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1726-7536
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gregorian
2016
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27141460
Endometriosis Classification-The Quest for the Holy Grail?
067
68
https://www.jri.ir/article/683
https://www.jri.ir/documents/fullpaper/en/683.pdf
ShaheenKhazaliCentre for Endometriosis and Minimally Invasive Gynaecology (CEMIG), Ashford and St. Peter’s Hospitals NHS Foundation Trust, Chertsey, United Kingdoms.khazali@me.com1624
en
27141461
Models predicting success of infertility treatment: A systematic review
<p>Background: Infertile couples are faced with problems that affect their marital life. Infertility treatment is expensive and time consuming and occasionally isn’t simply possible. Prediction models for infertility treatment have been proposed and prediction of treatment success is a new field in infertility treatment. Because prediction of treatment success is a new need for infertile couples, this paper reviewed previous studies for catching a general concept in applicability of the models.<br />
Methods: This study was conducted as a systematic review at Avicenna Research Institute in 2015. Six data bases were searched based on WHO definitions and MESH key words. Papers about prediction models in infertility were evaluated.<br />
Results: Eighty one papers were eligible for the study. Papers covered years after 1986 and studies were designed retrospectively and prospectively. IVF prediction models have more shares in papers. Most common predictors were age, duration of infertility, ovarian and tubal problems.<br />
Conclusion: Prediction model can be clinically applied if the model can be statistically evaluated and has a good validation for treatment success. To achieve better results, the physician and the couples’ needs estimation for treatment success rate were based on history, the examination and clinical tests. Models must be checked for theoretical approach and appropriate validation. The privileges for applying the prediction models are the decrease in the cost and time, avoiding painful treatment of patients, assessment of treatment approach for physicians and decision making for health managers. The selection of the approach for designing and using these models is inevitable.</p>
ART, Infertility treatment, Prediction model, Treatment success
068
82
https://www.jri.ir/article/678
https://www.jri.ir/documents/fullpaper/en/678.pdf
AlirezaZarinaraReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran1604
HojjatZeraatiDepartment of Epidemiology and Biostatistics, Tehran University of Medical Sciences, TUMS, Tehran, Iranحجتزراعتی481
KooroshKamaliReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran1427
KazemMohammadDepartment of Epidemiology and Biostatistics, Tehran University of Medical Sciences, TUMS, Tehran, Iranکاظممحمد313
ParisaShahnazariReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran1605
Mohammad MehdiAkhondiReproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iranمحمدمهدیآخوندیakhondi@avicenna.ac.ir21
en
27141462
The Effects of Imatinib Mesylate on Cellular Viability, Platelet Derived Growth Factor and Stem Cell Factor in Mouse Testicular Normal Leydig Cells
<p>Background: Growth factors play an essential role in the development of tumor and normal cells like testicular leydig cells. Treatment of cancer with anti-cancer agents like imatinib mesylate may interfere with normal leydig cell activity, growth and fertility through failure in growth factors’ production or their signaling pathways. The purpose of the study was to determine cellular viability and the levels of, platelet derived growth factor (PDGF) and stem cell factor (SCF) in normal mouse leydig cells exposed to imatinib, and addressing the effect of imatinib on fertility potential.<br />
Methods: The mouse TM3 leydig cells were treated with 0 (control), 2.5, 5, 10 and 20<em> μM</em> imatinib for 2, 4 and 6 days. Each experiment was repeated three times (15 experiments in each day).The cellular viability and growth factors levels were assessed by MTT and ELISA methods, respectively. For statistical analysis, one-way ANOVA with Tukey's post hoc and Kruskal-Wallis test were performed. A p-value less than 0.05 was considered statistically significant.<br />
Results: With increasing drug concentration, cellular viability decreased significantly (p<0.05) and in contrast, PDGF levels increased (p<0.05). Different imatinib concentrations had no significant effect on SCF level. Increasing the duration of treatment from 2 to 6 days had no obvious effect on cellular viability, PDGF and SCF levels.<br />
