Farid Abolhasani Corresponding Author
- Endocrinology and Metabolism Research Center (EMRC), Tehran University of Medical Sciences, Tehran, Iran
Mojgan Mohammadi
- Endocrinology and Metabolism Research Center (EMRC), Tehran University of Medical Sciences, Tehran, Iran
Akbar Soltani
- Endocrinology and Metabolism Research Center (EMRC), Tehran University of Medical Sciences, Tehran, Iran

Received: 1/1/2005 Accepted: 1/1/2005 - Publisher : Avicenna Research Institute

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Introduction: Osteoporosis is the most common metabolic bone disease. In addition to morbidity, osteoporotic fractures also increase mortality risk in affected patients. Enough evidence is not available to indicate that, like western countries, osteoporosis is a public health problem in Iran. Therefore EMRC planned to estimate the burden of osteoporotic fractures in year 2001 based on existing sources of data. The EMRC study on bone density, the MOH study on unintentional injuries, and international literature on mortality risk following osteoporotic fractures were the main sources of information used for this study. Materials and Methods: To estimate burden of osteoporotic fractures, the prevalence of osteoporosis, the incidence of osteoporotic fractures, and the relative risk of mortality following these fractures were approximated. The mean duration of disability following major osteoporotic fractures was estimated through epidemiologic modeling. Assumptions on the disability weights of morbid conditions resulting from osteoporotic fractures were made through comparing these conditions with similar ones in Global Burden of Disease Study. Based on mortality and incidence rates, mean durations of disability, and disability weights; the DALYs indicator was calculated for Spine, Hip, and Forearm fractures. Results: In women hip, spine, and forearm fractures were responsible for 15880, 1269, and 121 mortality- and morbidity-related lost years of life respectively. Similar figures in men were 16495, 2225, and 37 years. Collectively osteoporosis deprived Iranian population from 36026 healthy years of life (18757 in men and 17270 in women) in 2001. Higher burden of osteoporosis in men, mainly results from higher risk of mortality following fractures in male sex. Conclusion: The national study on unintentional injuries indicates that the incidence of osteopor-otic hip fractures in Iranian population is much less than other populations. Higher bone mineral density and other probable differences between Iranians and other populations that affect fracture risk, like environmental conditions and life style, should be investigated as probable determinants of this difference. Limited available sources of information regarding osteoporotic fractures necessitate more comprehensive studies to clarify all aspects of this health problem.

Keywords: Osteoporosis, Burden of osteoporosis, Bone fracture

To cite this article:


