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23926527
Introduction of Sensitive and Specific Biomarkers Can Improve Infertility Treatment Success Rates
069
71
https://www.jri.ir/article/574
https://www.jri.ir/documents/fullpaper/en/574.pdf
Mohammad RezaSadeghiEditor-in-chief, Tehran, Iran محمدرضاصادقی77
en
23926528
Investigating Marital Relationship in Infertility: A Systematic Review of Quantitative Studies
Background: Infertility is a complex issue that affects individuals and groups, and also it has serious implications for the mental and social well-being of those involved. The aim of this review was to assess marital relationship in the context of infertility, using data from infertile individuals or both couples.
Methods: A literature search was undertaken using multiple databases (Medline, PsycInfo and Scopus) to identify and synthesize all relevant literature published from 1990 to 2011. All studies in the systematic review were confirmed using specific inclusion criteria; the methodological quality of these studies were examined according to a checklist.
Results: Of the potential 794 articles, 18 studies were included in the final analysis, of which 6 were graded as high quality and 12 as moderate. The results indicated male factor infertility did not have a negative marital impact. In addition, infertile male participants expressed higher marital satisfaction than their wives. Infertile females had significantly less stable marital relationship compared to fertile females, which was associated with their socio-demographics and treatment experience. For infertile couples, the infertile subjects or their partners’ marital relationship was affected by either member’s infertility, experience specifically coping strategies. Moreover other factors such as sexual satisfaction, age of the infertile couples, education level, and congruency of couples’ perceptions of infertility were associated with the quality of martial relationship.
Conclusion: Although the review can provide an outline of marital relationship in infertility, future studies should focus on the perspective from both infertile couple, across a range of different infertility types, including extended sample sizes and longitudinal study designs. In addition, more consideration should be given to qualitative study.
Female, Infertile couples, Infertility, Male, Marital relationship
071
81
https://www.jri.ir/article/487
https://www.jri.ir/documents/fullpaper/en/487.pdf
PengTaoDepartment of Sexology, School of Public Health, Curtin University, Perth, Perth, AustraliaPengTaopengtao1@china.com1021
RosemaryCoatesDepartment of Sexology, School of Public Health, Curtin University, Perth, Perth, AustraliaRosemaryCoates1022
BruceMaycockCurtin Health Innovation Research Institute, Curtin University, Perth, AustraliaBruce Maycock1023
en
23926529
Lipid Peroxidation and Nitric Oxide Levels in Male Smokers' Spermatozoa and their Relation with Sperm Motility
Background: Nitric oxide (NO) is synthesized from L-arginine by a family of enzymes known as nitric oxide synthases. Low concentrations of NO is essential in biology and physiology of spermatozoa, but high amounts of NO is toxic and has negative effects on sperm functions. Moreover, sperm membrane contains high concentrations of polyunsaturated fatty acids that are highly susceptible to oxidative damage that interferes with fertilization ability. Therefore, we investigated the correlation between levels of sperm malondialdehyde (MDA) and NO with sperm motility in male smokers.
Methods: Semen samples were collected from normozoospermic smoker (n=64) and nonsmoker (n=83) men. The content of sperm lipid peroxidation was determined by measuring malondialdehyde (MDA). The sperm NO were also measured using Griess reagent. Data was analyzed by SPSS, (version 15.0), using independent t-test and Pearson analysis.
Results: The mean MDA and NO concentrations in the sperm of normozoospermic male smokers were significantly higher than the control group or normozoospermic nonsmokers, (p <0.001). A significant negative relationship was noted between sperm motility and sperm MDA levels (r=0.32- p=0.01); and sperm motility and sperm NO concentration (for nitrite, r=0.34, p=0.006 and for nitrate, r=-0.38, p=0.002).
Conclusion: It was concluded that the increase in MDA and NO production in sperm can influence sperm motility in normozoospermic smokers. Therefore, it seems that cigarette smoking may affect the fertility of male smokers via increasing the amount of sperm MDA/lipid peroxidation and NO concentrations.
Cigarette smoking, Human sperm, Lipid peroxidation, Nitric oxide, Smoker men
081
88
https://www.jri.ir/article/496
https://www.jri.ir/documents/fullpaper/en/496.pdf
Mohammad AliGhaffariDepartment of Biochemistry, School of Medicine, Ahwaz Jundishapur University of Medical Sciences, Ahvaz, IranMohammad AliGhaffarighaffarima@yahoo.com1030
MoradRostamiDepartment of Biochemistry, School of Medicine, Ahwaz Jundishapur University of Medical Sciences, Ahvaz, Iranمرادرستمي815
en
23926530
Combination of Thrombophilic Gene Polymorphisms as a Cause of Increased the Risk of Recurrent Pregnancy Loss
Background: Recurrent pregnancy loss is (RPL) a heterogeneous condition. While the role of acquired thrombophilia has been accepted as an etiology for RPL, the contribution of specific inherited thrombophilic gene polymorphisms to the disorder has been remained controversial.