Conclusion: Imatinib may reduce fertility potential especially at higher concentrations in patients treated with this drug by decreasing cellular viability. The effect of imatinib on leydig cells is associated with PDGF stimulation. Of course future studies can be helpful in exploring the long term effects of this drug.</p>
Cellular viability, Growth factors, Imatinib mesylate, Leydig cell, Platelet derived growth factor, Stem cell factor
082
88
https://www.jri.ir/article/658
https://www.jri.ir/documents/fullpaper/en/658.pdf
FatemehKheradmandDepartment of Biochemistry, Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran1529
Seyyed Mohammad RezaHashemniaDepartment of Biochemistry, Urmia University of Medical Sciences, Urmia, Iran1530
NasimValizadehHematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran1531
ShivaRoshan-MilaniDepartment of Physiology, Cellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, IranShivamilani@umsu.ac.ir1532
en
27141463
Effects of Ghrelin on Sexual Behavior and Luteinizing Hormone Beta-subunit Gene Expression in Male Rats
<p>Background: The hormones of hypothalamo-pituitary-gonadal (HPG) axis have facilitative effects on reproductive behavior in mammals. Ghrelin as a starvation hormone has an inhibitory effect on HPG axis’ function. Hence, it is postulated that ghrelin may reduce the sexual behavior through inhibiting of HPG axis. The aim of this study was to examine the effects of ghrelin and its antagonist, [D-Lys<sup>3</sup>]-GHRP-6, on sexual behavior and LH beta-subunit gene expression in male rats.<br />
Methods: In this experimental study, 128 male Wistar rats were divided into two groups. Each group was further subdivided into eight subgroups (n=8 rats/subgroup) including the animals that received saline, ghrelin (2, 4 or 8 <em>nmol</em>), [D-Lys<sup>3</sup>]-GHRP-6 (5 or 10 <em>nmol</em>) or co-administration of ghrelin (4<em> nmol</em>) and [D-Lys<sup>3</sup>]-GHRP-6 (5 or 10 <em>nmol</em>) through the stereotaxically implanted cannula into the third cerebral ventricle. The sexual behavior of male rats encountering with females and the hypophyseal LH beta-subunit gene expression were evaluated at two different groups. Data were analyzed by ANOVA and p<0.05 was considered statistically significant.<br />
Results: Ghrelin injection (4 and 8 <em>nmol</em>) significantly (p<0.01) increased the latencies to the first mount, intromission and ejaculation as well as the post-ejaculatory interval. Also, 4 and 8 <em>nmol</em> ghrelin significantly (p<0.05) increased the number of mount and decreased the number of ejaculation. In co-administrated groups, [D-Lys<sup>3</sup>]-GHRP-6 antagonized the effects of ghrelin. Ghrelin injection (4 and 8 <em>nmol</em>) reduced the LH beta-subunit gene expression while pretreatment with [D-Lys<sup>3</sup>]-GHRP-6 improved the gene expression.<br />
Conclusion: Ghrelin decreased the sexual behavior and LH beta-subunit gene expression in male rats, whereas [D-Lys<sup>3</sup>]-GHRP-6 antagonizes these effects.</p>
[D-Lys3]-GHRP-6, Ghrelin, Luteinizing Hormone (LH), Male rat, Sexual behavior
088
97
https://www.jri.ir/article/642
https://www.jri.ir/documents/fullpaper/en/642.pdf
Farrin Babaei-BalderlouDepartment of Animal Sciences, Faculty of Biological Sciences, Shahid Beheshti University, Tehran, Iran1471
HomayounKhazaliDepartment of Animal Sciences, Faculty of Biological Sciences, Shahid Beheshti University, Tehran, Iranfarrin_babaei@yahoo.com1472
en
27141464
A Comparison of the Effects of Transdermal Estradiol and Estradiol Valerate on Endometrial Receptivity in Frozen-thawed Embryo Transfer Cycles: A Randomized Clinical Trial
<p>Background: The purpose of this study was to determine the optimal endometrial preparation protocol by comparing the clinical outcome of two methods of endometrial preparation in frozen-thawed embryo transfer (FET) cycles, including that is, oral estradiol and 17ß-estradiol transdermal patch.<br />
Methods: In this randomized controlled trial, women underwent either conventional IVF or intracytoplasmic sperm injection (ICSI) who had at least two top-quality embryos appropriate for cryopreservation and frozen embryos from previous cycles. In the study group (n=45), 17-B estradiol transdermal patches 100 <em>µg</em> were applied from the second day of the cycle and continued every other day. Then, each patch was removed after four days. In the control group (n=45), oral estradiol valerate 6 <em>mg</em> was started at the same time and continued daily.<br />
