Fatemeh Vahidrodsari
1- Department of Obstetrics and Gynecology, Ghaem Hospital, Mashad University of Medical Sciences, Mashad, Iran
2- Research Center for Women’s Health, Mashad University of Medical Sciences, Mashad, Iran
Sedigheh Ayaty Corresponding Author
1- Department of Obstetrics and Gynecology, Ghaem Hospital, Mashad University of Medical Sciences, Mashad, Iran
2- Research Center for Women’s Health, Mashad University of Medical Sciences, Mashad, Iran
Alieh Tourabizadeh
1- Department of Obs. & Gyn., Ghaem Hospital, Faculty of Medicine, Mashad University of Medical Sciences and Health Services, Mashad, Iran
2- Research Center for Women’s Health, Mashad University of Medical Sciences, Mashad, Iran
Hossein Ayat-Allahi
- Department of Hematology, Ghaem Hospital, Mashad University of Medical Sciences, Mashad, Iran
Habibollah Esmaeli
- Biostatistics Center, Department of Community Medicine, Ghaem Hospital, Mashad University of Medical Sciences, Mashad, Iran
Masoud Shahabian
1- Department of Obstetrics and Gynecology, Ghaem Hospital, Mashad University of Medical Sciences, Mashad, Iran
2- Cardiovascular Research Center, Mashad University of Medical Sciences, Mashad, Iran

Received: 9/29/2007 Accepted: 6/15/2008 - Publisher : Avicenna Research Institute

Related Articles


Other Format



Introduction: Preeclampsia is a common gestational disorder which complicates 5-8% of pregnancies and it is associated with maternal, fetal and neonatal morbidity and mortality. Alterations in serum calcium (Ca) and magnesium (Mg) levels have been suggested as effective factors in causing preeclampsia. This study was conducted to compare serum calcium and magnesium levels in preeclamptic and normal pregnant women.Materials and Methods: In this case-control study, 50 preeclamptic and 50 normal pregnant women referring to Ghaem Hospital, affiliated to Mashad University of Medical Sciences, were selected during 2005. Blood samples of both groups with similar gestational ages were collected and compared for calcium and magnesium concentrations. The data were analyzed by student t-test, 2, Kolmogorov-Smirnov, Fishers exact tests and a general linear model.Results: The demographic data in the two groups, had no significant difference (P<0.01 ) but there was a significant difference between them in terms of smoking history (p<0.05). serum magnesium levels in the preeclamptic women were significantly lower than those of individuals with normal pregnancy (1.920.37 mg l vs. 2.290.69 mg l), (p<0.01) while calcium levels had no significant differences (9.160.75mg l vs. 9.471.58 mg l).conclusion: this study revealed that serum magnesium level in preeclampsia is lower than that of the normal pregnant women. this result may support the hypothesis on the role of magnesium deficiency in preeclampsia pathophysiology and suggest the usefulness of its assessment in the early diagnosis of the disorder.< pan>

Keywords: Calcium, Magnesium, Preeclampsia, Pregnancy, Prenatal care

To cite this article:

