- Parvaneh Mirabe
- - M.Sc. Student, International Branch, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
- Mahrokh Dolatian
 - 1- Department of Midwifery, International Branch, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
- 2- Department of Midwifery, Faculty of Nursing and Midwifery, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
- Faraz Mojab
- - Department of Pharmacogenosy, Faculty of pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
- Hamid Alavimajd
- - Department of Biostatistics, Faculty of Paramedical, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Received: 8/12/2009 Accepted: 11/22/2009 - Publisher : Avicenna Research Institute |
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Abstract
Introduction: Primary dysmenorrhea refers to painful cramps during menstruation with no organic origin. Regarding the high prevalence of dysmenorrhea and its adverse effects on the quality of life of sufferers and the evidence on sedative and antispasmodic properties of Valerian officinalis on smooth muscles, this double-blind clinical trial was conducted to determine the effects of the herb on the severity of dysmenorrheal symptoms in Zanjan Islamic Azad University students during 2009. Materials & Methods: The subjects included 100 students who were matched for dysmenorrheal severity, age, menarche onset, body mass index (BMI), duration, interval and amount of bleeding as well as occupation and educational achievements of their parents. The subjects were randomly divided into experimental (49 subjects) and control (51 subjects) groups. The experimental group took 255mg capsules of the herb, three times a day for three days at the onset of menses while the controls similarly took placebo (capsules containing starch). Pain severity was evaluated by a visual analogue scale (0 to 10cm) and systemic manifestations by a multidimensional verbal scale before and during two consecutive menstrual cycles. The severity and duration of symptoms were analyzed and compared between the two groups. Results: There were no significant differences in pain severity between the two groups before the intervention. However, pain severity was reduced in both groups after the intervention (p<0.001 ) with significantly more relieving results in the experimental group (p<0.05). in addition, the total scores for systemic manifestations associated with dysmenorrhea, insignificantly decreased in both groups, except occurrence of syncope (p<0.05). conclusion: valeriana officinalis decreased dysmenorrheal symptoms, which it might be attributed to its antispasmodic effects. further studies are warranted for the use of valerian officinalis in decreasing dysmenorrheal symptoms.< pan>
Keywords:
Dysmenorrheal pain, Primary dysmenorrhea, Spasm, Valeriana officinalis, Visual analogue pain scale To cite this article:References
- French L. Dysmenorrhea. Am Fam Physician. 2005; 71(2):285-91. [PubMed]
- Speroff L, Fritz MA. Clinical gynecologic endocrinology and infertility. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. Chapter 14, Dysmenorrhea; p. 539.
- Berek JS, Novak E. Novak’s Gynecology. 14th ed. Philadelphia: Lippincott Williams & Wilkins; 2007. Chapter 29, Dysmenorrhera; p. 516.
- Agarwal A, Venkat A. Questionnaire study on men-strual disorders in adolescent girls in Singapore. J Pediatr Adolesc Gynecol. 2009;22(6):365-71. [PubMed]
- Singh A, Kiran D, Singh H, Nel B, Singh P, Tiwari P. Prevalence and severity of dysmenorrhea: a problem related to menstruation, among first and second year female medical students. Indian J Physiol Pharmacol. 2008;52(4):389-97. [PubMed]
- Loto OM, Adewumi TA, Adewuya AO. Prevalence and correlates of dysmenorrhea among Nigerian college women. Aust N Z J Obstet Gynaecol. 2008; 48(4):442-4. [PubMed]
- Poureslami M, Amin E, Sarmast H. [Assessment of knowledge ,attitudes, and behaviour of adolescent girls in suburban districts of Tehran regarding dysmenorrhea and menstrual hygiene]. J Shaheed Sadoughi Univ Med Sci. 2001;9(Suppl 4):S23-30. Persian. [Abstract]
- Panahande Z, Pakzad Z, Ashoori R. [Survey the prevalence, knowledge and practice of Gilan univer-sity students about dysmenorrheal]. J Gilan Univ Med Sci. 2007;17(2):87-94. Persian. [Abstract]
- Noroozi A, Tahmasebi R. [Pattern of menstruction, hirsutism and dysmenorrhea in students of Boushehr Medical and Khalig-e-Fars universities (2002-2003)]. Med J Hormozgan Univ. 2004;7(4):203-9. Persian. [PubMed]
- Hsu CS, Yang JK, Yang LL. Effect of a dysmenor-rhea Chinese medicinal prescription on uterus contractility in vitro. Phytother Res. 2003;17(7): 778-83. [PubMed]
- Neville F, Hacker J, Moore G. Essentials of obstetrics and gynecology . 4th ed. Malek Mohammadi S, Arian Mehr S, Ghaem Maghami F, translator. Tehran: Teymour zadeh & Tabib; 2004. p. 290.
