en 23926566 Background: Preeclampsia is a pregnancy-specific syndrome that may be life-threatening, especially to the fetus. Several causes have been reported that may have a possible role in the development of the disorder. Interleukin-10 affect maternal intravascular inflammation, as well as endothelial dysfunction. The aim of this study was to investigate the association between IL-10 G-1082A polymorphism and pre-eclampsia. Methods: A total of eighty-eight pregnant women with preeclampsia and 100 women with normal pregnancy attending the Gynecological unit of Government Maternity Hospital, Petlaburz, Hyderabad, India, were considered for the study. A standard amplification refractory mutation system (ARMS) PCR was carried out for genotyping IL-10 G-1082A promoter polymorphism in all the participants. Genotypic distribution of the control and patient groups were compared with values predicted by Hardy-Weinberg equilibrium using χ2 test. Odd ratios (OR) and their respective 95% confidence intervals were used to measure the strength of association between IL-10 gene polymorphism and preeclampsia. Results: The frequencies of IL-10 G-1082A genotypes, GG, GA and AA, were 17.8%, 41.09% and 41.09% in women with preeclampsia and 25%, 28% and 47% in the controls respectively. There was no significant difference in the distribution of genotypes and alleles of IL-10 G-1082A between the two groups (Test power=0.66). Conclusion: The present study suggests that the IL-10 G-1082A gene promoter polymorphism is not a major genetic regulator in the etiology of preeclampsia. ARMS PCR, Cytokines, Interleukin-10, Polymorphism, Preeclampsia 62 67 https://www.jri.ir/article/525 https://www.jri.ir/documents/fullpaper/en/525.pdf SowmyaSabnavisInstitute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad, IndiaSowmyaSabnavis1138ArunaRamaiahGovernment Maternity Hospital, Petlaburz, Hyderabad, IndiaArunaRamaiah1139TellaSunithaInstitute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad, Indiaتلاسونيتا840PratibhaNallariDepartment of Genetics, Osmania University, Hyderabad, IndiaPratibhaNallari943AkkaJyothyInstitute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad, India842AnanthapurVenkateshwariInstitute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad, Indiavenkateshwari@yahoo.com1140