en 32500016 <p>Background: The present study aimed to determine the association between pregnancy-associated plasma protein A (PAPP-A) and Gestational Diabetes Methods (GDM) to detect a risk factor for predicting GDM at gestational weeks 11-14.<br /> Methods: This analytical prospective study recruited 284 pregnant women presenting to six healthcare centers of Qazvin, Iran from February to December 2016. PAPP-A was measured at gestational weeks 11-14 and glucose tolerance test was conducted at gestational weeks 24-28. The participants were assigned into two groups of exposure (reduced PAPP-A) and non-exposure (normal PAPP-A). The association between GDM and PAPP-A was studied. The number of women in exposure group were 201 and 83 in the non-exposure group. Differences between groups were assessed by the Mann&ndash;Whitney, Chi-square, T test, logistic regression analysis and ROC Curve with a significance level of 0.05.&nbsp;<br /> Results: Twenty eight (33.73%) patients of the exposure group and 17 (8.46%) of non-exposure group developed GDM. There was a significant difference between the two groups in terms of GDM (p&lt;0.001) and the risk of GDM was 3.98 fold higher in the exposure group (reduced PAPPA <em>mu/L</em>) than that of the non-exposure group (CI=2.39-6.65, p&lt;0.001). Also, 53.3% of the exposure group and 46.7% of the non-exposure group were diagnosed with GDM (p=0.02). There was a significant difference in GDM between the groups and the risk of GDM was 1.85 times higher in the exposure group (reduced PAPPA MOM) than that in the control group (CI=1.09-3.15, p=0.020). According to the ROC curve results, PAPP-A and MOM are acceptable indicators for predicting GDM.<br /> Conclusion: A low PAPP-A level (MOM, MU/L) as a new risk factor for GDM can help early prediction and prevent maternal and fetal complication by timely treatment.</p> Gestational diabetes, Pregnancies, Pregnancy associated plasma protein A 130 138 https://www.jri.ir/article/60076 https://www.jri.ir/documents/fullpaper/en/60076.pdf SomayehRamezaniStudent Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran62030MahboubehAhmadi DoulabiMidwifery and Reproductive Health Research Center, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iranmah1372@yahoo.com62029HamidSaqhafiSchool of Paramedical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran62031MahmoodAlipoorDepartment of Biostatistics, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran62032