J Reprod Infert arij001 Journal of Reproduction & Infertility 2228-5482 2251-676X Avicenna Research Institute jri80079 Rare Disorder of Sexual Differentiation with a Mosaic 46,XX/47,XXY in a Klinefelter Syndrome Individual PattamshettyPreethiDepartment of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Hyderabad, IndiaMantriHarikaDepartment of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Hyderabad, IndiaMohanVasaviDepartment of Genetics and Molecular Medicine, Vasavi Medical and Research Centre, Hyderabad, India 21 3 222 225 27 12 2019 12 4 2020

<p>Background: Klinefelter syndrome (KS) mosaicism 46,XX/47,XXY is an extremely rare disorder of sex development characterized by the presence of both ovarian and testicular tissues in the same individual. Both elements can be present in the same gonad (ovotestis) or separately in the same individual or as a unilateral ovotestis and the other side with testis or ovary. A mosaic with 46,XY would present with problems related to male infertility and in general, testicular insufficiency, but with a 46,XX mosaic, it is a completely rare presentation. As adolescents, these boys may experience severe emotional and behavioral issues; it is up to the parents to identify these conditions early and get them physician evaluated for possible abnormalities so that they can get the benefit of treatment.&nbsp;<br /> Case Presentation: A case of a rare disorder of sexual differentiation with a mosaic 46,XX/47,XXY in a KS individual is reported for whom karyotyping and SRY-FISH work-up was done.&nbsp;<br /> Conclusion: Early cytogenetic testing is essential to identify these individuals and testosterone replacement therapy and breast reduction for case management are helpful. Assisted reproductive technology (ART) may assist these individuals father children in some cases.&nbsp;</p>