Results: There was a significant difference in estradiol level on the day of progesterone administration and the day of embryo transfer between the two groups (p=0.001 in both), but no significant difference was observed between them in biochemical and clinical pregnancy rates (32.6% <em>vs</em>. 33.3%, p=1.000 and 30.2% <em>vs</em>. 33.3%, p=0.810, respectively). <br />
Conclusion: It is suggested that estradiol transdermal patches be used instead of oral estradiol in FET cycles. Due to the reduced costs, drug dose, and emotional stress as well as the simplicity of the protocol for patients.</p>
Frozen-thawed embryo transfer, Transdermal estradiol patchs, Endometrial preparation, Pregnancy rate
097
104
https://www.jri.ir/article/655
https://www.jri.ir/documents/fullpaper/en/655.pdf
RobabDavarResearch and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran1517
SimaJanatiResearch and Clinical Center for Infertility, Dezful University of Medical Sciences, Dezful, Iransjanati@dums.ac.ir1127
FereshtehMohseniResearch and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran1518
MehdiKhabazkhoobDepartment of Epidemiology, Faculty of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran1519
SoheilaAsgariDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iranسهيلاعسگري551
en
27141465
Laparoscopic Fimbrioplasty and Neosalpingostomy in Female Infertility: A Review of 402 Cases at the Gynecological Endoscopic Surgery and Human Reproductive Teaching Hospital in Yaoundé-Cameroon
<p>Background: More than 70 million couples suffer from infertility worldwide. The aim of this study was to evaluate the fertility outcomes after laparoscopic fimbrioplasty and neosalpingostomy in female infertility.<br />
Methods: Laparoscopic distal tuboplasty was carried out for 402 cases at the Gynecological Endoscopic Surgery and Human Reproductive Teaching Hospital in Yaoundé-Cameroon in Central Africa from December 2002 to December 2007. Laparoscopic fimbrioplasty and neosalpingostomy were done using bipolar electrocoagulation and conventional endoscopic instruments. Log-rank test was used to compare cumulative rate curves of intrauterine pregnancy with respect to the tubal stages. P<0.05 was considered statistically significant.<br />
Results: The mean age of the patients was 31.6±5.45 years. Secondary infertility was the most frequent type of infertility (70.14%). The laparoscopic tubal surgery done consisted of fimbrioplasty in 185(46%) cases and neosalpingostomy in 217(54%) cases. Of 260 women followed up after tuboplasty, there were overall 74(28.48%) pregnancies; 68(26.1%) intrauterine pregnancies and 6(2.3%) ectopic pregnancies. Pregnancy rates were significantly associated to the tubal stage (63% in stage 1, 15% in stage 3 and 00% in stage 4; p<0.001) and the adnexal adhesion scores (73.91% in the absence of adnexal adhesions and 8.8% in the case of a severe adnexal adhesion score). Of the 68 intrauterine pregnancies, there were 60(88%) live births and 8(12%) spontaneous abortions.<br />
Conclusion: It is believed that laparoscopic fimbrioplasty and neosalpingostomy should be the preferred choice when faced with tubal distal occlusion in a context of female infertility. This implies that training in endoscopic surgery should be regarded as an important issue in developing countries.</p>
Adnexal adhesion, Fimbrioplasty, Infertility, Laparoscopy, Neosalpingostomy, Tubal stage
104
110
https://www.jri.ir/article/661
https://www.jri.ir/documents/fullpaper/en/661.pdf
JeanKasiaGynecological Endoscopic Surgery and Human Reproductive Teaching Hospital, Yaoundé, Cameroon1539
JeanNgowaGynecological Endoscopic Surgery and Human Reproductive Teaching Hospital, Yaoundé, Cameroonjdkemfang@yahoo.fr1540
YolandeMimboeDepartment of Obstetrics and Gynaecology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon1541
MichelToukamLaboratory of Clinical Biology, Gynecological Endoscopic Surgery and Human Reproductive Teaching Hospital, Yaoundé, Cameroon1542
AnnyNgassamGynecological Endoscopic Surgery and Human Reproductive Teaching Hospital, Yaoundé, Cameroon1543
ClaudeNoaGynecological Endoscopic Surgery and Human Reproductive Teaching Hospital, Yaoundé, Cameroon1544
EtienneBelingaGynecological Endoscopic Surgery and Human Reproductive Teaching Hospital, Yaoundé, Cameroon1545
AlexisMedouAnesthesia Unit, Gynecological Endoscopic Surgery and Human Reproductive Teaching Hospital, Yaoundé, Cameroon1546
en
27141466
