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Incidence and growth of uterine myoma after ovulation induction on 1100 infertile women in shahid Akbarabadi Hospital and Royan Institute
<p>The aim of this study was to determine the incidence and growth rate of uterine myomas in users of ovulation induction drugs. Eleven hundred in fertile women who had undagone at least 5 cycles of ovulation induction, refering to Royan Institute and Akbarabadi Hospital were selected on the basis of easy access selection method. To study presence or absence of uterine myoma, all the patients were subjected to sonograply before ovulation induction The sonography was repeated after at least 5 cycles of ovulation induction and was compared with the initial sonography. Of the 1100 patients, 54 had myoma and of the 1046 myoma–free patients, 71 (6.8%) developed myoma later and of the 54 with initial myoma, 40 (%74) showed increased growth of their myoma. This study is a beginning for studies on the effect of ovulation induction on the growth rate of uterine myomas and may be a comparison basis for the incidenee and growth rate of myomas in an age matched control group of women.</p>
میوم رحمی، ناباروری، تحریک تخمکگذاری، روشهای کمک باروری
Uterine myoma, Infertility, Ovulation induction, Assisted Reproductive Techniques
11
20
https://www.jri.ir/article/36
https://www.jri.ir/documents/fullpaper/fa/36.pdf
MahnazAshrafiInfertility team of Royan Research Center, Tehran, Iranمهناز اشرفي72
MasoumehSadeghiIran University of Medical Science, Tehran, Iranمعصومه صادقي108
ZohrehMontazeriIran University of Medical Science, Tehran, Iranزهرهمنتظري109
ShahramTavajjohiDepartment of Epidemiology and Reproductive Health Royan Institute, Tehran, Iranشهرام توجهي فيني110
en
Evaluation of factors influencing GIFT and comparison of GIFT and IVF results at infertility center of Shariati hospital during 1376-78
<p>Today there are a number of methods of Assisted Reproductive Technology. The classic method of IVF has a pregnancy rate of 11-12%. GIFT is a new method with a pregnancy rate of 25–35%. In this study 71 patients were included in GIFT cycle. In our study Pregnancy rate of GIFT was 29.6% whereas in 130 cycles of IVF the pregnancy rate was 14.6%. In this study we found that female age, the number of transfered oocytes, serum estradiol on hCG injection day and sperm characteristics were influential factors affecting the outcome of GIFT.</p>
لقاح خارج رحمی، GIFT، استرادیول، تخمک، سن
GIFT, IVF, Female age, Estradiol, Oocyte
20
27
https://www.jri.ir/article/37
https://www.jri.ir/documents/fullpaper/fa/37.pdf
AshrafAlyasinDepartment of Gynecology and Obstetrics ,Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iranاشرفآل ياسين89
MarziehAgha HossineiDepartment of Gynecology and Obstetrics ,Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iranمرضيهآقاحسيني88
AfsanehKhademiDepartment of Gynecology and Obstetrics ,Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iranافسانه خادمي 101
HojjatallahSaeidi SaeidabadyMedical Biochmistry Department, Faculty of Medicine, Tehran Medical Sciences University, Tehran, Iranحجت الله سعيدي سعيد آبادي 100
en
Comparison of quality and early postoperative complications between Laparascopy and Laparotomy in 112 women undergoing tubal ligation
<p>The aim of this study was to evaluate the quality, effective ness and the ideal method of tubal ligation with low complication, low bleeding and early recovery. In this investigation we compared the early complications and the quality of operations in two different tubul ligation techniqwes on totally 112 women who were operated in two centers in Tehran, Iran; In one group (53 women ) tubal ligation was carried out by laparascopy (with clips and cautery, whereas the other group (59 women) was operated using Pomeroy technique in laparotomy. Collection of information was done using questionare and case selection and grouping was performed randomly. The results showed that the duration of operation and hospitalization as well as the amount of bleeding were less in laparascopy group than in laparatomy group (P<0.05). Moreover, women in laparascopy group could completely retain their activity more rapidly than the other group. Hematoma and infection were only slightly higher in patients in laparatomy group (P>0.05), whereas pain occurred more aften in the laparatomy group (P<0.05). It can be concluded that complications occur less often in the laparascopy goup in compoarison with lapartony goup and tubal ligation with laparascopy can be considerd as a better and safer method.</p>
بستن لوله، لاپاراسکوپی، لاپاراتومی، کلیپس، کوتر، پومروی
Tubal Ligation, Laparascopy, Pomeroy, Laparatomy, Clips, Couterization
27
33
https://www.jri.ir/article/38
https://www.jri.ir/documents/fullpaper/fa/38.pdf
SoheilaArefiReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iranسهيلا عارفي 124
en
Concealed Consent
