Dear Editor, The paper entitled “Attitude of Male and Female Subjects towards Oocyte Donation in Shiraz” published in the Journal of Reproduction and Infertility in Spring 10[1 (38)]:51-57 is valuable research but seems to have a few methodological flaws that could have affected the results of the paper: 1. The questionnaire used in the paper has been described to be “Researcher-devised” and does not seem to be a standard one and nothing has been mentioned about how it has been designed or what the validation procedure has been. More-over, the questions seem not to be cohesively related resulting in a smaller internal validity. 2. Apparently, we cannot rely on the judgment and attitude of a group of people who have not accepted the donation itself and deliberated on “anonymity between donor and the resulting child”, “preferring adoption to donation” and“ children belong to the parents”. When people do not agree with something, they cannot express positive ideas about it. 3. Referring to the holy Quran to prove parent-hood seems to be inappropriate because there is disagreement among high-ranking clergies on this subject and all seem to have their own reasons and proofs. Even if a high-ranking religious figure “Marja taghlid” issues a decree or “fatwa”, it is to be obeyed only by his own followers. There-fore, without complete discussion and presentation of all the proofs and ideas, it is not ethically acceptable to use a religious decision which is controversial itself. 4. At the end of the paper, it is mentioned that people’s attitude toward egg donation has positive relationship with their educational level, but no statistical values have been presented.