en
1726-7536
1735-8507
69
2139
288
gregorian
2015
3
10
16
2
online
1
fulltext
en
25927028
An Association Study between INSR/NsiI (rs2059806) and INSR/PmlI (rs1799817) SNPs in Women with Polycystic Ovary Syndrome from West Azerbaijan Province, Iran
<p>Background: It has been demonstrated that insulin signaling pathway related genes have important roles in polycystic ovary syndrome (PCOS) risk. The goal of present investigation was to assess the potential association between INSR/NsiI (rs2059806) and INSR/PmlI (rs1799817) SNPs and PCOS.<br />
Methods: 50 women with PCOS and 47 normal controls entered the study. NsiI and PmlI SNPs in the INSR gene were determined by RFLP-PCR.<br />
Results: INSR/NsiI (rs2059806) SNP GG, GA, AA, G and A genotypic and allelic frequencies were 45(90%), 5(10%), 0(0%), 95(95%) and 5(5%) in cases and 41(87.2%), 6(12.8%), 0(0%), 88(93.6%) and 6(6.38%) in controls, respectively. INSR/PmlI (rs1799817) SNPs resulted in three genotypes of CC, CT, and TT with C and T alleles. The frequencies of PmlI (rs1799817) SNPs in the INSR gene were 37(37%) and 63(63%) in cases, also 39(41.49%) and 55 (58.51%) in controls regarding T and C alleles. The frequencies of PmlI (rs1799817) SNPs in the INSR gene were 4(8%), 29(58%), and 17(34%) in cases, also 5(10.64%), 29(61.7%), and 13(27.66%) in controls regarding TT, TC, and CC genotypes, respectively.<br />
Conclusion: The present study as the first investigation of its own kind in Iranian Azeri Turkish women, reported no association between NsiI (rs2059806) and PmlI (rs1799817) SNPs in the INSR gene and PCOS risk.</p>
Insulin/genetics, Polycystic ovary syndrome, Polymorphism, Receptor
109
113
https://www.jri.ir/article/623
https://www.jri.ir/documents/fullpaper/en/623.pdf
MortezaBagheriCellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran1409
IsaAbdi-RadCellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iranisaabdirad@yahoo.com1410
NimaHosseini-JazaniFood and Beverages Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran1411
RasoulZarrinFood and Beverages Safety Research Center, Urmia University of Medical Sciences, Urmia, Iran1412
FaribaNanbakhshReproductive Health Research Center, Department of Obstetrics and Gynecology, Urmia University of Medical Sciences, Urmia, Iran1413
NaumanMohammadzaieCellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran1414