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Alieh Tourabizadeh Corresponding Author
- Department of Obs. & Gyn., Ghaem Hospital, Faculty of Medicine, Mashad University of Medical Sciences and Health Services, Mashad, Iran
Fatemeh Vahidrodsari
- Department of Obs. & Gyn., Ghaem Hospital, Faculty of Medicine, Mashad University of Medical Sciences and Health Services, Mashad, Iran

Received: 7/1/2005 Accepted: 7/1/2005 - Publisher : Avicenna Research Institute

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Abstract

Introduction: Hypogonadotropic amenorrhea is one kind of primary amenorrhea which is caused by a decrease in GnRH secretion and results in infertility. As infertility is an important problem in 10-15% of couples, the present study was undertaken to determine the prevalence of the disease in infertile women and pregnancy rates in response to its treatment. Materials and Methods: This cross-sectional, analytical study included 35 subjects suffering from hypothalamic amenorrhea, pulled from 2150 patients who referred to the infertility center of Montaserieh Hospital in Mashad during 2000-2002. The gathered data included: the patients age, infertility duration, menstrual cycles, history of prior surgeries or illnesses, food regimens and drug history. A gynecologic exam, hormonal assays and sonographic evaluations were carried out. The patients underwent 3 cycles of ovulation induction procedures. A serum -hCG measurement and a vaginal sonography were used to confirm pregnancy. The data were analyzed by SPSS 11. For the descriptive analysis, t-test and logistic regression were used and the significance level was considered 5% (p<0.05 ). results: the patients aged 20-35 and their infertility period varied from 1.5 to 14 years. three of them were excluded from the study because of loss to follow up. the prevalence rate was 1-6%. in all of the patients, the serum fsh and lh levels were <5iu l. serum prolactin levels were 21.7% 34.8 iu l and tsh 1.20.6 iu l. 14 patients out of 32, responded to treatment and became pregnant after three cycles of treatment (43.7%). conclusion: the prevalence rate of infertility due to hypogonadotropic amenorrhea in this study was 0.016. infertility due to hypogonadotropic amenorrhea is a disease that can respond to common ovulation induction treatment schedules quite well and despite the short period of treatment (3 cycles) in this study, 43.7% of the patients became pregnant. it is expected that by increasing the treatment period, better results will follow as it has in studies following 6 cycles of treatment with 83-90.1% success rates.< pan>


Keywords: Primary amenorrhea, Hypogonadotropic, Infertility, Gonadotropin, Human menopausal genadotropin, Prolactin, Intrauterin insemination


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