Vol. 20, Issue 2, / April-June 2019
(Commentary, pages 115-117)
PMID: 31058057 (PubMed) - PMCID: PMC6486565

Amani Ahmed
- Caen University Hospital, Caen, France
Muaweah Ahmad Alsaleh Corresponding Author
- CesamS-CERReV, and INSERM, University of Caen Normandy, Caen, France

Received: 10/6/2018 Accepted: 1/25/2019 - Publisher : Avicenna Research Institute

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In evolutionary theories (Lamarckian and Darwinian), environment and physical changes could be transmitted to the descendants (1). Psychological factors in human beings (2–4) have a negative impact on the germ cells parameters (5). As time goes on, the quality of sperm is deteriorating (5, 6) as well as humanoocyte/egg (7).
A simple change of environment and environmental preconceptional exposure (i.e., diet, physical activity, smoking, alcohol consumption, etc.) affects the functioning of the genes and the phenotype of the next generation through remodeling epigenetic blueprint of spermatozoa (8, 9). Lifestyle and environmental factors influence the sperm and egg which will affect subsequent generations (10–12). Some studies have examined the transmission of specific behavioral and structural adaptations in relation to the stimulus in the nervous system, from parents to their offspring (10, 13).
Effects of psychological and environmental factors on gene expression persist even after the removal of the inducing agent passed on to subsequent generations (14). So, Genetic Memory can be contemplated in two ways (Biology and Psychology) (10, 15). 
Psychological factors which have the impact on fertility are treated in numerous studies on humans (5, 16–18) as psychological stress (7). The life of wars and prisons has an effect on germ cells (Sperm, menstrual irregularity and reproductive function) (7, 19, 20). Men who suffered from anxiety and depression or who have experienced high levels of stress had long-term sperm damage. Stress affects sperm quality over the long term, even slowing down the mental development of offspring. This stress is transmitted from one generation to another and has other perverse effects (21). 
Sperm of obese men have a distinct epigenetic signature compared to lean men. The methylome of spermatozoa is dynamically remodeled after weight loss (22). Paternal nutritional status can directly affect the health of offspring (21, 23), suggesting that an epigenetic inheritance phenomenon acquired by the environment is transmitted by gametes (22). Environmental factors as exercise and nutritional status induce acute changes in DNA methylation profiles in human skeletal muscle and adipose tissue (24–28) demonstrating that environmental factors are reshaping the epigenome of somatic tissues (22). 
The fertility of humans is impacted by myriad factors (Stress, obesity, alcohol and tobacco, seasonal variations, etc.) (28, 30). "Licking" (31), sense of touch and massage can be a great stress reliever, and is very important to emotional health (32), and sexual desire and performance (33). Scientists have found that the process of "Traumatic stress, etc." can be reversed if mice from traumatized lineages are put in "Enriched" environments (34). Psychotherapy could improve psychological and environmental factors and make the environment more positive and richer (35).   
Scientists have reached several conclusions by researching humans; the trauma would thus modify the behavior of the traumatized individual but also those of his descendants since one finds a metabolic modification until the third generation. This would mean that trauma also affects germ cells (Spermatozoa and ova) which are the only biological link between generations (34). A positive and nurturing environment help humans withstand the threat (34, 36). The decrease in anxiety (37), improvement of psychological factors (38) with reduced vulnerability to stress factor and shocks (39) are related to bgetting a pregnancy (5). 
Negative psychological and environmental factors, war, nutritional status, seasonal variations, physical and social environmental factors and stress have many negative consequences and effects on the germ cells. "Enriched" and positive environments can reverse these factors and have positive consequences on the germ cells in individual that could be transmitted to their off spring.

The author would like to thank Mr. Ahmad Alsaleh and Mrs. Sabrié Alsaleh, Dr. Ameni Ahmed, and Mrs. Régine Fabien for their participation in giving the counseling.

Conflict of Interest
The author declares that he has no competing interest. Author has not received the financial support for research.


