JRI 

Bita Mohammadi
- Midwifery Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Lida Moghaddam Banaem Corresponding Author
- Midwifery Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Mohammad Asghari jafar-abadi
- Department of Statistic & Epidemiology Faculty of Health & Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran

Received: 10/21/2009 Accepted: 2/17/2010 - Publisher : Avicenna Research Institute

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Abstract

Introduction: Preeclampsia is one of the most common medical complications during pregnancy that can be a major cause of prenatal morbidity and mortality. One of the most studied biomarkers in the prediction of preeclampsia is C-reactive protein. The objective of this study was to assess the relationship between maternal serum CRP concentrations in early pregnancy and the onset of preeclampsia during the gestational period. Materials and Methods: In this prospective cohort study, serum CRP levels were measured in 400 pregnant women in their 20th week of gestation. They were all followed up till delivery. The data were finally analyzed statistically. Results: After controlling for the effects of maternal age (< 19 and > 35 years), multiple regression analysis for primiparity, supplementary calcium intake, BMI and CRP depicted a statistically significant relationship between CRP levels and mild (OR = 1.71, 95% CI = 1.39 - 2.11) and severe (OR = 2.45, 95% CI = 1.80-3.34) preeclampsia onsets. Among all the aforementioned variables, only supplementary calcium intake was significantly effective in the prevention of preeclampsia. In ROC curve analysis, the CRP cut-off point in moderate preeclampsia was 5.35 mg/l (with 94% sensitivity and 81% specificity), and in severe preeclampsia it was 5.45 mg/l (with 94.4% sensitivity and 82.5% specificity). Conclusion: It seems that CRP can help identify pregnant women who are at high risks of preeclampsia but larger studies are needed to establish a definitive relationship.


Keywords: Calcium supplementation, C-reactive protein, Inflammation, Preeclampsia, Pregnancy


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References

  1. Ghomian N. [investigation of duration of activity phase and method delivery in primipar with preeclampsia]. Raze Behzistan. 2003;10(4):6-9. Persian.
  2. Hwang HS, Kwon JK, Kim MA, Park YW. Maternal serum highly sensitive C-reactive protein in normal pregnancy and pre-eclampsia. Am J Obstet Gynecol. 2007;98:105-9.   [PubMed]
  3. Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol. 2003;102(1):181-92. Review.   [PubMed]
  4. Wang Y, Gu Y, Zhang Y, Lewis DF. Evidence of endothelial dysfunction in preeclampsia: decreased endothelial nitric oxide synthase expression is associated with increased cell permeability in endothelial cells from preeclampsia. Am J Obstet Gynecol. 2004;190(3):817-24.   [PubMed]
  5. Kupferminc MJ, Peaceman AM, Aderka D, Wallach D, Socol ML. Soluble tumor necrosis factor receptors and interleukin-6 levels in patients with severe preeclampsia. Obstet Gynecol. 1996;88(3):420-7.   [PubMed]
  6. Ridker PM, Glynn RJ, Hennekens CH. C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction. Circulation. 1998;97(20):2007-11.   [PubMed]
  7. Tillett WS, Francis Jr T. Serological reactions in pneumonia with a non-protein somatic fraction of pneumococcus. J Exp Med. 1930;52(4):561–71.   [PubMed]
  8. Tjoa ML, van Vugt JM, Go AT, Blankenstein MA, Oudejans CB, van Wijk IJ. Elevated C-reactive protein levels during first trimester of pregnancy are indicative of preeclampsia and intrauterine growth restriction. J Reprod Immunol. 2003;59(1):29-37.   [PubMed]
  9. Malek A, Bersinger NA, Di Santo S, Mueller MD, Sager R, Schneider H, et al. C-reactive protein production in term human placental tissue. Placenta. 2006;27(6-7):619-25.   [PubMed]
  10. Beigi A, Saeedi L, Samiei H, Zarrinkoub F, Zarrinkoub H. [Elevated CRP levels during first trimester of pregnancy and subsequent preeclampsia: a prospective study]. Tehran Univ Med J. 2008;66(1): 25-8. Persian.   [Abstract]
  11. Beigi A, Saeedi L, Samiei H, Zarrinkoub F, Zarrinkoub H. [Elevated CRP levels during first trimester of pregnancy and subsequent preeclampsia: a prospective study]. Tehran Univ Med J. 2008;66(1): 25-8. Persian.   [Abstract]
  12. Ayatollahi H, Hasanzade M, Farzadnia M, Khabbaz Khoob M, Rahmanian A. Serum Level of High Sensitive C-Reactive Protein in Normal and Preeclamptic Pregnancies. Iran J Pathology. 2007;3 (2):100-4.   [Abstract]
  13. Savvidou MD, Lees CC, Parra M, Hingorani AD, Nicolaides KH. Levels of C-reactive protein in pregnant women who subsequently develop preeclampsia. BJOG. 2002;109(3):297-301.   [PubMed]
  14. Djurovic S, Clausen T, Wergeland R, Brosstad F, Berg K, Henriksen T. Absence of enhanced systemic inflammatory response at 18 weeks of gestation in women with subsequent pre-eclampsia. BJOG. 2002;109(7):759-64.   [PubMed]
  15. Wolf M, Kettyle E, Sandler L, Ecker JL, Roberts J, Thadhani R. Obesity and preeclampsia: the potential role of inflammation. Obstet Gynecol. 2001;98(5 Pt 1):757-62.   [PubMed]
  16. Qiu C, Luthy DA, Zhang C, Walsh SW, Leisenring WM, Williams MA. A prospective study of maternal serum C-reactive protein concentrations and risk of preeclampsia. Am J Hypertens. 2004;17(2): 154-60.   [PubMed]
  17. Roberts JM. Preventing pre-eclampsia. Lancet. 1996;348(9023):281-2.   [PubMed]
  18. Hubel CA. Oxidative stress in the pathogenesis of preeclampsia. Proc Soc Exp Biol Med. 1999;222 (3):222-35.   [PubMed]
  19. Ranjkesh F. [Comparison of 24h urin Cu level in preeclampsia women with normal pregnant and normal non pregnant] [master's thesis]. [Tehran]: Tarbiat Modares University; 2005. Persian.
  20. Cuningham FG, Gant NF, Leveno KJ, Gilstrap III LC, Hauth JC, Wenstrom KD. Williams obstetrics. 21st ed. New York: Mc Graw-Hill; 2001. p. 568-9.
  21. Kumar A, Devi SG, Batra S, Singh C, Shukla DK. Calcium supplementation for the prevention of preeclampsia. Int J Gynaecol Obstet. 2009;104(1):32-6.   [PubMed]
  22. Yoon BH, Jun JK, Park KH, Syn HC, Gomez R, Romero R. Serum C-reactive protein, white blood cell count, and amniotic fluid white blood cell count in women with preterm premature rupture of membranes. Obstet Gynecol. 1996;88(6):1034-40.   [PubMed]
  23. Redman CW, Sacks GP, Sargent IL. Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol. 1999;180(2 Pt 1):499-506. Review.   [PubMed]

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