<p>The issue of consent is an old and controversial question in the field of medical ethics. Nowadays, informed consent is widely considered as a fundamental element in carrying out any medical treatments on a person. Yet some aspects of the issue are blurred and need to be studied more carefully. In the present, article after dealing with three concepts of Expressed Consent, Implied Consent and Concealed Consent, it will be concluded that expressed consent is the sole way to reveal and determine the consent of the person in the field of ART. The main contribution of this article is to discuss the concept of the concealed consent. It is discused that concealed consent is a fiction and thus may not be considered in medical treatments on a person.</p>
رضایت، رضایت آگاهانه، رضایت صریح، رضایت ضمنی، رضایت مکنون، اخلاق پزشکی، کرامت انسانی، قیم مآبی در پزشکی
Consent, Informed consent, Expressed consent, Implied consent, Concealed consent, Medical ethics, Paternalism, Medical paternalism
33
38
https://www.jri.ir/article/39
https://www.jri.ir/documents/fullpaper/fa/39.pdf
Seyyed MohammadSeyed FatemiFaculty Of Law, Shahid Beheshti Universiti , Tehran, Iranسيد محمدسيد فاطمي119
en
The role of acrosin in reproduction
<p>Acrosin, an endoprotease with trypsin-like substrate specificity, is localized in the acrosomal matrix as an enzymatically inactive zymogen, proacrosin, that is then converted into the active form as a consequence of the acrosome reaction. The physiological role of acrosin in fertilization has long been believed to be the limited proteolysis of the zona pellucida. Using homologous recombination, we have previously successfully produced male mice carrying a disruptive mutation in the acrosin gene and found that the mouse sperm lacking acrosin protease activity still penetrate zona pellucida and normally fertilize the egg .These Results provide evidence, that acrosin is not essential for sperm penetration of the zona pellucida. However, mouse sperm lacking acrosin showed a delay in penetration of the zona pellucida solely at the early stage after insemination .To elucidate the role of acrosin in fertilization, we have examined the involvement of acrosin in fertilization of zona pellucida after hardening and agining. We used DMSO for the hardening of zona pellucida. We observed that sperm lacking acrosin showed a reduced fertilitzation of eggs after zona pellucida hardening and aging. These data suggest the role of acrosin in combined infertility, which male and female factors are involved</p>
آکروزین، هدفگیری ژنی، واکنش آکروزومی، باروری، ناباروری
Acrosin, Gene targeting, Combined infertility, Acrosome reaction
38
44
https://www.jri.ir/article/40
https://www.jri.ir/documents/fullpaper/fa/40.pdf
KarimNayerniaReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iranكريم نيرنيا55
IbrahimAdhamInstitute of Human Genetics, University of Gothingen, Gothingen, Germanyابراهيم ادهم 127
RahmanShamsedinInstitute of Human Genetics, University of Gothingen, Gothingen, Germanyرحمانشمس الدين133
WolfgangEngelInstitute of Human Genetics, University of Gothingen, Gothingen, Germanyولفگانگ انگل 136
en
Accuracy of ultrasonographic parameters in detection of growth restricted foetuses
<p>The main objective of this study was to review the diagnostic accuracy of different single ultrasonographic parameters in predicting intrauterine growth restricted foetuses as defined by Ponderal Index at birth. The study sample composed of two sets of data from Iran and Australia. The Iranian samples consisted of 296 Iranian women. All the study women received prenatal care and delivered at Fatemieh Hospital in Shahrood, Iran. The data from 200 Australian fetuses were obtained from the ultrasound section at the Wollongong Hospital in Australia. Ultrasonographic measurements of Biparietal diameter (BPD), femur length (FL), head circumference (HC), abdominal circumference (AC), amniotic fluid index (AFI) and Doppler from umbilical arteries (S/D ratio) were obtained. Only those pregnancies were included in which the estimated date of delivery (EDD) by LMP (last menstrual period) agreed within 14 days with the estimated date of delivery determined by the initial ultrasound examination. Sensitivity (SE), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV) were calculated for single proposed ultrasound parameters in the both Iranian and Australian samples. When different variables are compared, with a cut off point at or below the 10th percentile, AC and HC had the highest sensitivities in the Australian sample while AC was the most sensitive parameter for IUGR detection in the Iranian sample. BPD has a reasonably high sensitivity at this threshold. The AFI ratio had the lowest sensitivity in predicting IUGR in the Australian sample. Positive predictive values were low in all of the parameters in both the Iranian and Australian samples. Our results indicate that reduced AC was the best single parameter in discriminating between IUGR and non-IUGR fetuses with the highest sensitivity among the proposed parameters in the both Iranian and Australian sample. However the positive predictive value of this parameter is low. This means that a high number of false positive cases is detected using each parameter which reduces the usefulness of identification. Other ultrasound obstetrical parameters may also have a reasonable level of sensitivity, however the positive predictive value of all parameters is low. On the whole our results show that although the examined ultrasonographic criteria may detect a group of fetuses that need close antepartum surveillance, none of these parameters is appropriate enough to be used in isolation in clinical practice. Using single ultrasound parameters does not have high sensitivity and positive predictive values in detection of fetal growth restriction. This limits both accuracy and utility of these tests in the detection of IUGR fetuses.</p>
