en <p>Background: Although the balanced carriers of Robertsonian translocations (ROBs) typically exhibit normal phenotypes, they may experience recurrent abortions or have offspring with chromosomal disorders. A proposed mechanism is the inter-chromosomal effect (ICE), where disrupted meiotic segregation may increase aneuploid gamete production. This study presents a male case carrier of t(13;14) who had a deceased child with Down syndrome (DS) and investigates t(13;14) as a potential factor contributing to the birth of a child with DS.<br /> Case Presentation: A couple with a history of recurrent abortions and a deceased child with DS was referred to a medical genetics laboratory. Karyotype analysis revealed that the male partner was a carrier of t(13;14) (45,XY,t(13;14)), while the female partner had a normal karyotype. The couple&rsquo;s subsequent pregnancy resulted in a healthy female fetus inheriting t(13;14). The deceased child had a karyotype of 47, XY, +21, consistent with DS. In this study, the role of t(13;14) and ICE as potential contributors to the birth of a child with DS was explored.<br /> Conclusion: Prenatal screening for carriers of ROBs is strongly recommended to assess the risk of unbalanced chromosomal disorders in offspring.</p> Down syndrome, Inter-chromosomal effect, Robertsonian translocation 75 80 https://www.jri.ir/article/140293 /documents/fullpaper/en/140293.pdf SahraSahraeeanDr. F. Nabipour Pathobiology laboratory, Kerman, Iran122972AsiyehJebelliDepartment of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran122973SaeedGhadimi HaddadanLegal Medicine Research Center, Iranian Legal Medicine Organization, Tehran, Iran122974KobraTayyariLegal Medicine Research Center, Iranian Legal Medicine Organization, Tehran, Iran122975LeilaEmrahiLegal Medicine Research Center, Iranian Legal Medicine Organization, Tehran, Iranleila.emrahi@gmail.com122976