Methods: One hundred women with a history of two or more consecutive abortions and 100 women with at least two live births and no miscarriages were included in the study and evaluated for the presence of 11 thrombophilic gene polymorphisms (Factor V LEIDEN, Factor V 4070 A/G, Factor V 5279 A/G, Factor XIII 103 G/T, Factor XIII 614 A/T, Factor XIII 1694 C/T, PAI-1 -675 4G/5G, ITGB3 1565 T/C, β-Fibrinogen -455G/A, MTHFR 677 C/T, MTHFR 1298 A/C) using PCR-RFLP technique. The data were statistically analyzed using Mann-Whitney test and logistic regression model.
Results: There was no relation between factor XIII 103G/T gene polymorphism with increased risk of RPL. However, the other 10 gene polymorphisms were found to be associated with increased/decreased risk of RPL. Multiple logistic regression model for analyzing the simultaneous effects of these polymorphisms on the risk of RPL showed that six of these 11 polymorphisms (Factor V 1691G/A, Factor V 5279A/G, Factor XIII 614A/T, β-Fibrinogen -455G/A, ITGB3 1565T/C, and MTHFR 1298A/ C) were associated with RPL.
Conclusion: It is possible to calculate the risk of abortion in a patient with RPL by determining only six of the 10 polymorphisms that are individually associated with RPL.
PCR-RFLP, Recurrent Pregnancy Loss, Thrombophilic gene
089
95
https://www.jri.ir/article/494
https://www.jri.ir/documents/fullpaper/en/494.pdf
RahelehTorabiDepartment of Medical Genetics, National Institute for Genetic Engineering and Biotechnology (NIGEB), Tehran, Iranراحلهترابی743
SaeedZareiMonoclonal Antibody Research Center, Avicenna Research Institute (ACECR), Tehran, Iranسعیدزارعی683
HojjatZeraatiDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iranحجتزراعتی481
Amir HassanZarnaniImmunology Research Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iranامیرحسنزرنانی241
Mohammad MehdiAkhondiReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iranمحمدمهدیآخوندی21
RezaHadaviMonoclonal Antibody Research Center, Avicenna Research Institute (ACECR), Tehran, Iranرضاهادوی769
ElhamSavadi-ShirazReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran746
MahmoodJeddi-TehraniMonoclonal Antibody Research Center, Avicenna Research Institute (ACECR), Tehran, Iranمحمود جدیتهرانیmahjed@yahoo.com54
en
23926531
Body Mass Index (BMI) and Glucose Intolerance during Pregnancy in White European Women
Background: The risk of gestational diabetes mellitus (GDM) in accordance to Body Mass Index (BMI) is often based on studies where the calculation of BMI is frequently self-reported and is usually unreliable. We evaluated the risk of an abnormal oral glucose tolerance test (OGTT) in a population where BMI was measured and selective screening for GDM was practiced.
Methods: We carried out a prospective observational study where 1935 white European women with a singleton pregnancy were recruited. In the first trimester maternal height and weight were measured digitally. Statistical analysis was performed using SPSS version 15.0. BMI centiles were calculated from the study population. A Chi-square test was used to test the differences in categorical variables between the groups. A p-value <0.05 was considered significant.
Results: In 1935 women, 547 OGTTs were performed and 70 of these were abnormal. The prevalence of an abnormal OGTT was higher in women with Class 2 and 3 obesity compared to women with Class 1 obesity (23.3% vs. 10.1%, respectively; p= 0.008). The frequency of an abnormal OGTT was higher in women with a BMI ≥90th centile (≥33.1 kg/m2) compared to women with a BMI between the 80th and 90th centiles (≥29.3 and <33.1 kg/m2), (21.5% vs 8.1% respectively; p=0.005).
Conclusion: When BMI is measured, we recommend to increase the cut-off point for selective screening of GDM to ≥33.0 kg/m2. This may decrease unnecessary obstetric interventions and healthcare costs.