The Relationship between Chlamydia trachomatis Genital Infection and Spontaneous Abortion
<p>Background: <em>Chlamydia trachomatis</em> is the etiology of most of sexually transmitted diseases. Colonization of <em>C. trachomatis</em> in the genital tract during early gestation has been associated with preterm birth, and preterm premature rupture of the membranes. The role of <em>C. trachomatis</em> on spontaneous abortion has not yet been proved completely. The aim of this study was to evaluate the frequency of <em>C. trachomatis</em> infection among pregnant women and its association with spontaneous abortion.<br />
Methods: This case-control study was conducted from August 2012 until January 2013. Totally, 218 women were included; 109 women with spontaneous abortion with gestation age between 10-20 weeks (cases), and 109 women with normal pregnancy with gestation age between 20-30 weeks (controls) in Sanandaj, Iran. DNA was extracted from endocervical swabs and a PCR test was conducted for detection of <em>C. trachomatis</em> infection in women using specific primers. Independent T-test and Chi-square were used for comparison of quantitative and qualitative variables, respectively, and p<0.05 was considered significant.<br />
Results: The total prevalence of <em>C. trachomatis</em> infection was 38(17.43%) in endocervical swabs of women. However, the number of cases with <em>C. trachomatis</em> infections was 25 out of 109(22.9%) in the case group and 13 out of 109(11.9%) in control group, respectively. Association between chlamydia infection and spontaneous abortion was statistically significant (OR=2.198, CI 95%: 1.058-4.56).<br />
Conclusion: Our study showed that <em>C. trachomatis</em> infection was associated with spontaneous abortion. Thus, screening and treatment of pregnant women may prevent this adverse pregnancy outcome.</p>
Chlamydia trachomatis, Genital infection, Miscarriage, Pregnancy, Spontaneous abortion
110
117
https://www.jri.ir/article/647
https://www.jri.ir/documents/fullpaper/en/647.pdf
AmjadAhmadiCellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran1487
MazaherKhodabandehlooCellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iranmazaher-kh@muk.ac.ir1488
RashidRamazanzadehCellular and Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran1489
FaribaFarhadifarDepartment of Obstetrics and Gynecology, Social Determinant of Health Research Center, Sanandaj, Iran1490
DaemRoshaniSocial Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran1491
EbrahimGhaderiDepartment of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran1492
NiloofarFarhangiBe’sat Hospital, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran1493
en
27141467
The Role of Religious Coping Strategies in Predicting Depression among a Sample of Women with Fertility Problems in Shiraz
<p>Background: One of the most common mental health problems among women with infertility problems is depression. Research has shown that religious beliefs and practices can help people to cope with difficult situations. The purpose of this study was to explore the role of different religious coping strategies in predicting depression in a group of infertile women in Shiraz.<br />
Methods: A total of 72 women with fertility problems were recruited from several private infertility clinics in Shiraz using convenience sampling. The participants completed the research questionnaires including Beck Depression Inventory and Religious Coping Scale. The Religious Coping Scale consists of five dimensions including practice, active, passive, benevolent reappraisal and negative religious coping. Descriptive statistics (frequency percentage, mean and standard deviation), Pearson’s correlation and simultaneous multiple regression analysis were used for data analysis using SPSS version 16. A p-value less than 0.05 was considered statistically significant.<br />
Results: The present study showed that about 30% of women with fertility problems experienced the symptoms of depression. The findings also indicated that the most commonly used religious coping strategy was practice religious coping, while the least commonly used religious coping strategies were passive and negative religious coping. The findings also showed that active religious coping, practice religious coping and benevolent reappraisal coping predicted depression reduction.<br />
Conclusion: This study highlights the effect of religious coping on depression reduction of women with fertility problems. In other words, women who used religious coping strategies were less likely to experience depression symptoms.</p>
