<p>Background: The purpose of the current study was to evaluate patient-oriented strategies encompassing individualized oocyte number (POSEIDON) criteria, validate stratification of low prognosis women, and prognosticate their reproductive potential in terms of cumulative live birth rate (CLBR) in Indian women.<br /> Methods: Out of 4048 women who underwent IVF/ICSI, 3287 women met the criteria for final evaluation of CLBR. They criteria were divided into (a) group 1a as cases with &lt;4 oocytes retrieved and 1b with 4-9 oocytes retrieved; (b) group 2a as cases with &lt;4 oocytes retrieved and 2b with 4-9 oocytes retrieved; (c) group 3 (&lt;35 years, AMH &lt;1.2 <em>ng/ml</em>, AFC &lt;5); and (d) group 4 (&ge;35 years, AMH &lt;1.2 <em>ng/ml</em>, AFC &lt;5). Non-POSEIDON group was sub-divided into normo-responders (10-20 oocytes) and hyper-responder (&gt;20 oocytes).<br /> Results: Overall CLBR was two-fold lower in POSEIDON group as compared to non-POSEIDON group (p&lt;0.001). For every one-year increase in the age, the odds of CLBR decreased by 4% (OR 0.96, CI 0.93-0.99) in POSEIDON group and by 5% (OR 0.95, CI 0.92-0.98) in non-POSEIDON group. For every unit increase in number of oocytes retrieved, the odds of CLBR increased by 1.22 times (OR1.22, CI 1.16-1.28) in POSEIDON group and by 1.08 times (OR 1.08, CI 1.05-1.11) in non-POSEIDON group. Among POSEIDON groups, the highest values in CLBR belonged to group 1b followed by 3, 2b, 4, 1a, and 2a.<br /> Conclusion: POSEIDON stratification of low-prognosis women undergoing IVF may be considered valid to prognosticate and counsel women undergoing IVF. Prospective studies will strengthen its validity among different ethnic populations.</p>