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    <journal-meta>
      <journal-id journal-id-type="nlm-ta">J Reprod Infert</journal-id>
      <journal-id journal-id-type="publisher-id">arij001</journal-id>
      <journal-title-group>
        <journal-title>Journal of Reproduction &amp; Infertility</journal-title>
      </journal-title-group>
      <issn pub-type="ppub">2228-5482</issn>
      <issn pub-type="epub">2251-676X</issn>
      <publisher>
        <publisher-name>Avicenna Research Institute</publisher-name>
      </publisher>
    </journal-meta>

    <article-meta>
      <article-id pub-id-type="publisher-id">jri140161</article-id>
      <article-id pub-id-type="doi"></article-id>
      <article-id pub-id-type="pmid"></article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
             <subject></subject> 
        </subj-group>
        <subj-group>
            <subject></subject>
        </subj-group> 
      </article-categories>
      <title-group>
        <article-title>A Homogeneous Ensemble of Robust Pre-defined Neural Network Enables Automated Annotation of Human Embryo Morphokinetics</article-title>
      </title-group>
        <contrib-group><contrib contrib-type="author"><name><surname>Danardono</surname><given-names>Gunawan B</given-names></name></contrib><aff>IRSI Research and Training Center, Jakarta, Indonesia</aff><aff>Faculty of Engineering and Information Technology, Swiss German University, Tangerang, Indonesia</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Erwin</surname><given-names>Alva</given-names></name></contrib><aff>IRSI Research and Training Center, Jakarta, Indonesia</aff><aff>Faculty of Engineering and Information Technology, Swiss German University, Tangerang, Indonesia</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Purnama</surname><given-names>James</given-names></name></contrib><aff>Faculty of Engineering and Information Technology, Swiss German University, Tangerang, Indonesia</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Handayani</surname><given-names>Nining</given-names></name></contrib><aff>IRSI Research and Training Center, Jakarta, Indonesia</aff><aff>Morula IVF Jakarta Clinic, Jakarta, Indonesia</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Polim</surname><given-names>Arie A</given-names></name></contrib><aff>IRSI Research and Training Center, Jakarta, Indonesia</aff><aff>Morula IVF Jakarta Clinic, Jakarta, Indonesia</aff><aff>Department of Obstetrics and Gynecology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Boediono</surname><given-names>Arief</given-names></name></contrib><aff>IRSI Research and Training Center, Jakarta, Indonesia</aff><aff>Morula IVF Jakarta Clinic, Jakarta, Indonesia</aff><aff>Department of Anatomy, Physiology and Pharmacology, IPB University, Bogor, Indonesia</aff></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Sini</surname><given-names>Ivan</given-names></name></contrib><aff>IRSI Research and Training Center, Jakarta, Indonesia</aff><aff>Morula IVF Jakarta Clinic, Jakarta, Indonesia</aff></contrib-group>
      <pub-date pub-type="ppub">
        <day></day>
        <month></month>
        <year></year>
      </pub-date>
      <pub-date pub-type="epub">
        <day></day>
        <month></month>
        <year></year>
      </pub-date>
      <volume>23</volume>
      <issue>4</issue>
      <fpage>250</fpage>
      <lpage>257</lpage>
      <history>
        <date date-type="received">
          <day>11</day>
          <month>1</month>
          <year>2022</year>
        </date>
        <date date-type="accepted">
          <day>21</day>
          <month>3</month>
          <year>2022</year>
        </date>
      </history>
      <abstract>
      <p>
      &lt;p&gt;Background: The purpose of the current study was to reduce the risk of human bias in assessing embryos by automatically annotating embryonic development based on their morphological changes at specified time-points with convolutional neural network (CNN) and artificial intelligence (AI).&lt;br /&gt;
Methods: Time-lapse videos of embryo development were manually annotated by the embryologist and extracted for use as a supervised dataset, where the data were split into 14 unique classifications based on morphological differences. A compilation of homogeneous pre-trained CNN models obtained via TensorFlow Hub was tested with various hyperparameters on a controlled environment using transfer learning to create a new model. Subsequently, the performances of the AI models in correctly annotating embryo morphologies within the 14 designated classifications were compared with a collection of AI models with different built-in configurations so as to derive a model with the highest accuracy.&lt;br /&gt;
Results: Eventually, an AI model with a specific configuration and an accuracy score of 67.68% was obtained, capable of predicting the embryo developmental stages (t1, t2, t3, t4, t5, t6, t7, t8, t9+, tCompaction, tM, tSB, tB, tEB).&lt;br /&gt;
Conclusion: Currently, the technology and research of artificial intelligence and machine learning in the medical field have significantly and continuingly progressed in an effort to develop computer-assisted technology which could potentially increase the efficiency and accuracy of medical personnel&amp;rsquo;s performance. Nonetheless, building AI models with larger data is required to properly increase AI model reliability.&lt;/p&gt;

      </p>
      </abstract>
    </article-meta>
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