TY - JOUR T1 - Effects of Varicocelectomy on Anti-sperm Antibody in patients with Varicocele T2 - Journal of Reproduction & Infertility JT - Journal of Reproduction & Infertility SP - 73 EP - 79 VL - 14 IS - 2 PY - 2013 SN - 2251-676X L1 - https://www.jri.ir/documents/fullpaper/en/527.pdf L2 - https://www.jri.ir/article/527 UR - https://www.jri.ir/en/currentissue.aspx?id=55 PB - Avicenna Research Institute AU - Bonyadi, Mohammad Reza AU - Madaen, Sayyed Kazem AU - Saghafi, Maryam AB - Background: Anti-sperm antibody (ASA) can decrease sperm motility and, therefore, it is a cause of male infertility. The aim of this study was to evaluate the effects of varicocelectomy on anti-sperm antibody in patients with varicocele. Methods: This observational study was conducted on 90 patients with varicocele at Sina and Imam Khomeini hospitals during 2006 to 2009. All varicocelectomy candidates were selected for ASA assessment both in semen and serum before and after surgery. ASA level was measured using a direct method for semen and an indirect method of Sperm MAR test, for serum. Paired t-test and McNemar's test were used for data analysis, and p<0.05 was considered statistically significant. Results: ASA level in semen was 13.7% before, and 15.7% after three month of varicocelectomy (p=0.881). Serum level of ASA before and after surgery were 13.6% and 21.7%, respectively (p=0.033). Three parameters including sperm count, motility and morphology showed recovery following, varicocelectomy, but only the difference in sperm motility was significant (p<0.05). Conclusion: This study showed that varicocelectomy has no effect on semen ASA. Although serum antibody has been shown to increase after varicocelectomy but sperm motility will improve. Varicocelectomy seems to have a beneficial effect on semen parameters in infertile men with varicocele. CY - Tehran, Iran KW - Anti-sperm Antibody KW - Infertility KW - Sperm motility KW - Varicocelectomy LA - English