J Reprod Infert

arij001

Journal of Reproduction & Infertility

2228-5482 2251-676X

Avicenna Research Institute

jri140274

Fetal Brain Midline Structure Measurements: Cavum Septi Pellucidi and Corpus Callosum Indices in Multiple Views at Late Gestation

Borna

Sedigheh

Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Shabani

Azadeh

Preventative Gynecology Research Center, Taleghani Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Ghalandarpoor-Attar

Seyedeh Noushin

Obstetrics and Gynecology Department, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran

Ghalandarpoor-Attar

Seyedeh Mojgan

Maternal, Fetal, and Neonatal Research Center, Family Health Research Institute, Vali-E-Asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Ghorbani

Asghar

Department of Pediatrics, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran

26 3 172 180 25 5 2025 12 10 2025

Background: Few studies evaluated cavum septum pellucidum (CSP) and cor-pus callosum (CC) indices in late gestation. This study assessed CSP and CC indices, along with frontal lobe measurements, and examined correlations among parameters. Methods: A cross-sectional study was conducted at Imam Khomeini Hospital Complex on 150 fetuses at ≥36 weeks’ gestation. Transabdominal ultrasound was used to measure CSP length, width, trace length, and area in the axial view; frontal lobe thickness from anterior and posterior CSP margins in horizontal and vertical directions; and CC lengths and thicknesses. CSP trace length and area were also obtained in the midsagittal view. Data were analyzed using SPSS 23. Results: Mean gestational age, biparietal diameter (BPD), head circumference (HC), and estimated fetal weight (EFW) were 37.56±1.08 weeks, 90.73±3.20 mm, 326.58± 10.59 mm, and 2987.82±333.68 gr. In the trans-thalamic view, median CSP length, width, trace length, and area were 8.92 mm, 6.05 mm, 2.81 mm, and 0.49 mm². Median CSP height in the coronal view was 5.85 mm. In the midsagittal view, mean CC outer-to-outer length, inner-to-inner length, CSP trace length, and CSP area were 41.31±4.81 mm, 29.73±4.17 mm, 2.56±0.63 mm, and 0.36±0.19 mm². All CC and CSP indices correlated significantly with HC (p<0.05). Frontal bone–to–CSP anterior and posterior distances in axial and near-field views also correlated with HC (p=0.0001). Conclusion: This study provides normative measurements for CC, CSP, and frontal lobe indices at ≥36 weeks’ gestation. These values support late-gestation brain assessment and early identification of newborns potentially at risk for neurodevelopmental concerns.