Vol. 2, Issue 1, / January-March 2001
(Review Article, pages 68-74)

Leili Chamani Tabriz Corresponding Author
- Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Received: 11/15/2000 Accepted: 3/8/2001 - Publisher : Avicenna Research Institute

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Chlamydia trachomatis infection is the most common sexually transmitted disease all around the world. For a long time, Chlamydia trachomatis has been recognized as the common cause of urethritis, cervicitis, and other complications such as pelvic inflammatory disease (PID), ectopic pregnancy, etc. However, today there is more concern on its role in male and female fertility and infertility and many studies have concentrated on this issue all over the world. There is good evidence based on seroepidemiologic studies on relationship between serum Chlamydial antibodies and infertility due to tubal factor in women with or without PID. However, there are many questions about Chlamydia trachomatis and its influence on IVF outcome and the exsisting information is controversial. The impact of Chlamydia trachomatis on male infetility is under investigation and it seems able to cause destruction of different parts of male genital tract in addition to high rate of transmission to women. With regard to these data, it seems that prevention, early diagnosis and treatment of Chlamydial infections are importart and cost effective.

Keywords: Chlamydia trachomatis, Fertility, Infertility, Infeetion, Pelvic Inflammatory

To cite this article:


  1. Gerbase A.C., Rowley J.T., Mertens T.E. Global epidemiology of sexually transmitted disease. Lancet, 1998; 35(Suppl.III). 52-55
  2. Chachter S.J. Chlamydial infections (in three parts). N.Engl J. Med. 1978; 298:428-435;490-495,540-549
  3. Sulova A., Strimiskova J., Pilda L., et al. Direct and indirect detection of chlamydia in infertile married couples in the assisted reproductive program
  4. Deborah Josefson. Chlamydia increases risk of cervial cancer. BMJ. 2001; 322:71
  5. Paa vonen J., Eggert kruse W. Chlamydia trachomatis: impact on human reproduction. Hum Reprod Update. 1999; 5(5): 433-47
  6. Beatty W.L., Morrison R.P., Byrne G.I. Persistent chlamydiae: from cell culture to a paradigm for chlamyclial pathogenesis. Microbiol. Rev. 1994; 58:686-99
  7. Black C.M. Current methods of laboratory diagnosis of chlamydia trachomatis infection. Clin. Microbiol Rev. 1997; 10:160-84
  8. Puolakkainen M., Hiltunen Back E., Reunala T., et al. Comparison of performances of two commercially available tests, a PCR assay and a ligase chain reaction test, in detection of urogenital chlamydia trachomatis infection. J. Clin Microbiol 1998; 36:1489-93
  9. Osteggard L. Diagnosis of urogenital Chlamydia trachomatis infection by use of DNA amplification. APMIS. 1999; 107 (suppl.89) 1-36
  10. Jedi Tehrani M. Diagnostic Methods of clamydia Trachomatis. Med J Reprod Infertil 2000; 1(9): 36-43
  11. Brunham R.C., Paavonen J., Stevens C. Mucopurulent cervicitis- the ignored counterpart of urethritis in men. N.Eng J. Med. 1984; 158:510-17
  12. World Health Organization. Infections, pregnancies, and infertility: Perspectives on prevention. Fertil Steril. 1987; 47:964-8
  13. Eckert L.O., Hawes S.E., Wolner Hanssen P. Prevalence and correlates of antibody to chlamydial heat shock protein in women attending sexually transmitted disease clinics and women with confirmed pelvic inflammatory disease. J Infect. Dis. 1997;175:1453-8
  14. Sziller I., Wikkin S.S., Ziegert M., et al. Serological responses of patients with ectopic pregnancy to epitopes of the Chlamydia trachomatis 60 kDa heat shak protein. Hum Reprod. 1998;13:1088-93
  15. Claman P., Amimi M.N., Peeling R.W. Does serologic evidence of remote Chlamydia trachomatis infection and its heat shock protein (hsp60) affect in vitro fertilization-embryo transfer outcome? Fertil Steril. 1996; 65:146-9
  16. Spandorfer S.D., Neuer A., La verda D., et al. Previously undetected chlamydia trachomatis infection, immunity to heat shock proteins and tubal occlusion in women undergoing in vitro fertilization. Hum Reprod. 1999;14(1):60-4
  17. Gaudoin M., Rekha P., Morris A., et al. Baterial vaginosis and past chlamydial infection are strongly and independently associated with tubal infertility but do not affect in vitro fertilization success rates. Steril Fertil. 1999; 72(4):2
  18. Witkin S.S., Kligman I., Grifo J.A., et al. Chlamydia trachomatis detected by polymerase chain reaction in cervices of culture – negative women correlates with adverse in vitro fertilization outcome. J Infect Dis. 1995;171(6):1657-9
  19. Witkin S.S., Immunity to heat shock proteins and pregnancy outcome. Infec Dis Obs Gyn. 1999;7(1-2):35-8
  20. Keay S.D., Barlow R., Eley A., et al. The relation between immunoglobolin G antibodies to chlamydia trachomatis and poor ovarian response to gonadotropin stimmulation before IVF. Fertil Steril. 1998;70 (2):214-8
  21. Neuer A., Spandorfer S.D., Giraldo P., et al. The role of heat shocke protein in reproduction. Hum Reprod Update. 2000;6(2):149-59
  22. Shararara F.I., Qveenan J.T Jr., Springer R.S., et al. Elevated serum Chlamydia trachomatis IgG antibodies. What do they mean for IVF pregnancy rates and loss? J Reprod Med. 1997; 42(5):281-6
  23. Wollenhaupt J., Kolbus F., weibbrodt H. Manifestations of urogenital chlamydial infection. Clin Exp Rheumatol. 1995; 13:453-45
  24. Wolner H.P., Mardh P.A. In vitro tests of the adherence of chlamydia trachomatis to human spermatozoa. Fertil Steril. 1984; 42:102-7
  25. Fribery J., Confino E., Suares M., et al. Chlamydia trachomatis attached to spermatozoa recovered from the peritoneal cavity of patients with salpingitis. J Reprod Med. 1987; 32:120-2
  26. Nagel T.C., Tagatz G.E., Campbell B. Transmission of chlamydia trachomatis by artificial insemination. Steril Fertil. 1986; 46:959-60
  27. Berger R.E. Acute epididymitis. In: Holmes K.K, Marth P.A, Sparling P.F. Sexually Transmitted Diseases 2th edn McGraw Hill, New York. 1990; pp:641-52
  28. Wikin S.S., Kligman I., Bongiovanni A.M. Relationship between of asymptomatic male genital tract exposure to chlamydia trachomatis and an autoimmunic response to spermatozoa. Hum Reprod. 1995; 10:2952-5
  29. Munoz M.G., Jeremias J., Witkin S.S. The 60 kDa heat shock protein in human semen: relationship with antibodies to spermatozoa and chlamydin trachomatis. Hum Reprod. 1996;11:2600-3
  30. Aurouk M.R., de Mouy D.M., Acar J.F. Male fertility and chlamydial serology, a study of 61 fertile and 82 subfertile men. J Androl. 1987;8:197-200
  31. Torode H.W., Wheeler R.A., Sannders D.M., et al. The role of chlamydial antibodies in an in vitro fertilization program. Fertil Steril. 1987;48:987-90
  32. Centers for Disease Control and Prevention guidelines for treatment of sexually transmitted diseases. MMWR. 1998; 47,PR-1
  33. Rakita, R.M. Intracellular activity, potential clinical uses of antibodies. ASM News, 64:570-5


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