JRI 
Vol. 1, Issue 1, / January-March 2000
(Original Article, pages 31-35)

Mehri Ghafourian Boroujerdnia Corresponding Author
- Department of Immunology, Ahwaz Medical Science University, Ahvaz, Iran

Received: 1/10/2000 Accepted: 3/1/2000 - Publisher : Avicenna Research Institute

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Abstract

Introduction: Introduction: Leucocytes accounted for 26-36% of the stromal cells in decidua of the first trimester of gestation in which 75% of them is related to endometrial granulated lymphocytes (eGL) with an unusual natural killer (NK) cell-like phenotype. Different roles are proposed for eGL, but fundamental role of these cells in control for normrly underestood. Material and Methods: In this study immunosuppressive activity of supernatants prepared from ten sample of normal first trimester decidua which cultured into cell suspension and corresponding purified eGL were investigated using. PHA-induced lymphoproliferation assay. Results: The results showed that although supernatants from purified 24 hours eGL at 50% concentration tended to show increased immunosuppressive activity compared with the corresponding unfractionated cell suspension supernatants, the results did not reach significance.. Conclusion: It seems eGL can mediate immunosuppression activeity in human uterus, but whether this activity is crucial for survival of feto-placental unit real pregnancy is not cleare. more investigation in pathological pregnancy.



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References

  1. Bulmer J.N., Morrison L., Longfellow M., and Ritson A. (1991). Leukocytes in human deciduas: Investigation of surface markers and function, Colloque INSERM, 212:189-196.
  2. Starkey P.M., Sargent I.L., and Redman C.W.G. (1988) Cell populations in human early pregnancy deciduas; Characterizion and isolation of lymphocytes by folwcytometry large granular Immunology, 65:129-134.
  3. Bulmer J.N., Morrison L., Longefellow M., Ritson A., and Pace D. (1991). Granulatedlymphocytes in human endometrium: histochemical and immunohistochemical studies, Hum. Reprod., 6:791-798.
  4. Stewart I.J., (1991). Granulated metrial gland cells: pregnancy specific leukocytes J., Leuk Biol, 50:198-207.
  5. King A., Birkby I.L., Starkey P.M., and Redman, C.W. (1991). Cytotoxic activity against trophoblastand choriocarcinoma cells of large granular lymphocytes from human early pregnancy deciduas, Cell Immunol, 132:140-149.
  6. Clark D.A., Vince G., Flanders K.C., Hirte H., and Starkey P. (1994). CD 56 lymphoid cells inhuman first trimester pregnancy deciduas as a source of novel transforminggrowthfactor-b2- relate dimmuno-suppressive factor, Hum. Reprod., 9:2277.
  7. Nakayama E., Asono S., Kodo and Miwa, S.J., (1985). Suppression of the mixed lymphocyte Reaction by cells human first pregnancy endometrium., J Reprod. Immunol. 8:25-31.
  8. Ghafourian Boroujernia M., and Bulmer J.N., (1995). Immunosuppression in the human uterus, Immunology, 89 (Suppl.1), 157.
  9. Haller H., Gudelj L., Rubesa G., Petrovic O., and Rukavina D. (1993). Suppressive effect ofdecidual leucocytes, periodicum Biologorum, 95:327:333.
  10. Chaouoat G., Tranchot-Diallo J., Volumenie J.L., Menu E., (1997). Immune suppression and Th1/Th2 balance in pregnancy revised. Am J. Repord. Immunol., 37(6):427-34.
  11. Daya S., Rosenthal K.L., and Clark D.A. (1987) Immunosuppressor factor (s) produced bydecidua-associated suppressor cell: a proposed mechanism for fetal allograft survival, Am. J. Obs & Gyn. 156: 344-350.
  12. Lea R.G., Underwood J., Falanders K.C., Hirte H., Banwatt D., Finotto S., Ohno I., Daya S., Harley C. Michel M., Mowbray J.F., and Clark D.A.(1995). A subset of patients with recurrent spontaneous abortion is transforming growth factor b2-production by “suppressor cells” in uterine tissue near the placental attachment site A.J., Reprod Immunol. 34:52-64.

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