  1. Lamarck J. Influence des circonstances sur les ac-tions des animaux (5e leçon). Muséum National d’Histoire Naturelle de Paris. 1810;
  2. Brkovich AM, Fisher WA. Psychological distress and infertility: forty years of research. J Psychosom Ob-stet Gynaecol. 1998;19(4):218-28.   [PubMed]
  3. Vellani E, Colasante A, Mamazza L, Minasi MG, Greco E, Bevilacqua A. Association of state and trait anxiety to semen quality of in vitro fertilization patients: a controlled study. Fertil Steril. 2013;99(6):1565-72.   [PubMed]
  4. Wright J, Duchesne C, Sabourin S, Bissonnette F, Benoit J, Girard Y. Psychosocial distress and infertil-ity: men and women respond differently. Fertil Steril. 1991;55(1):100‑8.   [PubMed]
  5. Zorn B, Virant-klun I, Kolbezen M, Velikonja V, Meden-Vrtovec H. Facteurs de stress psychologique et qualité du sperme dans une population de 450 hommes infertiles slovènes. Andrologie. 2001;11(2):76‑85.
  6. Auger J, Kunstmann JM, Czyglik F, Jouannet P. Decline in semen quality among fertile men in Paris during the past 20 years. N Engl J Med. 1995;332(5):281‑5.   [PubMed]
  7. Abu-Musa AA, Kobeissi L, Hannoun AB, Inhorn MC. Effect of war on fertility: a review of the litera-ture. Reprod Biomed Online. 2008;17 Suppl 1:43‑53.   [PubMed]
  8. Donkin I, Barrès R. Sperm epigenetics and influence of environmental factors. Mol Metab. 2018;14:1-11.   [PubMed]
  9. Jablonka E, Lamb MJ. Evolution in four dimen-sions: genetic, epigenetic, behavioral, and symbolic variation in the history of life. 1st ed. Cambridge, Mass: MIT Press; 2005. 462 p.
  10. Namazi H. Can we explain the memory transfer between generations by mathematical analysis of DNA walk? ARC J Neurosci. 2017;2(2):1-3.
  11. Dias BG, Ressler KJ. Parental olfactory experience influences behavior and neural structure in subse-quent generations. Nat Neurosci. 2014;17(1):89-96.   [PubMed]
  12. Lim JP, Brunet A. Bridging the transgenerational gap with epigenetic memory. Trends Genet TIG. 2013;29(3):176‑86.   [PubMed]
  13. Stickrod G, Kimble DP, Smotherman WP. In utero taste/odor aversion conditioning in the rat. Physiol Behav. 1982;28(1):5‑7.   [PubMed]
  14. Turner BM. Epigenetic responses to environmental change and their evolutionary implications. Philos Trans R Soc B Biol Sci. 2009;364(1534):3403‑18.   [PubMed]
  15. Gallistel R, Pashler H. Learning, motivation, and emotion. 3rd ed. New York, NY: Wiley; 2002. 900 p.
  16. Bigelow PL, Jarrell J, Young MR, Keefe TJ, Love EJ. Association of semen quality and occupational factors: comparison of case-control analysis and analysis of continuous variables. Fertil Steril. 1998;69(1):11‑8.   [PubMed]
  17. Gerhard I, Lenhard K, Eggert-Kruse W, Runne-baum B. Clinical data which influence semen pa-rameters in infertile men. Hum Reprod Oxf Engl. 1992;7(6):830‑7.   [PubMed]
  18. Giblin PT, Poland ML, Moghissi KS, Ager JW, Ol-son JM. Effects of stress and characteristic adapt-ability on semen quality in healthy men. Fertil Steril. 1988;49(1):127‑32.   [PubMed]
  19. Bass F. [L’amenorrhée au camp de concentration de Terezin (Theresienstadt)]. Gynaecologia. 1947;123(4):211‑9. [Article in Undetermined Language].
  20. Whitacre FE, Barrera B, Briones TN. WAR amen-orrhea: a clinical and clinical laboratory study. J Am Med Assoc. 1944;124(7):399-403.
  21. Rodgers AB, Morgan CP, Bronson SL, Revello S, Bale TL. Paternal stress exposure alters sperm mi-croRNA content and reprograms offspring HPA stress axis regulation. J Neurosci. 2013;33(21):9003‑12.   [PubMed]
