en
1726-7536
1735-8507
69
2139
288
gregorian
2017
3
15
18
2
online
1
fulltext
en
28868249
Should Subclinical Hypothyroidism Be an Exclusion Criterion for the Diagnosis of Polycystic Ovary Syndrome?
<p>Background: The purpose of the study was to examine whether patients with subclinical hypothyroidism (SCH) should be excluded before making a diagnosis of polycystic ovary syndrome (PCOS).<br />
Methods: Seven hundred sixteen patients, 462 with true PCOS, 31 with PCOS-SCH, and 223 normal cycling women were enrolled. Clinical, metabolic, and hormonal parameters among the groups were investigated. Continuous variables were compared by one-way analysis of variance. Proportions were compared using Z test. Fisher test was used to compare categorical variables. Simple correlation was performed using Spearman’s coefficient. Correlation between thyroid stimulating hormone (TSH) and dependent variables were performed using backward multiple regression. The significance level was set at 0.05.<br />
Results: True polycystic ovary and polycystic ovary with subclinical hypothyroidism patients presented similar anthropometrical parameters. C-peptide was higher in polycystic ovary patients than in the other groups (p=0.014). Prevalence of glucose intolerance (p=0.186) and insulin resistance (p=0.293) was not statistically different in polycystic ovary and polycystic ovary with subclinical hypothyroidism. TSH levels showed positive correlation with lean body mass (p=0.032), total cholesterol (p=0.046, insulin (p=0.048) and prolactin (p=0.047). Backward multiple regression model retained TC, insulin, and PRL as predictors of TSH levels (p=0.011).<br />
Conclusion: Anthropometric parameters and ovary morphology were similar in both PCOS and PCOS-with-SCH patients. Regarding hormones, only C-peptide was higher in PCOS group. TSH correlated with total cholesterol, insulin, and prolactin. Before PCOS diagnosis, the exclusion criterion thyroid dysfunction should be standardized and subclinical hypothyroidism should not exclude a diagnosis of PCOS.</p>
Hyperandrogenism, Hypothyroidism, Polycystic ovary syndrome, Thyroid hormones
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https://www.jri.ir/article/703
https://www.jri.ir/documents/fullpaper/en/703.pdf
Sebastiãode-MedeirosFederal University of Mato Grosso, Cuiabá, Mato Grosso, Brazilde.medeiros@terra.com.br1684
MárciaYamamotoTropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil1685
Matheusde-MedeirosTropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil1686
JacklyneBarbosaTropical Institute of Reproductive Medicine and Menopause, Cuiabá, Mato Grosso, Brazil1687
RobertNormanUniversity of Adelaide, Robinson Research Institute and Fertility SA, Adelaide, Australia1688