Figures, Charts, Tables


  1. Cuningham FG, Levano KJ, Bloom SL, Hauch JC, Gilstrap LC, Wenstrom KD. Williams Obstetrics. 22nd Edition. New York: Mc Graw. Hill. 2005;pp:762-8.
  2. Sibia BM. Gabbe SG, Niebyl JR, Simpson JL. Hyper-tension. In: Obsterics: Normal and Problem of Pregnan-cies: New York: Churchill livingstone. 2002; pp:639-65.
  3. Aali S, Khazaeli P, Ghasemi F, Mehdizadeh A. Serum magnesium and calcium ions in patients with sever preeclampsia undergoing magnesium sulfate therapy. Med Sci Monit. 2007;13(4):191-4.   [PubMed]
  4. Eftekhari N, Salari Z. [The comparison of total and ionized serum calcium level in preeclamptic pregnant women and the women with normal pregnancy]. J Rafsanjan University Med Sci.2005;4(2):123-8. Persian.
  5. Kosch M, Hausberg M, Louwen F, Barenbrock M, Rahn KH, Kisters K. Alterations of plasma calcium and intracellular and membrane calcium in erythrocytes of patients with preeclampsia. J Hum Hypertens. 2000; 14(5):333-6.   [PubMed]
  6. Kisters K, Barenbrock MG, Louwen F, Hausberg M, Rahn KH, Kosch M. Membrane, intracellular and plasma magnesium and calcium concentration in preec-lampsia. Am J Hypertens. 2000;13(7):765-9.   [PubMed]
  7. Kanchapan S, Vorapong P.Serum calcium and magne-sium in normal and preeclmaptic pregnancy. Arch Gynecol Obstet. 2005;273:12-6.   [PubMed]
  8. Punthumapol C, Kittichotpanich B. Serum calcium, magnesium and uric acid in preeclampsia and normal pregnancy. J Med Assoc Thai. 2008;91(7):968-73.   [PubMed]
  9. Omu AE, Al-Harmi A, Vedi HL, Mlchkova L, Sayed AF, Al-Raqum NS. Magnesium sulphate therapy in women with pre-eclampsia and eclampsia in Kuwait. 2008;17(3):227-32.   [PubMed]
  10. Niromanesh S, Laghaii S, Mosavi-Jarrahi A. Supple-mentary calcium in prevention of preeclampsia. int J Gyneacol Obstet. 2001;74(1):17-21.   [PubMed]
  11. Malas NO, Shurideh ZM. Does serum calcium in pre-eclampsia and normal pregnancy differ?. Saudi Med J. 2001;22(10):868-71.   [PubMed]
  12. More C, Bhattoa HP, Bettembuk P, Balogh A. The effects of pregnancy and lactation on hormonal status and biochemical markers of bone tumorer. Eur J Obstet Gyencol Reprod Biol. 2003;106:209-13.   [PubMed]
  13. Ritchie LD, Fung EB, Halloran BP, Turnlund JR , Van Loan MD, Cann CE, King JC .A longitudinal study of calcium homeostasis during human pregnancy and lactation and after resumption of menses. Am J Clin Nutr. 1998;67:693-701.   [PubMed]
  14. Power ML, Heaney RP, Kalkwarf HJ, Pitkin RM, Repke JT, Tsang RC, Schulkin J. The role of calcium in health and disease. Am J Obstet Gyencol. 1999;181: 1560-9.   [PubMed]
  15. Richards SR, Nelson DM, Zuspan FP. Calcium levels in normal and hypertensive pregnant patients.Am J Obstet Gyencol. 1984;149:168-71.   [PubMed]
  16. Pedersen EB, Johannesen P, Kristensen S, Rasmussen AB, Emmertsen K, Moller J, Lauritsen JG, Wohlert M. Calcium, parathyroid hormone and calcitonin in normal prengnacy and preeclmapsia. Gyencol Obstet Invest. 1984;18:156-64.   [PubMed]
  17. Sanders R, Konijnenberg A, Huijgen HJ, Wolf H, Boer K, Sanders GT. Intracellular and extracellular, ionized and total magnesium in pre-eclampsia and uncompli-cated pregnancy. Clin Chem Lab Med. 1999;37:55-9.   [PubMed]
  18. Frenkerl Y, Weiss M, Shefi M, Lusky A, Mashiach S, Dolev E. Mononuclear cell magnesium content remains unchanged in various hypertensive disorders of preg-nancy. Gynecol Obstet Invest. 1994;38:220-2.   [PubMed]
  19. Handwerker SM, Altura BT, Altura BM. Ionized serum magnesium and potassium levels in pregnant women with preeclampsia and eclampsia. J Reprod Med. 1995;40:201-8.   [PubMed]
  20. Kulier R, De Dnis M, Culmezoglu AM, Villavj Natritional interventions for the prevention of maternal morbidity. Int J Gynaecol Obstet. 63:231-46.   [PubMed]
  21. Roberts JM, Balk JL, Bodnar LM, Belizan JM, Bergel E, Martinez A. Nutrient involvement in preeclmapsia. J Nutr. 2003;133:1684s-92S.   [PubMed]
  22. Touyz RM. Role of magnesium in the pathogenesis of hypertension. Mol Aspects Med. 2003;54:107-36.   [PubMed]


Home | About Us | Current Issue | Past Issues | Submit a Manuscript | Instructions for Authors | Subscribe | Search | Contact Us

"Journal of Reproduction & Infertility" is owned, published, and managed by Avicenna Research Institute .
Creative Commons License

This work is licensed under a Creative Commons Attribution –NonCommercial 4.0 International License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

Journal of Reproductoin and Infertility (JRI) is a member of COMMITTEE ON PUBLICATION ETHICS . Verify here .

©2024 - eISSN : 2251-676X, ISSN : 2228-5482, For any comments and questions please contact us.