en 36919051 <p>Background: Gestational trophoblastic neoplasia (GTN) is a group of tumors highly responsive to chemotherapy. It has been suggested that cancer therapies have detrimental effects on female fertility. Anti-M&uuml;llerian hormone (AMH) is considered fertility potential and ovarian reserves in women. The aim of this study was to compare serum AMH levels between the patients with GTN treated with chemotherapy and the patients with hydatidiform mole who underwent suction curettage without receiving any chemotherapy.&nbsp;<br /> Methods: In 35 patients with GTN, serum AMH levels were measured before suction curettage and after the administration of chemotherapy and compared with serum AMH levels measured in 35 patients with hydatidiform mole, who did not receive any chemotherapy as a control. In controls, serum levels of AMH were measured before suction curettage and at the time when beta human chorionic gonadotrophin (&szlig;-hCG) levels approached zero concentration.&nbsp;<br /> Results: The mean serum AMH levels in the GTN group were significantly lower than those measured in the control group after chemotherapy. In addition, serum AMH levels measured after intervention in each group significantly decreased compared to the basal levels (p=0.034). Serum AMH levels showed significant differences between the patients who received chemotherapy regimens with methotrexate (MTX) alone, actinomycin-D (Act-D) alone, or the combination of MTX and Act-D (p=0.001).&nbsp;<br /> Conclusion: Our study showed that fertility preservation is of great importance in patients with GTN treated with chemotherapy. Furthermore, both MTX and Act-D could have potential adverse effects on ovarian reserve.</p> Anti- mullerian hormone, Chemotherapy, Fertility, Gestational trophoblastic neoplasia, Hydatidiform mole 43 49 https://www.jri.ir/article/140173 https://www.jri.ir/documents/fullpaper/en/140173.pdf MehrangizZamaniFatemieh Hospital, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran, Hamadan, Iran122487FatemehMohsenpourFatemieh Hospital, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran, Hamadan, Irandrfmohsenpour@gmail.com122488FaezehTorkzabanFaculty of Rehabilitation, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran122489NazaninAtrvashFatemieh Hospital, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran, Hamadan, Iran122490AmirMajlesiBesat Hospital, Hamadan University of Medical Sciences and Health Services, Hamadan, Iran122491AmirfazelTorkzabanNational Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran122492