<p>Background: The purpose of the study was to evaluate the use of contingent prenatal screening for the detection of Down&rsquo;s syndrome and neural tube defects (NTDs) in west of Iran.<br /> Methods: A prospective study was conducted on 653 pregnant women referred to a medical diagnostic laboratory (Imam Reza Clinic, Kermanshah, Iran) for contingent prenatal screening tests between October 2016 to September 2017.&nbsp;<br /> Results: Among 651 women screened in the first trimester, 8 (1.22%) pregnancies were screen-positive for Down&rsquo;s syndrome. In the second trimester, among 605 women, 25 (4.13%) had a positive result and all of these women voluntarily underwent amniocentesis. Overall, five pregnancies were complicated with chromosomal abnormalities, including five cases of Down&rsquo;s syndrome.&nbsp;<br /> Conclusion: In a nutshell, the contingent prenatal screening tests were found to be useful for estimation of Down&rsquo;s syndrome as well as NTDs in both young and older mothers in west of Iran. These tests should be performed for pregnant women before an invasive test for Down&rsquo;s syndrome.</p>