Body Mass Index, Gestational Diabetes Mellitus, Glucose intolerance, Maternal obesity
095
100
https://www.jri.ir/article/495
https://www.jri.ir/documents/fullpaper/en/495.pdf
NadineFarahUniversity College Dublin Centre for Human Reproduction, Coombe Women and Infants University Hospital, Dublin, IrelandNadineFarahdrnfarah@gmail.com1024
AoifeMcGoldrickUniversity College Dublin Centre for Human Reproduction, Coombe Women and Infants University Hospital, Dublin, IrelandAoifeMcGoldrick1025
ChroFattahUniversity College Dublin Centre for Human Reproduction, Coombe Women and Infants University Hospital, Dublin, IrelandChroFattah1026
NorahO’ConnorUniversity College Dublin Centre for Human Reproduction, Coombe Women and Infants University Hospital, Dublin, IrelandNorahO’Connor1027
MaireadM KennellyUniversity College Dublin Centre for Human Reproduction, Coombe Women and Infants University Hospital, Dublin, IrelandMaireadM Kennelly1028
MichaelTurnerUniversity College Dublin Centre for Human Reproduction, Coombe Women and Infants University Hospital, Dublin, Ireland1029
en
23926532
Adolescent Males and Young Females in Tehran: Differing Perspectives, Behaviors and Needs for Reproductive Health and Implications for Gender Sensitive Interventions
Background: Despite cultural and religious prohibitions against premarital heterosexual relationships and intimacy, some recent evidence suggests some rise in premarital heterosexual interactions and relationships among young people. On the other hand, although HIV in Iran is a concentrated epidemic and mainly reported among high risk groups such as injecting drug users (IDUs), but there are evidences that the mode of transmission is shifting towards sexual contacts. This trend has caused concern among health policy makers in terms of prevention of STDs and HIV/AIDS particularly, among young people. This paper was prepared with the aim of highlighting how gender contributes to variation in reproductive health needs and conduct of young people in Iran.
Method: This paper is based on a secondary analysis and compares comparable reproductive beliefs and conducts of women and men based on the data of two surveys conducted in Tehran in 2002 and 2005. A survey among 1385 adolescent males and another survey among 1743 female undergraduate students in four multidisciplinary universities in Tehran. Both surveys used anonymous self-administered questionnaires. To make the two samples comparable, the data of unmarried female university undergraduate students who resided in Tehran were merged with the data of adolescent male students who intended to pursue higher education. Common variables of the two surveys were identified, homogenized, merged and analysed.
Results: Reproductive health knowledge among male adolescents was poor compared to that of their female peers. Although premarital friendships were moderately acceptable from view points of both males and females, the majority were against premarital sex, particularly among female participants. There were evidences of gender-based double standards in perceptions of premarital sexuality among both males and females; particularly, it was stronger among males than females. Male adolescents reported earlier and greater experiences of premarital hetero-sexual intimacy and sexual contact than females. Multiple partners were also more common among males than females. Females had a tendency to regret first sexual contact more than males, which reflects that first sex is more likely to be unplanned and unwanted among females compared to males.
Conclusion: Significant gender–based double standards prevailed current sexual attitudes and conduct of young people in Iran. Gender norms which encourage unmarried men to practice premarital sex lead to an earlier transition of men to sexual relations and multiple sexual partners. Due to poor knowledge and various misconceptions about sexual health and lack of consistent contraceptive and condom use among adolescents and young people in Iran, both young men and women are susceptible to sexual and reproductive health hazards such as sexually transmitted infections (STIs), HIV/AIDS, pregnancy and unsafe abortion. Changing gender norms associated with sexuality may lead to promotion of safer sexual behaviors particularly among young people. Current reproductive health and HIV prevention programs should take into account gender-based double standards among young people and their unmet reproductive health needs.
