en
1726-7536
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2015
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26962479
Male Sexual Dysfunction, Leptin, Pituitary and Gonadal Hormones in Nigerian Males with Metabolic Syndrome and Type 2 Diabetes Mellitus
<p>Background: Pituitary and gonadal dysfunctions resulting from increased adiposity leading to disturbances of sexual and reproductive functions have been reported in males with metabolic syndrome (MS) and type 2 diabetes mellitus (DM2). The aim of this study was to evaluate sexual dysfunction, leptin, and reproductive hormones in Nigerian males with MS and DM2.<br />
Methods: Participants were 104 men (34 males with DM2, 17 men with MS and 53 men with normal body mass index (18.5-24.9 <em>Kg/m</em><sup>2</sup>) without MS (controls)). The International Diabetes Federation (2005) criteria were used for MS diagnosis. Reproductive history, anthropometry, blood pressure (BP) and 10 <em>ml</em> fasting blood samples were obtained by standard methods. Fasting plasma glucose, total cholesterol, triglycerides and high density lipoprotein cholesterol were determined by enzymatic methods while low density lipoprotein cholesterol was calculated. Leptin, follicle stimulating hormone (FSH), luteinising hormone (LH), prolactin, testosterone and oestrogen were determined by enzyme immunoassay (leptin by Diagnostic Automation, Inc.; others by Immunometrics (UK) Ltd.) while oestrogen-testosterone ratio was calculated. Data analyzed using ANOVA, Chi square and multiple regression were statistically significant at p<0.05.<br />
Results: Testosterone was significantly lower in MS than controls while oestradiol and ETR were significantly higher in MS compared with controls and DM2 group (p<0.05). ETR significantly predicted testosterone in all groups (p<0.05). Significantly lower libido was observed in men in MS than controls and DM2 groups (p<0.05).<br />
Conclusion: Sexual and reproductive dysfunction may be related to increased conversion of testosterone to oestrogen in increased adipose mass in men with metabolic syndrome and type 2 diabetes mellitus.</p>
Cardiovasculer disease, Leptin, Lipids, Metabolic syndrome, Pituitary hormones, Sex hormone, Sexual dysfunction, Type 2 diabetes mellitus
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https://www.jri.ir/article/662
https://www.jri.ir/documents/fullpaper/en/662.pdf
Unyime AniekponFabianDepartment of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria1547
Mabel AyebatonyoCharles-DaviesDepartment of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeriamcharlesdavies@yahoo.com1548
Adesoji AdedipeFasamadeDepartment of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria1549
John AyodeleOlaniyiDepartment of Haematology, College of Medicine, University of Ibadan, Ibadan, Nigeria1550
Oyediran EmmanuelOyewoleDepartment of Health Promotion and Education, College of Medicine, University of Ibadan, Ibadan, Nigeria1551
Mayowa OjoOwolabiDepartment of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria1552
Jane RoliAdebusuyiMedical Social Services Department, University College Hospital, Ibadan, Nigeria1553
OlufunkeHassanMedical Social Services Department, University College Hospital, Ibadan, Nigeria1554
Babatunde MohammadAjoboDietetics Department, University College Hospital, Ibadan, Nigeria1555
Maria OnomhaguanEbesununDepartment of Chemical Pathology, College of Health Sciences, Olabisi Onabanjo University, Ago Iwoye, Nigeria1556
KehindeAdigunGeneral Out Patient Unit, University College Hospital, Ibadan, Nigeria1557
Kehinde SolaAkiladeDepartment of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria1558
Oltubosun GaniyuArinolaDepartment of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria1559
Emmanuel Oluyemi AgbedanaDepartment of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria1560