- DeCherney AH, Nathan L. Current obstetric & gynecologic diagnosis & treatment. 9th ed. New Yourk: McGraw-Hill Professional; c2003. Chapter 3, Dysmenorrhea; p. 625.
- Ebadi M. Pharmacodynamic basis of herbal medicine. 1st ed.London: CRC Press; 2001. Chapter 58, Valerian for sleep disorders; p. 938.
- Samsam Shariat H. Collection of medicinal herbs. 1st ed. Tehran: Char Bagh; 2007. p. 938.
- DerMarderosian A, Beutler JA. The review of natural products: the most complete source of natural product information. 1st ed. Philadelphia: Facts and Comparisons; 2001. p. 609.
- Mills S, Bone K. The essential guide to herbal safety. 1st ed. Philadelphia: Elsevier Health Sciences; 2005. p. 616.
- Braun L, Cohen M. Herbs & natural supplements: an evidence-based guide. 1st ed. Sydney: Elsevier Australia; 2005. p. 373.
- Thomson Healthcare (Firm). PDR for herbal medicines. 3rd ed. Montvale: Thomson; 2004. p. 852.
- Barnes J, Anderson LA, Phillipson JD, Newall CA. Herbal medicines: a guide for healthcare professionals. 2nd ed. London: Pharmaceutical Press; 2002. p. 468.
- de Smet P. Adverse effects of herbal drugs. 1st ed. Tafaghodi M, Amiri R, Hossein zadeh H, translator. Mashhad: Mashhad University of Medical Sciences; 2006. p. 220.
- Hadley S, Petry JJ. Valerian. Am Fam Physician. 2003;67(8):1755-8. Review. [PubMed]
- de Smet P. Adverse effects of herbal drugs. 2nd ed. Vol. 3. Valeriana. Michigan: Springer-Verlag; c1997. p. 210.
- Gilani AH, Khan AU, Jabeen Q, Subhan F, Ghafar R. Antispasmodic and blood pressure lowering effects of Valeriana wallichii are mediated through K+ channel activation. J Ethnopharmacol. 2005; 100(3):347-52. [PubMed]
- Beckmann CR, Barzansky BM, Herbert WN. Obstetrics and Gynecology. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 205.
- Amanzadeh Y. Herbal Pharmacopoeia. 1st ed. Tehran: Food and Drug Department of the Ministry of Health and Medical Education; 2003. p. 456.
- Occhiuto F, Pino A, Palumbo DR, Samperi S, De Pasquale R, Sturlese E, et al. Relaxing effects of Valeriana officinalis extracts on isolated human non-pregnant uterine muscle. J Pharm Pharmacol. 2009;61(2):251-6. [PubMed]
- Andreatini R, Sartori VA, Seabra ML, Leite JR. Effect of valepotriates (valerian extract) in generalized anxiety disorder: a randomized placebo-controlled pilot study. Phytother Res. 2002;16(7): 650-4. [PubMed]
- Circosta C, De Pasquale R, Samperi S, Pino A, Occhiuto. Biological and analytical characterization of two extracts from Valeriana officinalis. J Ethnopharmacol. 2007;112(2):361-7. [PubMed]
- Roozbahani N, Jabbari Z, Yazdi S. [The compari-son of Shirazi Thymus Vulgaris and Mefenamic acid effects on primary dysmenorrhea]. J Arak Univ Med Sci. 2005;8(3):1-6. Persian. [Abstract]
- Torkzahrani Sh, Akhavan-Amjadi M, Mojab F, Alavi Majd H. [Clinical effects of Foeniculum vulgare extract on primary dysmenorrheal]. J Reprod Infertil. 2007;8(1):45-51. Persian. [Abstract]
- Shahraz S, Ghaziani T. Generic Pharmacopoeia of Iran. 1st ed. Tehran: Teymourzadeh. 2004. p. 51.