en 27110518 <p>Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that is associated with increased inflammation, insulin resistance, and elevated risk of metabolic complications. hs-CRP is the most reliable marker of inflammation in PCOS patients. When hs-CRP is elevated, it can indicate increased risk of cardiovascular disease. The purpose of the study was to determine if a certain value of HbA_1c in PCOS patients should alert clinicians to increased inflammation (as defined by hs-CRP &gt;2 <em>mg/l</em>), thus potentially be indicative of increased risk of cardiovascular disease.<br /> Methods: A cohort study was conducted on female patients between the ages of 20 to 45 years who fulfilled the National Institute of Health criteria for PCOS. De-identified data of 46 patients with PCOS were obtained. All clinical tests were conducted after a 12 <em>hr</em> overnight fast. hs-CRP was measured by latex-enhanced immunonephelometry. Logistic regression analysis was conducted to assess the association between hs-CRP and HbA_1c.<br /> Results: When various HbA_1c levels were considered, a cutoff of 5.3% correctly classified patients with hs-CRP &gt;2 <em>mg/l</em> at 80.4%. Sensitivity was 83.3% and specificity was 75%.<br /> Conclusion: An HbA_1c cut off of 5.3% may be appropriate to initiate efforts for early detection of increased inflammation as a potential sign of risk for cardiovascular disease.</p> Cardiovasculer disease, HbA1c, hs-CRP, Inflammation, Polycystic ovary syndrome 203 207 https://www.jri.ir/article/646 https://www.jri.ir/documents/fullpaper/en/646.pdf RamiMortadaDepartment of Internal Medicine, School of Medicine-Wichita, University of Kansas, Wichita, Kansas, USA1483KenKallailDepartment of Internal Medicine, School of Medicine-Wichita, University of Kansas, Wichita, Kansas, USAkkallail@kumc.edu1484FrankDongDepartment of Preventive Medicine and Public Health, School of Medicine-Wichita, University of Kansas, Wichita, Kansas, USA1485SidikaKarakasDivision of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, University of California-Davis, Sacramento, USA1486