Journal ID (publisher-id): JRI
Publisher: Avicenna Research Institute
Copyright © 2014 Avicenna Research Institute
open-access: This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
Print publication date: Season: Jul-SepYear: 2014
Volume: 15Issue: 3
First Page: 170Last Page: 170
Publisher Id: JRI-15-170
|Letter to Editor on “Correlation of the Day 3 FSH/LH Ratio and LH Concentration in Predicting IVF Outcome”|
|Department of Obstetrics and Gynecology, University of Siena, Policlinico Santa Maria Le Scotte, Siena, Italy
|*Corresponding Author: Giuseppe Morgante, Department of Obstetrics and Gynecology, University of Siena, Policlinico Santa Maria Le Scotte, 53100 Siena, Italy. E-mail:firstname.lastname@example.org
We read with interest the study by Prasad et al. (1), on Correlation of Day 3 FSH/LH Ratio and LH Concentration in Predicting IVF Outcome. In this study, they demonstrated that elevated day 3 FSH/LH ratio is associated with inferior outcome in IVF treatment cycles and it could be used as an additional predictor of decreased ovarian reserve. Surprisingly, two of our clinically relevant studies went unnoticed. While studying patients undergoing COH for IVF, with a favorable prognosis a priori, day 3 FSH: LH ratio, but not LH level, was found to predict IVF treatment outcome. Moreover, the FSH/LH ratio cutoff levels differ between those using the GnRH-agonist or GnRH-anta-gonist COH protocols. We demonstrated that patients undergoing ovarian stimulation using the GnRH antagonist with FSH/LH ratios >2, or using agonist protocols with FSH/LH ratios >3, achieved significantly lower pregnancy rates (2). Furthermore, in a subsequent study, we observed significantly higher number of top-quality embryos, and higher implantation and clinical pregnancy rates in patients undergoing COH for IVF, using HMG compared with rFSH (3).
The authors declare no conflict of interest.
|1.||PrasadS, GuptaT, DivyaA. Correlation of the day 3 FSH/LH ratio and LH concentration in predicting IVF outcomeJ Reprod Infertil.2013;14(1):23–28.|
|2.||OrvietoR, MeltzerS, RabinsonJ, GemerO, AntebyEY, NahumR. Does day 3 luteinizing-hormone level predict IVF success in patients undergoing controlled ovarian stimulation with GnRH analogues?Fertil Steril.2008;90(4):1297–300.|
|3.||OrvietoR, HomburgR, MeltcerS, RabinsonJ, AntebyEY, NahumR. HMG improves IVF outcome in patients with high basal FSH/LH ratio: a preliminary studyReprod Biomed Online.2009;18(2):205–8.|