en 27110519 <p>Background: The purpose of this study was to evaluate the effect of needle type on pain and bleeding during oocyte pick-up (OPU).<br /> Methods: From May through November 2013, patients undergoing OPU from a single follicle without any analgesic treatment were including this study. Eligible patients (n=75) were randomized 1:1 to undergo the procedure with either a reduced needle (17 gauge body, 20 gauge tip; RN group) or a standard needle (19 gauge; SN group). Overall pain was assessed by patients using a visual analogue scale (VAS), and vaginal bleeding after the procedure was recorded. Fisher exact, t-test or Wilcoxon test were used, and p&lt;0.05 was considered to be statistically significant.<br /> Results: The percentage of mature oocytes was 86.5% in the RN group and 91.7% in the SN group. Pain during OPU was significantly lower in the RN group than in the SN group (mean VAS score&plusmn;SD: 3.2&plusmn;2.0 <em>cm vs.</em> 4.9&plusmn;2.2 <em>cm</em>, p&lt;0.01; mean&plusmn;SD).&nbsp;The frequency of bleeding in the RN group was also significantly lower than that in the SN group (26.3% vs. 48.6%; p&lt;0.05). No significant differences were found between the two groups with regard to fertilization and pregnancy rates.<br /> Conclusion: The newly designed needle significantly reduced pain and vaginal bleeding associated with single-follicle OPU in patients receiving no analgesic treatment, in comparison with a standard needle. The RN had no adverse effect on the quality of retrieved oocytes.</p> Aspiration needle, Bleeding, Oocyte aspiration, Pain 207 212 https://www.jri.ir/article/656 https://www.jri.ir/documents/fullpaper/en/656.pdf KojiNakagawaDivision of Reproductive Medicine, Sugiyama Clinic, Tokyo, Japankoji@sugiyama.or.jp1521YayoiNishiDivision of Reproductive Medicine, Sugiyama Clinic, Tokyo, Japan1522MasayoKaneyamaDivision of Reproductive Medicine, Sugiyama Clinic, Tokyo, Japan1523RieSugiyamaCenter for Reproductive Medicine and Endoscopy, Sugiyama Clinic Marunouchi, Tokyo, Japan1524HiroshiMotoyamaCenter for Reproductive Medicine and Endoscopy, Sugiyama Clinic Marunouchi, Tokyo, Japan1525RikikazuSugiyamaDivision of Reproductive Medicine, Sugiyama Clinic, Tokyo, Japan1526