  1. World Health Organization. How Is the Public Interest Protected, in World Health Report 2000; Health Systems: Improving Performance.2000; P:117.
  2. World Health Organization. Health Services: Well Chosen, Well Organized?, in World Health Report 2000; Health Systems: Improving Perfor-mance. 2000;P:47.
  3. National Osteoporosis Foundation, Osteoporo-sis: Review of the Evidence for Prevention, Diagnosis, Treatment and Cost-effectiveness Analysis- 1998, Osteoporos Int.1998;(Suppl4):S7-S8.
  4. Johnell O., Kanis J.A., Oden A., Sernbo I., Redlund- Johnel I., Petterson C., De Laet C., Jon-sson B. Mortality after osteoporotic fractures. Osteoporos Int.2004;15:38-42.
  5. Forsen L., Sogaard A. J., Meyer H.E., Edna T. H., Kopjar B. Survival after Hip Fracture: Short- and Long-term Excess Mortality According to Age and Gender. Osteoporos Int.1999;10:73-78.
  6. Hasserius R., Karlsson M.K., Nilsson B.E., Redlund-Johnell I., Johnell O. Prevalent vertebral deformities predict increased mortality and increa-sed fracture rate in both men and women: A 10 year Population-based Study of 528 Individuals from Swedish Cohort in European Vertebral Osteoporosis Study. Osteoporos Int.2003;14:61-8.
  7. Kanis J. A. et al, The burden of osteoporotic fracture: A method for setting intervention thresh-olds. Osteoporos Int.2001;12:417-27.
  8. Trombeti A., Herrmann F., Hoffmeyer P., Schurch M.A., Bonjour J.P., Rizzoli R. Survival and Potential years of life lost after hip fracture in men and age-matched women. Osteoporos Int. 2002;13:731-37.
  9. Krappweis J., Rentsch A., Schwarz U.I., Kro-bot K.J., Kirch W. Outpatient Costs of osteo-porosis in a National Health Insurance Population. Clin Therap.1999;21:2001-14.
  10. مطالع? بار ملي بيماري‌ها، وزارت بهداشت، درمان و آموزش پزشكي.
  11. Murray C.J.L., Acharya A.K., Understanding DALYs. J Health Economics.1997;16:703-30.
  12. Mathers C.D., Vos T., Lopez A.D., Salomon J., Ezzati M. (Edition), Disease Modeling Using DisMod, in National Burden of Disease Studies: A Practical Guide. Edition 2.0 Chapter 8 P: 64. Global Program on Evidence for Health Policy. Geneva: World Health Organization Oct.2001.
  13. لاريجاني باقر، سلطاني اكبر، پژوهي محمد، باستان حق محمد حسن. تغييرات تراكم معدني استخوان در افراد 20-69 ساله‌اي ساكن تهران. طب جنوب. سال پنجم، شمارة 1،صفحات 41-49.
  14. نقوي محسن، جعفري ناهيد، علاء الديني فرشيد، دلاوري عليرضا. اپيدميولوژي حوادث غير عمدي در ايران در سال 1382. وزارت بهداشت درمان و آموزش پزشكي، معاونت سلامت، دبيرخان? تحقيقات كاربردي. (منتشر نشده است)
  15. Cummings S. R., Melton L.J. Epidemiology and Outcomes of Osteoporotic Fractures. Lancet. 2002;359: 1761-7.
  16. Salomon J.L. Health State Valuation in Summary Measures of Population Health, in Murray C. J. L. and Evans D. (ed.), Health System Performance Assessment, World Health Orga-nization, 2003.
  17. GBD 90 Disability Weights and DALYs Calculation Template. These can be found in WHO website:http://www3.who.int/whosis/menu. cfm? path= evidence, burden, burden_ manual_ other & language= english
  18. نقوي محسن، جمشيدي حميد رضا، بهره‌مندي از خدمات بهداشتي درماني در جمهوري اسلامي ايران در سال 1381، وزارت بهداشت درمان و آموزش پزشكي 1383 (در دست انتشار).
  19. Sanders K. M. Age- and Gender-Specific rate of fractures in Australia: A population-based study. Osteoporosis Int.1999;10:240-47.
  20. Kanis J.A., Johnell O., Oden A., Sernbo I., Redlund-Johnell I., Dawson A., De Laet C., Jon-sson B. Long-term risk of osteoporotic fracture in Malmo. Osteoporosis Int.2000;11:669-74.
  21. Memon A. Incidence of hip fracture in Kuwait. Int J Epidemiol.1998;27:860-65.
  22. Lau E.M.C., Lee J. K., Suriwongpaisal P., Saw S. M., Das De S., Khir A., Sambrook P. Inci-dence of hip fracture in four asian countries: The Asian osteoporosis study (AOS). Osteoporosis Int.2000;12:239-43.
  23. Memon A., Pospula W.W., Tantawy A.Y., Abdul-Ghafar S., Suresh A., Al-Rowaih A. Incid-ence of Hip fracture in Kuwait. Int J Epidemiol. 1998;27:860-65.
  24. Koh L.K. H., Saw S. M., Lee J.J.M., Leong K., Lee J. Hip fracture rates in Singapore.1991-1998, Osteoporos Int.2000;12:311-18.
  25. Iki M., Kagamimori S., Kagawa Y., Matsu-zaki T., Yoneshima H., Marumo F. Bone Mineral Density of the Spine, Hip and Distal Forearm in Representative Sample of Japanese Female Pop-ulation: Japanese Population –Based Osteoporosis (JPOS) Study. Osteoporos Int.2001;12:529-37.
  26. Woo J., Li M., Lau E. Population Bone Mineral Density Measurement for Chinese Wom-en and Men in Hong Kong. Osteoporos Int.2001; 12:289-95.
  27. Tenenhouse A., Joseph L., Kreiger N., Poli-quin S., Murray T. M., Blondeau L., Berger C., Hanley D.A., Prior J.C. Estimation of the Pre-valence of Low Bone Density in Canadian Women and Men Using a Population- Specific DXA Reference Standard: The Canadian Multice-nter Osteoporosis Study (CaMos). Osteoporos Int. 2000;11:897-904.


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