- Hedayat Sahraei
 - - Department of Physiology and Biophysics, Faculty of Medicine, Baghyatallah (a.s.) Medical Sciences University, Tehran, Iran
- Gholamreza Kaka
- - Anatomy Department, Faculty of Medicine, Baghyatallah (a.s.) Medical Sciences University, Tehran, Iran
- Hasan Ghoshooni
- - Department of Physiology and Biophysics, Faculty of Medicine, Baghyatallah (a.s.) Medical Sciences University, Tehran, Iran
- Maryam Shams Lahijani
- - Biology Department, Faculty of Sciences, Beheshti University, Tehran, Iran
- Mina Ramezani
- - Biology Department, Faculty of Sciences, Azad University, Tehran, Iran
Received: 7/1/2002 Accepted: 7/1/2002 - Publisher : Avicenna Research Institute |
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Abstract
In addition to have side effects on adults and embryos, abused drugs by affective sex and hypophysial hormones can reduce germ cells and sexual drive resulting infertility in human. Aim of this study is to evaluate the effects of addiction to morphine-induced infertility in Balb/c mice. For these purpose, a control (n=6) and 21 experimental (n=363) groups were used. Then oral morphine with initial doses (0.01, 0.05 and 0.1 mg/ml of water) in a 3 weeks period was administered to the animals and then the animals were crossed to each other. On 17th day of pregnancy, female rats were anesthetized by ether and the embryos were taken out surgically. Results showed that in all groups the birth chance were reduced according to the control group. The reduction was observed in group, which was treated with 0.01 morphine. Therefore it is concluded that morphine extremely reduced the birth chance in mice and may reduce fertility in animals and this may be reliable for human.
Keywords:
Morphine, Mice, Infertility, Abused durgs, Addiction To cite this article:References
- Koop G. F., Le Moal M. Drug addiction, dysregulation of reward, and allostasis. Neuropsycho Pharmacol. 2001; 24(2): 97- 129.
- Siddiqui A., Haq S., Shah B.H. Prenatal exposure to morphine disrupts brain norepinephrine, ovarian cyclicity and sexual respectivity in rats. Pharmacol Biochem Behav. 1997; 58(1): 243- 8.
- Akabori A., Barralough C.A., Effects of morphine on luteinizing hormone secretion and catecholamine turnover in the hypothalamus of estrogen treated rats. Brain Res. 1986; 36(2): 221- 6.
- Zagon I.S., Mclaughlin P.J. Morphine and brain growth retardation in the rat. Pharmacol. 1977; 15(3): 276- 82.
- Zagon I.S., Mclaughlin P.J. Effect of chronic morphine administration on pregnant rats and their offspring.Pharmacol. 1977; 15(4): 302-10.
- Badaway A.A., Evans M. Rapid reversal by naloxone of the chronic effects of morphine on liver and tryptophan brain metabolism. Br J Pharmacol. 1981; 74(3): 511- 3.
- Lal P., Rajeshwari-Devi R. K. Effect of chronic naloxone and morphine treatments on testicular, body weight and plumage pigmentation cycle. Lal Munia. Estrilba Amandava, Gen Comp End. 1997; 107: 2- 11.
- Yilmaz B., Konar V. Influence of chronic morphine exposure on serum LH, FSH, testostrone levels and body and testicular weights in the developing mail rats. Archives of Andrology. 1999; 43: 189- 96.
- Williams J.T., Christie M.J., Manzoni O. Cellular and synaptic adaptations mediating opioid dependence.Physiol Rev. 2001; 81(1): 299- 343.
- Ross E.M. In: Goodman Gilman A., Rall T.W., Nies A.S., Taylor P. The pharmacological basis of theraputics. 8th Eddition, Pergamon Press, New York. 1991; pp 33- 48.
- Kalra S.P. Opioid adrenergic steriod connections in regulation of luteinizing hormone secretion in the rat. 1984; 38(5): 418- 26.
- Johnson J.H., Rosecrans J.A. Blockade of ovulation by methadone in the rat: a central nervous system mediated acute effect. Pharmacol J Exp Ther. 1980; 213(1): 110- 3.
- Sheridan P.J., Buchanan J.M. The effects of opiate on androgen binding in the forebrain of the rat. Int J Fertil. 1980; 25(1): 36- 43.