Coping behavior, Depression, Infertility, Religious beliefs, Women
117
123
https://www.jri.ir/article/659
https://www.jri.ir/documents/fullpaper/en/659.pdf
AbdulazizAflakseirDepartment of Clinical Psychology, School of Education and Psychology, Shiraz University, Shiraz, IranAbdulazizAflakseiraaflakseir@shirazu.ac.ir1186
MansourehMahdiyarDepartment of Clinical Psychology, School of Education and Psychology, Shiraz University, Shiraz, Iran1533
en
27141468
Socio-Demographic Correlates of Women’s Infertility and Treatment Seeking Behavior in India
<p>Background: Infertility is an emergent issue in India. Until recently, very few studies have understood the patterns and consequences of infertility in India. Family planning programs in India also viewed exclusively the patterns and determinants of overfertility rather than infertility. Furthermore, there is the lack of information about treatment seeking behavior of infertile couples. Therefore, this paper aimed to examine the extent of infertility and treatment seeking behavior among infertile women in India. An attempt was also made to evaluate the effects of socio-demographic factors on treatment seeking behavior.<br />
Methods: The study used the data from the District Level Household and Facility Survey carried out in India during 2007-08. Several statistical techniques such as chi-square test, proportional hazard model and binary logistic regression model were used for the analysis.<br />
Results: Approximately, 8% of currently married women suffered from infertility in India and most of them were secondary infertile (5.8%). Within India, women’s infertility rate was the highest in west Bengal (13.9 percent) and the lowest in Meghalaya (2.5 percent). About 80% of infertile women sought treatment but a substantial proportion (33%) received non-allopathic and traditional treatment due to expensive modern treatment and lack of awareness.<br />
Conclusion: In the context of policy response, it can be said that there is a need to improve the existing services and quality of care for infertile women. Treatment for infertility should be integrated into the larger reproductive health packages.</p>
Awareness, Determinants, Infertility, Primary infertility, Secondary infertility, Treatment seeking, Treatment
123
133
https://www.jri.ir/article/652
https://www.jri.ir/documents/fullpaper/en/652.pdf
SanjitSarkarInternational Institute for Population Sciences, Mumbai, Indiasanjitiips@gmail.com1515
PallaviGuptaInternational Institute for Population Sciences, Mumbai, India1516
en
27141469
Ovarian Malignant Mixed Germ Cell Tumor: A Case of Unusual Presentation as Molar Pregnancy
<p>Background: This research was conducted to introduce a patient with rare ovarian mixed germ cell tumor, presented as molar pregnancy.<br />
Case Presentation: The patient was a 16 year old woman admitted with diagnosis of molar pregnancy. Abdominal enlargement was the only complaint. She had a large pelvic mass in physical examination. The first diagnosis was molar pregnancy due to previous ultrasonic reports and positive βeta HCG. Urine pregnancy test was positive. As suction curettage was performed for her, surprisingly, the size of uterus was normal and no molar tissue was found in pathologic examination. At intraoperative ultrasound exam, an extra-uterine heterogeneous mass was found. Extra-uterine mass was confirmed by CT and MRI done after suction curettage. Mixed germ cell tumor was confirmed by histological examination after laparatomy and removing tumoral mass. Finally, she received Bleomycin, Etoposide and Cisplatin (BEP) regimen in four courses and Vincristine, Actinomycin D (Dactinomycin) and Cyclophosphamide (VAC) regimen in two courses and Diphereline for saving the other ovary.<br />
Conclusion: Some young patients misinterpret the early symptoms of an ovarian neoplasm as those of pregnancy which can lead to a delay in the diagnosis.</p>
BEP, Embryonal carcinoma, Germ cell tumor, Molar pregnancy, Tumor marker, VAC, Yolk sac tumor
133
137
https://www.jri.ir/article/665
https://www.jri.ir/documents/fullpaper/en/665.pdf
SoheilaAminimoghaddamGynecology Oncology Department, Iran University of Medical Sciences, Tehran, IranDr_aminimoghaddam@ yahoo.com1360
ImanMohseniGynecology Oncology Department, Iran University of Medical Sciences, Tehran, Iran1568
AzadehAfzalzadehGynecology Oncology Department, Iran University of Medical Sciences, Tehran, Iran1569
ShookaEsmaeeliGynecology Oncology Department, Iran University of Medical Sciences, Tehran, Iran1570