en 31897389 <p>Background: Failure to respond adequately to standard protocols and to recruit adequate follicles is called &lsquo;poor ovarian response&rsquo;. The relationships between metabolic alterations and NUCB2/Nesfatin-1 levels were explored in patients with polycystic ovary syndrome (PCOS) undergoing<em> in vitro</em> fertilization/intracytoplasmic sperm injection.&nbsp;<br /> Methods: This case-control study involved 20 infertile women with PCOS and 20 control women diagnosed as poor ovarian responders stimulated with a GnRH antagonist. Blood samples were taken during ovum pick-up and follicular fluids (FF) were obtained from a dominant follicle from the subjects. Samples were analyzed by using ELISA. Statistical analysis was performed with SPSS version 20. Data are expressed as means &plusmn; standard deviation (SD).<br /> Results: Blood NUCB2/Nesfatin-1 levels in PCOS were significantly lower (p=0.011) while the NUCB2/Nesfatin-1 levels of FF in poor ovarian response (POR) were higher, but not statistically significant.&nbsp; Insulin, total testosterone, fasting glucose, homeostasis model assessment, and insulin resistance index in women with POR decreased when compared with PCOS. Blood NUCB2/Nesfatin-1 levels were significantly higher than FF NUCB2/Nesfatin-1 levels in both groups (p&lt;0.001). Moreover, a positive correlation was detected between blood NUCB2/Nesfatin-1 and testosterone (p=0.602, r=0.304), HOMA-IR (p=0.252, r=0.384), BMI (p=0.880, r=0.44) in PCOS, but it was not significant.&nbsp;<br /> Conclusion: NUCB2/Nesfatin-1 levels might be important in follicular growth in PCOS subjects undergoing IVF/ICSI with an antagonist protocol and NUCB2/Nesfatin-1 level could reliably help to predict poor ovarian response.</p> PCOS, Infertility, Nesfatin-1, Follicular fluid, Glucose metabolism, Pregnancy 225 231 https://www.jri.ir/article/60060 https://www.jri.ir/documents/fullpaper/en/60060.pdf ZekiyeCatakDepartment of Clinical Biochemistry, University of Health Sciences, Elazig Fethi Sekin City Hospital, Elazig, Turkey61965SeydaYavuzkirDepartment of Obstetrics and Gynecology, School of Medicine, Firat University, Elazig, Turkey61966EsraKocdemirDepartment of Clinical Biochemistry, Kovancilar State Hospital, Taipei City, Turkey61967KaderUgurDepartment of Internal Medicine (Endocrinology and Metabolism Diseases), School of Medicine, Firat University, Elazig, Turkey61968MeltemYardimDepartment of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group), Medical School, Firat University, Elazig, Turkey61969İbrahimSahinDepartment of Medical Biology, Medical School, Erzincan Binali Yildirim University, Elazig, Turkey61970EsraAgirbasSchool of Medicine, Medical School Student, Firat University, Elazig, Turkey61971SuleymanAydinDepartment of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group), Medical School, Firat University, Elazig, Turkeysaydin1@hotmail.com61972