Ashraf Amirzargar Corresponding Author
- Physiology Department, Faculty of Medicine, Ahwaz Medical Sciences University, Ahvaz, Iran

Received: 7/1/2002 Accepted: 7/1/2002 - Publisher : Avicenna Research Institute

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Soluble salts of Barium are widely used in industry but their intake orally causes acute toxicity. Their spread in work environment can cause several complications such as painful contractions of visceral smooth muscles. Aim of this study is to evaluate effect of Barium Chloride on muscle contractility of isolated uterus of rabbit. For this purpose, 1-2 cm of Newzeland rabbit’s uterus (1300-2300 g) was mounted in organ bath. Bath contained tyrod solution (pH=7.4, 370 C) gassed with 95% O2 and 5% CO2. Changes of rabbit uterus contraction in response to different concentration of Barium were recorded by a polygraph using an isometric transducer. The results indicate that Barium chloride can cause significant contraction in the uterus in a dose dependent manner. Probably Barium Chloride exerts its effect by affecting Ca channels depending to voltage or blocking K channels, but knowing the mechanism of action needs more studies. In conclusion abortive effect of BaCL2 in uterus and abortion in human and animals must be considered particularly when it is consumed.

Keywords: Barium Chloride, Uterus, Rabbit, Infertility, Smooth muscle, Abortion

To cite this article:


  1. عباسي همايون. چكيده مقالات سمينار عوامل محيطي و ناباروري: بررسي توزيع فراواني شغل مردان نابارور مراجعه كننده به مركز ناباروري اصفهان ارديبهشت تا پايان تيرماه79. تهران، پژوهشكده ابن‏سينا، سال 1380، ص: 18.
  2. Tarasenko N. Y., Pronin D.A., Silayev A.A. Barium compounds as industrial poisons (an experimental study). J Hyg Eepidemid Microbiol Immunol. 1977; 1: 361- 73.
  3. Dare P.R.M., Hewitt P.J., Hicks R. Barium in welding. Ann Accup Hyg. 1984; 28:445- 8.
  4. Hemmati A.A., Hicks R. A quantitative study of the effects of inhaled barium in guinea pig. Proceeding of British pharmaceutical society. 1996; 13- 6.
  5. Andrew B. Experimental physiology. 9th Edition. Great Britain, Churchill Livigstone, London. 1972; 46- 53.
  6. Ghai L. Practical physiology. 4th Editioin. Vashist printing service. Delhi vij, 110053 tender. Jaypee brothers Medical publishers. 1987.
  7. Reynolds J.E., Martindale the extra pharmacopia. 13th Edition. Royal pharmaceutical society, London. 1996; 1006- 678.
  8. Gosselin R., Smuth R., Hodge H. Clinical toxicalogy of commercial products. 5th Edition. Williams and Wilkins, London. 1981; 11- 62.
  9. Klaassen C.D., Amdur M.O., Doull J. Casarett and Doulls toxicology, the basic stance of poisons. 5thEdition. Mc Graw-Hill companies, New York. 1996; 726- 996.
  10. Rastogi S.C., Pritzl G. Red Lipstick: a source of barium to humans and the environment. Bull Environ Contam Toxicol. 1998; 60: 507- 10.
  11. Ellenhorn M.J. Ellenhorn’s medical toxicology: diagnosis and treatment of human poisoning. 2nd Edition.Williams and Wilkins, London. 1990; 1129.
  12. چراغ فاتن. بررسي اثر كلريد باريم بر روي ايلئوم جداشده موش صحرائي. پايان نامه دكتراي داروسازي. دانشگاه علوم پزشكي اهواز، سال 1378، ص: 3.
  13. Cuthbert N. J., Gadiner P.J., Kash K., et al. Roles of calcium influx and intracellular calcium release in agonist induced contractions in guinea pig trachea. Am J Physiol. 1994; 266: 620-7.
  14. Zang W.J., Boyett M.R. Barium block of the muscarinic potassium current in guinea pig a trial cells.Pflugers Arch. 1995; 430: 348-57.
  15. Gillis A.M. Geonzon R.A., Mathison H.J., et al. The effects of barium, dofetilide and 4-aminopyridine (4-Ap) on ventricula repolarization in normal and hypertrophied rabbit heart. J Pharmacol Exp Ther. 1998; 285(1): 2262- 70.
  16. Sohma Y., Harris A., Argent B.E., et al. Anovel type of internal barium block of a maxi –k-channel from human vas deferens epithelial cells Biophys J. 1998; 74: 199-209.
  17. Bllatner R., Classen H. G., Dehnert H., et al. Experiments on isolated smoot muscle preparations.Hugstetten, HSE biological measuring techniques Germany. 1980; 134- 41.
  18. مطاعي محمود. اثر آلومينيوم بر فعاليت انقباضي رحم ايزوله موش صحرايي. دانشگاه علوم پزشكي اهواز، سال ‌1376، ص: 10-107، 27-26، 12.
  19. Ebadi M. A review with questions and explanations pharmacology. 2nd Edition. Little Brown and company, London. 1992; 409- 13.
  20. Goodman Gliman A., Hardman J., Limbird L.E., et al. The pharmacological basis of therapeutics. 9Th Edition. Mc Graw-Hill, London. 1996; 273: 771- 6.
  21. Yamamoto T., Effects of estrogens on channels in myometrial cells isolated from pregnant rats. AM J Physiol. 1995; 268(1): 64-9.
  22. Mershon J.L., Mikala G., Schwartz A. Changes in the expression of the L type voltage dependent calcium channel during pregnancy and parturition in the rat. Biol Reprod. 1994; 51(5): 993- 9.
  23. Kawarabayashi T. Effects of external calcium, magnesium and temperature on spontaneous contractions of pregnant human myometrium. Biol Reprod. 1989; 40: 942- 8.
  24. هاشمي مسعود. فيزيولوژي توليد مثل و تلقيح مصنوعي. تهران،‌ انتشارات فرهنگ جامع، سال1370، ‌ص: 91-87.
  25. Kyozuka M., Collins S. M., Crankshaaw J., et al. Calcium and contraction smooth muscle cells from rat myometrium. Can J physiol Pharmacol. 1987; 57:1966- 75.


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