Adolescent, Attitude, Gender, Reproductive behavior, Sexual behavior, Young people
101
111
https://www.jri.ir/article/498
https://www.jri.ir/documents/fullpaper/en/498.pdf
FaridehKhalajabadi FarahaniMidwifery and Reproductive Health Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iranfaridehfarahani@yahoo.com147
IqbalShahDepartment of Reproductive Health and Research, World Health Organisation, Geneva, SwitzerlandIqbalShah1037
JohnClelandCentre for Population Studies, London School of Hygiene and Tropical Medicine, London, EnglandJohnCleland991
Mohammad RezaMohammadiDepartment of Psychiatry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iranمحمدرضامحمدي146
en
23926533
Psychological Distress in Women with Polycystic Ovary Syndrome from Imam Khomeini Hospital, Tehran
<p>Background: Polycystic ovary syndrome (PCOS) is a complex, multifaceted, heterogeneous disorder, affecting 4%-18% of reproductive-aged women and it is associated with reproductive, metabolic and psychological dysfunctions. PCOS affects quality of life and can worsen anxiety and depression either due to the features of PCOS or due to the diagnosis of a chronic disease. Methods: In this descriptive-analytical study, 81 patients with PCOS were recruited from Vali-e-Asr Reproductive Health Research Center. A questionnaire with items related to pieces of information about stress was used for data collection. Stress symptoms were assessed using the Understanding Yourself questionnaire. Statistical analyses were performed using SPSS Ver. 13.0 (SPSS Inc., Chicago, ILL, USA). The data are presented as mean±SD or as frequency with percentages. A p-value less than 0.05 was considered as statistically significant. Results: The descriptive results showed that 8 (9.9%) participants did not have any signs of stress, 32 (39.5%) had neurotic stress, 29 (35.8%) had high and 12 (14.8%) had extremely high levels of stress. The odds of high levels of anxiety in women with hirsutism was 3.1 (95% CI, 1.00-9.59). The odds of high levels of obsession in overweight patients was 3.2 (95% CI, 1.12-9.234). The odds of high levels of worries in patients with touchy personality was 3.4 (95% CI, 1.10-11.19) obsession score. Conclusion: The present study showed that clinical signs of PCOS were most closely associated with psychological distress which has important implications in the diagnosis and treatment of disorders.</p>
Anxiety, Hysteria, Obsession, Polycystic ovary syndrome, Worries
111
116
https://www.jri.ir/article/501
https://www.jri.ir/documents/fullpaper/en/501.pdf
FaridehZafari ZangenehVali-e- Asar Reproductive Health Research Center,Tehran Medical Sciences University, Tehran, Iranفريدهظفري زنگنهZangeneh14@gmail.com843
MinaJafarabadiVali-e- Asar Reproductive Health Research Center,Tehran Medical Sciences University, Tehran, Iranمينا جعفرآبادي754
Mohammad MehdiNaghizadehDepartment of Community Medicine, Faculty of Medicine, Fasa University of Medical Sciences, Fasa, Iranمحمدمهدینقی زاده731
NasrinAbedi-NiaVali-e- Asar Reproductive Health Research Center,Tehran Medical Sciences University, Tehran, Iranنسرینعابدی نیا730
FedyehHaghollahiVali-e- Asar Reproductive Health Research Center,Tehran Medical Sciences University, Tehran, Iranفدیهحقاللهی508
en
23926534
Postpartum Peripheral Symmetrical Gangrene: A Case Report
Background: Symmetrical peripheral gangrene is usually associated with underlying medical problems and it is seldom seen in pregnancy. Sepsis though common in a setting of delivery by unskilled midwife is rarely accompanied by symmetrical gangrene.
Case Presentation: We report a case of symmetrical peripheral gangrene which occurred in the winter, triggered possibly by sepsis and a single dose of ergot. A high index of suspicion, early diagnosis and intervention with appropriate measures will result in favorable outcome in such cases.
Conclusion: Although postpartum period is of high risk for sepsis and use of ergot alkaloids is common in labor but occurrence of peripheral symmetrical gangrene is rare. A high index of suspicion for the diagnosis and timely intervention will prevent irreparable damage and loss of limb.
Ergot, Peripheral symmetrical gangrene, Postpartum
117
120
https://www.jri.ir/article/502
https://www.jri.ir/documents/fullpaper/en/502.pdf
LipiSharmaDepartment of Obstetrics and Gynecology, University College of Medical Sciences and Associated Guru Teg Bahadur Hospital, Shadara, IndiaLipiSharmawww.lip.sharma14@gmail.com1006
SumitaMehtaDepartment of Obstetrics and Gynecology, University College of Medical Sciences and Associated Guru Teg Bahadur Hospital, Shadara, IndiaSumitaMehta1007
ShaliniRajaramDepartment of Obstetrics and Gynecology, University College of Medical Sciences and Associated Guru Teg Bahadur Hospital, Shadara, IndiaShaliniRajaram1008
RachnaAgarwalDepartment of Obstetrics and Gynecology, University College of Medical Sciences and Associated Guru Teg Bahadur Hospital, Shadara, IndiaRachnaAgarwal959
SanjayGuptaDepartment of Surgery, University College of Medical Sciences and Associated Guru Teg Bahadur Hospital, Shadara, IndiaSanjayGupta1010
NeerjaGoelDepartment of Obstetrics and Gynecology, University College of Medical Sciences and Associated Guru Teg Bahadur Hospital, Shadara, IndiaNeerjaGoel1011