refractory mutation system (ARMS) PCR was carried out for genotyping IL-10 G-1082A promoter polymorphism in all the participants. Genotypic distribution of the control and patient groups were compared with values predicted by Hardy-Weinberg equilibrium using χ2 test. Odd ratios (OR) and their respective 95% confidence intervals were used to measure the strength of association between IL-10 gene polymorphism and preeclampsia. Results: The frequencies of IL-10 G-1082A genotypes, GG, GA and AA, were 17.8%, 41.09% and 41.09% in women with preeclampsia and 25%, 28% and 47% in the controls respectively. There was no significant difference in the distribution of genotypes and alleles of IL-10 G-1082A between the two groups (Test power=0.66). Conclusion: The present study suggests that the IL-10 G-1082A gene promoter polymorphism is not a major genetic regulator in the etiology of preeclampsia. CY - Tehran, Iran KW - ARMS PCR KW - Cytokines KW - Interleukin-10 KW - Polymorphism KW - Preeclampsia LA - English