TY - JOUR T1 - Effects of Pharmaceutical Medications on Male Fertility T2 - Journal of Reproduction & Infertility JT - Journal of Reproduction & Infertility SP - 03 EP - 12 VL - 13 IS - 1 PY - 2012 SN - 2251-676X L1 - https://www.jri.ir/documents/fullpaper/en/482.pdf L2 - https://www.jri.ir/article/482 UR - https://www.jri.ir/en/currentissue.aspx?id=50 PB - Avicenna Research Institute AU - R. Brezina, Paul AU - N. Yunus, Fahd AU - Zhao, Yulian AB - The number of couples seeking consultation for infertility problems has steadily increased over the past decade, affecting 10%-15% of the sexually active population. Abnormal semen production, a male factor infertility (MFI), is thought to be the cause of up to 50% of all infertilities in developed countries. There are potentially many different causes of male infertility, including hormonal, anatomical, and secondary to exposure to exogenous substances. In many cases of MFI, a definitive cause for abnormalities is never identified. Recently, the research community has given greater attention to identifying causes of MFI ranging from genetic Y chromosome microdeletions to mechanisms of environmental damage on sperm production. Still evolving, is a clear understanding of how many pharmaceutical medications may cause MFI, which is often treatable and reversible. In this review we will out-line the data regarding various pharmaceutical medications that have been investigated as possible causes of MFI. CY - Tehran, Iran KW - Male infertility KW - Medications KW - Pregnancy KW - Review KW - Sperm LA - English