IUGR، رشد جنین، پارامترهای اولتراسونوگرافیک، بارداری
Pregnancy, Ultrasonographic parameters, IUGR, Fetus growth
4
11
https://www.jri.ir/article/35
https://www.jri.ir/documents/fullpaper/fa/35.pdf
ParvinNiknafsObstetrics ultrasound, Shahrood University of Medical Sciences., Shahrood, Iranپروين نيك نفس 106
JohnSibbaldMidwifery and Physiology, Wollongong University, Wollongong, Australiaجان سيبالد 107
en
Production and characterization of a murine monoclonal antibody recognizing a conformational epitope on hCG
<p>Human chorionic gonadotropin hormone (hCG) belongs to glycoprotein hormones family. Other members of this family include follicle stimulating hormone (FSH), luteinizing hormone (LH) and thyroid stimulating hormone (TSH). All these hormones consist of a common alfa and a distinct beta subunit. There is a strong similarity between the members of these hormones. Therefore, detection and quantitative measurment of these hormones require production of monoclonal antibodies specific for non-overlapping epitopes on the beta chain or a conformational epitope specific for each hormone. In this study a murine monoclonal antibody against the hCG dimer molecule was produced by hybridoma technology. The specificity of the antibody was assessed by ELISA and Immunoblotting using a panel of highly purified and recombinant forms of glycoprotein hormones including: native hCG and hLH, recombinant hCG, hCG, hCG, hCG carboxyl terminal peptide covering amino acid residues 109-145 (hCG-CTP), recombinant TSH and native FSH, as well as urine proteins (UP). It was found that the monoclonal antibody reacted with, dimer recombinant and urine purified hCG and hLH, but not with the reduced form of the hormone, nor with recombinant hCG, hCG, TSH, native FSH and UP. Using hCG-CTP fragment with different concentrations to monitor inhibition of hormone – monoclonal antibody interactions, no interference was observed. This implies that the epitope recognized by the monoclonal antibody is different from that presented by hCG–CTP. These results suggest that the monoclonal antibody recognizes a conformational epitope located at the dimer form of hCG molecule and closely associated with the beta subunit of the hormone.</p>
هورمونهای گلیکوپروتئینی، هورمون گنادوتروپین جفتی انسان، آنتی بادی منوکلونال، تعیین نقشه جایگاه های آنتی ژنی
Glycoprotein hormones, HCG, Monoclonal antibody, Epitope mapping
44
55
https://www.jri.ir/article/41
https://www.jri.ir/documents/fullpaper/fa/41.pdf
Ali AkbarSabooryaraghiDepartment of Biochemistry, Medical Faculty, Tarbiat Modarres University, Tehran, Iranعلي اكبرصبور يراقي 137
RoyaGhodsDepartment of Immunology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iranرويا قدس 138
FazelShokriDepartment of Immunology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iranفاضل شكري 140
en
Serum and follicular fluid IL-6 and sex steroid hormone levels and their correlation of undergoing IVF-ET with endometriosis and pregnancy rate in women
<p>Cytokines Not only do regulate physiological processes, but also play important roles in immunopathological reactions. The aim of this study was to evaluate the correlation between IL-6 and sex hormone levels with endometriosis and pregnancy rate at the time of oocyte retrieval. In infertile women undergoing IVF-ET Eighty patients received ovulation induction drugs and underwent IVF-ET. IL-6 levels in serum and follicular fluid (FF) were measured by ELISA and FSH, estradiol and progesterone by RIA. In 36 out of 80 patients embryos were transferred and pregnancy rate were evaluated after two weeks. The result showed no significant correlation between serum and FF levels of estradiol, progesterone and FSH with pregnancy rate in IVF patients. Similar levels of IL-6 in serum and FF of pregnant and non pregnant patients after embryo transfer were observed (P>0.05). However there was a significant correlation between FF levels of IL-6 in pregnant and non pregnant endometriosis patients (P<0.05). These results indicate that increase of FF levels of IL-6 may be accompanied by pregnancy rate reduction in endometriosis patients.</p>
اینترلوکین-6، مایع فولیکولی، هورمون های جنسی، اندومتریوز، لقاح خارج رحمی، انتقال جنین، بارداری
IL-6, Follicular fluid, Sex hormone, Endometriosis, Pregnancy rate, IVF-ET
55
63
https://www.jri.ir/article/42
https://www.jri.ir/documents/fullpaper/fa/42.pdf
MohammadNouriBiochemistry Department, Tabriz Univarsity of Medical Sciences, Tabriz, Iranمحمد نوري 143
MaerefatGhaffariReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iranمعرفتغفاري نوین71
AliSalmasiInfertility Center, Kiel University, Kiel, Germanyعلي سلماسي144
AliehGhasemzadehDepartment of Obstet . and Gynecol . of Tabriz University of Medical Science, Tabriz, Iranعاليهقاسم زاده166