  22. Donkin I, Versteyhe S, Ingerslev LR, Qian K, Mechta M, Nordkap L, et al. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell Metab. 2016;23(2):369‑78.   [PubMed]
  23. Marsit CJ. Influence of environmental exposure on human epigenetic regulation. J Exp Biol. 2015;218( Pt 1):71-9.   [PubMed]
  24. Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of depression. Neuron. 2002;34(1):13‑25.   [PubMed]
  25. Walker E, Mittal V, Tessner K. Stress and the hy-pothalamic pituitary adrenal axis in the develop-mental course of schizophrenia. Annu Rev Clin Psychol. 2008;4:189‑216.   [PubMed]
  26. Brown AS. The environment and susceptibility to schizophrenia. Prog Neurobiol. 2011;93(1):23‑58.   [PubMed]
  27. Hultman CM, Sandin S, Levine SZ, Lichtenstein P, Reichenberg A. Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies. Mol Psychiatry. 2011;16(12):1203‑12.   [PubMed]
  28. Patterson PH. Maternal infection and immune involvement in autism. Trends Mol Med. 2011;17(7):389‑94.   [PubMed]
  29. Levitas E, Lunenfeld E, Weisz N, Friger M, Har-Vardi I. Seasonal variations of human sperm cells among 6455 semen samples: a plausible explana-tion of a seasonal birth pattern. Am J Obstet Gy-necol. 2013;208(5):406.e1-6.   [PubMed]
  30. Hall E, Burt VK. Male fertility: psychiatric consid-erations. Fertil Steril. 2012;97(2):434‑9.   [PubMed]
  31. Weaver IC, Cervoni N, Champagne FA, D’Alessio AC, Sharma S, Seckl JR, et al. Epigenetic pro-gramming by mternal behavior. Nat Neurosci. 2004;7(8):847‑54.   [PubMed]
  32. Scott E. Could Sex be Used as a Stress Manage-ment Technique? [Internet]. Verywell Mind. 2018 [cité 2 juill 2018]. Disponible sur: https://www.verywellmind.com/sex-as-a-stress-management-technique-3144601
  33. Bendas J, Georgiadis JR, Ritschel G, Olausson H, Weidner K, Croy I. C-Tactile mediated erotic touch perception relates to sexual desire and perfor-mance in a gender-specific way. J Sex Med. 2017;14(5):645‑53.   [PubMed]
  34. Mansuy I. TRAUMATISMES EN HÉRITAGE, UNE APPROCHE PAR L’ÉPIGÉNÉTIQUE. Cité des Sciences et de l’Industrie-conférence [Internet]. 2014; Disponible sur: https://bienheureusement.fr/traumatismes-en-heritage-une-approche-par-epigenetique/
  35. Alsaleh M, Lebreuilly R, Tostain M, Lebreuilly J. La puissance des répétitions des phrases des pensées positives (RPPP): un outil efficace de traitement contre les troubles psychologiques (dé-pression, anxiété et stress). Une étude pilote con-trôlée et randomisée. Ann Méd Psychol Rev Psy-chiatr. 2018;176(5):388-447.
  36. Alsaleh M, Kubitary A. Verdicts of water drop-sTRPPT on brain and life new frontiers in neuro cognitive positive psychotherapy in war and peace, normal-abnormal-medical-non-medical conditions. 1st ed. (Place of Publication????): Édi-tions universitaires européennes; 2017. 92 p.
  37. Harlow CR, Fahy UM, Talbot WM, Wardle PG, Hull MG. Stress and stress-related hormones during in-vitro fertilization treatment. Hum Reprod. 1996;11(2):274‑9.   [PubMed]
  38. Sanders KA, Bruce NW. A prospective study of psychosocial stress and fertility in women. Hum Reprod. 1997;12(10):2324‑9.   [PubMed]
  39. Facchinetti F, Matteo ML, Artini GP, Volpe A, Genazzani AR. An increased vulnerability to stress is associated with a poor outcome of in vitro ferti-lization-embryo transfer treatment. Fertil Steril. févr 1997;67(2):309‑14.   [PubMed]


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