J Reprod Infert arij001 Journal of Reproduction & Infertility 2228-5482 2251-676X Avicenna Research Institute jri60056 Fertility Preservation in Benign Gynecological Diseases: Current Approaches and Future Perspectives SleimanZakiLebanese American University, Department of Obstetrics and Gynecology, Beirut, LebanonKaramanErbilDepartment of Obstetrics and Gynecology, Medical Faculty, Yuzuncu Yil University, Van, TurkeyTerzicMilanDepartment of Obstetrics and Gynecology, National Research Center of Mother and Child Health, University Medical Center, Astana, TurkeyDepartment of Medicine, Nazarbayev University, School of Medicine, Astana, KazakhstanDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USATerzicSanjaDepartment of Medicine, Nazarbayev University, School of Medicine, Astana, KazakhstanFalzoneGiovanniObstetrics and Gynaecology Unit, Umberto I Hospital, Enna, ItalyGarzonSimoneDepartment of Obstetrics and Gynecology, Filippo Del Ponte Hospital, University of Insubria, Varese, Italy 20 4 201 209 26 3 2019 17 7 2019

<p>Although fertility preservation is a growing topic in the management of oncological diseases, different benign gynecological pathologies are able to compromise the ovarian reserve due to mechanisms related to the pathology itself or secondary to the performed treatments. Endometriosis, benign ovarian tumors, adnexal torsion, familiarity and genetic syndromes are all benign conditions that can compromise the ovarian reserve. Endometriosis and particularly endometriomas provide a direct damage to ovarian reserve, with different mechanisms, and an indirect damage related to surgery. Similarly, benign ovarian tumors can provide a detrimental effect on ovarian reserve for the surgical treatment, especially for bilateral or recurrent tumors, and in case of secondary adnexal torsion with late diagnosis. Different fertility preservation options are available and should be considered particularly in cases with bilateral or recurrent pathology and/or surgery. In general, the identification of patients at risk of early ovarian failure, for benign gynecological disease or based on known genetic causes or familiarity, is of paramount importance in order to apply fertility preservation techniques before the complete depletion of ovarian reserve.</p>