Mohsen Maddah Corresponding Author
- Nutrition Department, Faculty of Public Health, Guilan University of Medical Sciences, Rasht, Iran
Abolghasem Jazayery
- Human Nutrition and Biochemistry Department, Faculty of Public Health, Tehran Medical Sciences University, Tehran, Iran
Reyhan Mirdamadi
- Department of Obstetric and Midwifery, Faculty of Medical Sciences, Tarbyat Modarress University, Tehran, Iran
Mohammad Reza Eshraghiyan
- Epidemiology Department, Faculty of Publi Health, Tehran Medical Sciences University, Tehran, Iran

Received: 10/1/2002 Accepted: 10/1/2002 - Publisher : Avicenna Research Institute

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Central obesity is an important cause of hyperlipidemia, hypertension, diabetes mellitus and coronary heart disease. The relationship between sex hormones, especially androgens, and body fat distribution in women is controversial. This study investigated the relationship between sex hormones, such as total testosterone DHEA-S, LH, FSH, esteradiol and insulin, with Body Mass Index (BMI) and Waist to Hip Ratio (WHR) in 176 women with age: 25.8±6.0 years (18-43) and BMI: 27.3±4.4 (17-51 kg/m2). Serum level of sex hormones including total testosterone, estradiol, FSH, LH, Dehydroepiandrosterone Sulfate (DHEA-S) were measured by radio immuno assay. Our findings showed that WHR was positively correlated with serum level of testosterone (r=0.15, P=0.05) and it was negatively related to serum level of estradiol (r=-0.1, P=0.05). Sex hormone concentrations were not different in obese and normal weight women, but women with central obesity (WHR>0.85) had significantly higher levels of testosterone (2.4±0.7 vs 2.1±0.7 nmol/L, P=0.001) and lower levels of serum estradiol (24.1±8.7 vs 57.6±14.5 pmol/L, P=0.009) than women with low WHR (WHR<0.85 ). in conclusion, these data showed that high serum testosterone and low serum estradiol levels were associated with upper body fat distribution in women. serum level of estradiol versus testosterone possibly affects body fat distribution in women.< pan>

Keywords: BMI, Testosterone, Estradiol, Central Obesity, Sex hormone, Waist to Hip Ratio

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  1. Chumlea W.C., Guo S.S. Assessment and prevalence of obesity. Endocrine. 2000;13:135- 42.
  2. Bjorntorp P. Portal tissue as a generator of cardiovascular disease and diabetes. Arteriosclerosis. 1990;10:493-6.
  3. Hubert H.B., Feinleib M., McNamar P.M., Smith A. Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framinghan Heart Study. Circulation. 1983;67:986-77.
  4. Kissebah A.H., Krakowar G.R. Regional adiposity and mortality. Physiol Rev. 1994; 74:781-811.
  5. Haffner S.M. Sex hormones, obesity, fat distribution, type2 diabetes and insulinresistance:Epidemiological and clinical corrlation. Int J Obs. 2000;24:56-8.
  6. Armellini F., Zamboni M., Castelli S., Robbi R., Mino A., Todesco T., Bergamo-Andreis I.A., Bosello O.Interrelationship between intraabdominal fat and total serum testosterone levels in obese women. Metab. 1994;43:390-5.
  7. Kirschner M.A., Samojlik E., Drejka M., Fachensik J. Androgen-estrogen metabolism in women with upper body fat versus lower body fat obesity. J Clin Endocrinol Metab. 1990;70:
  8. Hauner H., Ditschuneit H.H., Pal S.B., Moncayo R., Pfeiffer E.F. Fat distribution, endocrine and metabolic profile in obese women with and without hirsutism. Metab. 1988;37:281-6.
  9. World Health Organization (WHO) Expert Committee. Physical Status: The use and interpretation of anthropometry. Technical Report Series no. 854. WHO: Geneva, 1995.
  10. Xu X., De Pergola G., Bjorntorp P. The effect of androgens on the regulation of lipolysis in adipose precursor cells. Epidemiol. 1990; 126:1229-34.
  11. Rebuffe-Scrive M., Lonnroth P., Marin P. Regional adipose tissue metabolism in men and post-menopausal women. Int J Obs. 1987;11:347-55.
  12. Ivandic A., Prepic-Krizevac I., Sucic M., Juric M. Hyperinsulinemia and sex hormones in healthy premenopausal women: Relative contribution of obesity, obesity type and duration of obesity.Metab. 1988;47:13-9.
  13. Evans D.J., Hoffman R.G., Kalkhoff R.K., Strain B. Relationship of androgenic activity to body fat topography, fat cell morphology, and metabolic aberration in premenopausal women. J Clin Endocrinol.Metab. 1983;57:304-10.
  14. Ivandic A., Prpic-Krizevac I, Bozic D., Barbir A., Peljhan V., Balag A., Glanovic M. Insulin resistance and androgens in healthy women with different body fat distribution. Wien Klin Wochenschr. 2002;114(8-9):321-6.
  15. Goodman-Gruen D., Barrett-Connor E. Total but not bioavailable testosterone is a predictor of central adiposity in postmenopausal women. Int J Obs. 1995;19:293-8.
  16. Garaulel M., Perex-Liamas F., Funete T., Zamora S., Tebar F.J. Anthropometric, computed tomography and fat cell data in an obese population: relationship with insulin, leptin, tumor necrosis factor, sex hormone-binding globulin and sex hormones. Eur J Endocrinol. 2002;5:657-66.
  17. Barbieri R.L., Makris A., Randall R.W. Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J Clin Endocrinol Metab 1986;62:904-10.
  18. Zumoff B. Hormonal abnormalities in obesity. Acta Med Scan. 1988;723:153-60.
  19. Bjorntorp P. Hyperandrogenicity in women- a prediabetic condition? J Intern Med. 1993; 234: 579-83.
  20. Leenen R., Kooy K.V., Seidell J.C., Deurenberg P., Koppeschaar H.P.E. Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight loss therapy. J Clin Endocrinol Metab. 1994;78:1551-20.
  21. Pasqualli R., Antenucci D., Casimiri F., Rissanen C. Clinical and hormonal characteristics of obese amenhorric hyperandrogenic women before and after weight loss. J Clin Endocrinol Metab. 1989;68:173-8.
  22. Turcato E., Zamboni M., De Pergola G., Armellini F., Zivelonghi A., Bergamo-Andreis I.A., Giorgino R., Bosello O. Interrelationship between weight loss, body fat distribution and sex hormones in pre and postmenopausal obese women. Int J Obs. 1997;241:363-72.
  23. Bates G.W., Whitworth N.S. Effect of body weight reduction on plasma androgen in obese, infertile women. Fertil Steril. 1988;38:406-9.


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